Poole, Stephen

"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

Stebbings, R., Findlay, L., Edwards, C., Eastwood, D., Bird, C., North, D., Mistry, Y., Dilger, P., Liefooghe, E., Cludts, I., et al. (2007) · The Journal of Immunology

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 316

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 + effector memory T‐cells

Eastwood, D., Findlay, L., Poole, S., Bird, C., Wadhwa, M., Moore, M., Burns, C., Thorpe, R., & Stebbings, R. (2010) · British Journal of Pharmacology

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 300

Interleukin (IL)-6 and IL-1β act synergistically within the brain to induce sickness behavior and fever in rats

Harden, L. M., Plessis, I. D., Poole, S., & Laburn, H. P. (2008) · Brain, Behavior, and Immunity

Thermal Regulation in MedicineTryptophan and brain disorders

Cited by 118

Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS

Lenczowski, M. J. P., Van Dam, A.-M., Poole, S., Larrick, J. W., & Tilders, F. J. H. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 115

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N. (2010) · Molecular Psychiatry

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 88

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

Findlay, L., Eastwood, D., Stebbings, R., Sharp, G., Mistry, Y., Ball, C., Hood, J., Thorpe, R., & Poole, S. (2010) · Journal of Immunological Methods

Monoclonal and Polyclonal Antibodies ResearchImmunotoxicology and immune responses

Cited by 74

After TGN1412: Recent developments in cytokine release assays

Stebbings, R., Eastwood, D., Poole, S., & Thorpe, R. (2013) · Journal of Immunotoxicology

Immunotoxicology and immune responsesAnimal testing and alternatives

Cited by 73

Safety of biologics, lessons learnt from TGN1412

Stebbings, R., Poole, S., & Thorpe, R. (2009) · Current Opinion in Biotechnology

Biosimilars and Bioanalytical MethodsImmunotoxicology and immune responses

Cited by 70

Role of endogenous interleukin‐1 receptor antagonist in regulating fever induced by localised inflammation in the rat

Cartmell, T., Luheshi, G. N., Hopkins, S. J., Rothwell, N. J., & Poole, S. (2001) · The Journal of Physiology

Thermal Regulation in MedicineInflammasome and immune disorders

Cited by 62

Severity of the TGN 1412 trial disaster cytokine storm correlated with IL‐2 release

Eastwood, D., Bird, C., Dilger, P., Hockley, J., Findlay, L., Poole, S., Thorpe, S. J., Wadhwa, M., Thorpe, R., & Stebbings, R. (2013) · British Journal of Clinical Pharmacology

Monoclonal and Polyclonal Antibodies ResearchImmunotoxicology and immune responses

Cited by 58

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture

Findlay, L., Sharp, G., Fox, B., Ball, C., Robinson, C. J., Bird, C., Stebbings, R., Eastwood, D., Wadhwa, M., Poole, S., et al. (2011) · Cytokine

Immunotoxicology and immune responsesMonoclonal and Polyclonal Antibodies Research

Cited by 29