Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Abstract
A human antibody to interleukin-17A is well tolerated and may be effective in the treatment of psoriasis, rheumatoid arthritis, and noninfectious uveitis.
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IL-17A/F double-deficient mice are highly resistant to EAE development.
“when using genetically deficient IL-17A and IL-17F mice, our own unpublished studies and those of others have shown that IL-17A/F double-deficient mice were highly resistant to the development of EAE”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [116]
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- Authors
- Hueber, W., Patel, D. D., Dryja, T., Wright, A. M., Koroleva, I., Bruin, G., Antoni, C., Draelos, Z., Gold, M. H., the Psoriasis Study Group, Durez, P., Tak, P. P., Gomez-Reino, J. J., the Rheumatoid Arthritis Study Group, Foster, C. S., Kim, R. Y., Samson, C. M., Falk, N. S., Chu, D. S., Callanan, D., Nguyen, Q. D., the Uveitis Study Group, Rose, K., Haider, A., & Di Padova, F.
- Affiliations
- Novartis Institutes for BioMedical Research (CH)
- Novartis (Switzerland) (CH)
- Novartis (United States) (US)
- Dermatology Consulting Services (US)
- Tennessee Clinical Research Center (US)
- UCLouvain (BE)
- Amsterdam UMC Location University of Amsterdam (NL)
- Universidade de Santiago de Compostela (ES)
- Hospital Clínico Universitario/Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
- Retina Consultants of Texas (US)
- New York Eye and Ear Infirmary (US)
- Texas Retina Associates (United States) (US)
- Johns Hopkins University (US)
- Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
- Corresponding author
- Patel, Dhavalkumar D.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-10-06
- Volume
- 2
- Issue
- 52
- Pages
- 52ra72-52ra72
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2112128505
- Cited by
- 860
- References
- 48
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 24 · 2023: 24 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 48 · 2018: 42 · 2017: 75 · 2016: 71 · 2015: 78 · 2014: 96 · 2013: 106 · 2012: 107
- FWCI
- 38.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- IL-17A, neutralizing antibodies, psoriasis, rheumatoid arthritis, non-infectious uveitis, Th17 cells, autoimmunity, inflammatory diseases, PASI, ACR20 response, adverse events, infection
- MeSH terms
- Adolescent, Adult, Aged, Animals, Antibodies, Antibodies, Monoclonal, Arthritis, Rheumatoid, Double-Blind Method, Humans, Middle Aged, Placebos, Psoriasis, Uveitis, Treatment Outcome, Interleukin-17, Young Adult, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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