Block, Karen

NAD(P)H Oxidase Mediates TGF-β1–Induced Activation of Kidney Myofibroblasts

Bondi, C. D., Manickam, N., Lee, D. Y., Block, K., Gorin, Y., Abboud, H. E., & Barnes, J. L. (2010) · Journal of the American Society of Nephrology

TGF-β signaling in diseasesChronic Kidney Disease and Diabetes

Cited by 297

l -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

Shim, E.-H., Livi, C. B., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E.-Y., Ghosh, A. P., Kirkman, R., Velu, S., et al. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 280

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Sudarshan, S., Sourbier, C., Kong, H.-S., Block, K., Romero, V. A. V., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., et al. (2009) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 217

Targeting nadph oxidase with a novel dual nox1/nox4 inhibitor attenuates renal pathology in type 1 diabetes

Gorin, Y., Cavaglieri, R. C., Khazim, K., Lee, D.-Y., Bruno, F., Thakur, S., Fanti, P., Szyndralewiez, C., Barnes, J. L., Block, K., et al. (2015) · American Journal of Physiology-Renal Physiology

Chronic Kidney Disease and DiabetesNitric Oxide and Endothelin Effects

Cited by 183

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation

Menini, S., Iacobini, C., Ricci, C., Oddi, G., Pesce, C., Pugliese, F., Block, K., Abboud, H. E., Giorgio, M., Migliaccio, E., et al. (2007) · Diabetologia

Advanced Glycation End Products researchChronic Kidney Disease and Diabetes

Cited by 64