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Cited by 88Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityNeuroinflammation and Neurodegeneration Mechanisms

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

Rummel, C, Inoue, W, Poole, S, Luheshi, G N·2010·Molecular Psychiatry
DOI 10.1038/mp.2009.98
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Abstract

The appetite suppressing hormone leptin has emerged as an important modulator of immune function and is now considered to be a critical link between energy balance and host defense responses to pathogens. These 'adaptive' responses can, in situations of severe and sustained systemic inflammation, lead to adverse effects including brain damage that is partly mediated by neutrophil recruitment into the brain. We examined the contribution of leptin to this process in leptin-deficient (ob/ob), -resistant (db/db) and wild-type (WT) mice injected intraperitoneally with a septic dose of lipopolysaccharide (LPS). This treatment induced a dramatic increase in the number of neutrophils entering the brain of WT mice, an effect that was almost totally abolished in the mutant mice and correlated with a significant reduction in the mRNA levels of interleukin-1beta, intracellular adhesion molecule-1 and neutrophil-specific chemokines. These effects were reversed with leptin replenishment in ob/ob mice leading to recovery of neutrophil recruitment into the brain. Moreover, 48 h food deprivation in WT mice, which decreased circulating leptin levels, attenuated the LPS-induced neutrophil recruitment as did a single injection of an anti-leptin antiserum 4 h before LPS treatment in WT mice. These results provide the first demonstration that leptin has a critical role in leukocyte recruitment to the brain following severe systemic inflammation with possible implications for individuals with altered leptin levels such as during obesity or starvation.

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  • The breakdown of the blood-brain barrier produced by peripheral immune challenge (lipopolysaccharide) permits passage of bone marrow-derived immune cells into the brain, a process enhanced by diet-induced obesity and that favors depressive behaviors.

    “The breakdown of the BBB produced by peripheral immune challenge (LPS) permits passage of bone marrow-derived immune cells into the brain, a process enhanced by DIO [163] and that favors depressive behaviors [164,165].”

    From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [164]

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Authors
Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N.
Affiliations
  • Douglas Mental Health University Institute (CA)
  • National Institute for Biological Standards and Control (GB)
Corresponding author
Luheshi, G N
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2009-09-22
Volume
15
Issue
5
Pages
523-534
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2009.98
OpenAlex
W2078065336
Cited by
88
References
66
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 3
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
leptin, neutrophil recruitment, neuroinflammation, lipopolysaccharide, systemic inflammation, ob/ob mice, db/db mice, IL-1β, intracellular adhesion molecule-1, chemokines, food deprivation, obesity, starvation
MeSH terms
Age Factors, Animals, Brain, Encephalitis, Enzyme-Linked Immunosorbent Assay, Food Deprivation, Gene Expression Regulation, Leukocytes, Lipopolysaccharides, Mice, Transgenic, RNA, Messenger, Signal Transduction, Cytokines, Statistics, Nonparametric, Neutrophil Infiltration, Leptin, Mice

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