Hirsch, Matthew L.

A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype

Ellis, B. L., Hirsch, M. L., Barker, J. C., Connelly, J. P., Steininger, R. J., & Porteus, M. H. (2013) · Virology Journal

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 252

Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application

Monahan, P. E., Lothrop, C. D., Sun, J., Hirsch, M. L., Kafri, T., Kantor, B., Sarkar, R., Tillson, D. M., Elia, J. R., & Samulski, R. J. (2010) · Molecular Therapy

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 125

Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction

Shao, W., Earley, L. F., Chai, Z., Chen, X., Sun, J., He, T., Deng, M., Hirsch, M. L., Ting, J., Samulski, R. J., et al. (2018) · JCI Insight

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 119

Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression

Earley, L. F., Conatser, L. M., Lue, V. M., Dobbins, A. L., Li, C., Hirsch, M. L., & Samulski, R. J. (2020) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 111

Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles

Li, C., Diprimio, N., Bowles, D. E., Hirsch, M. L., Monahan, P. E., Asokan, A., Rabinowitz, J., Agbandje-McKenna, M., & Samulski, R. J. (2012) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 96

Oversized AAV Transductifon Is Mediated via a DNA-PKcs-independent, Rad51C-dependent Repair Pathway

Hirsch, M. L., Li, C., Bellon, I., Yin, C., Chavala, S., Pryadkina, M., Richard, I., & Samulski, R. J. (2013) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 62

A comparison of AAV strategies distinguishes overlapping vectors for efficient systemic delivery of the 6.2 kb Dysferlin coding sequence

Pryadkina, M., Lostal, W., Bourg, N., Charton, K., Roudaut, C., Hirsch, M. L., & Richard, I. (2015) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchNeurogenetic and Muscular Disorders Research

Cited by 53

Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells

Hirsch, M. L., Fagan, B. M., Dumitru, R., Bower, J. J., Yadav, S., Porteus, M. H., Pevny, L. H., & Samulski, R. J. (2011) · PLoS ONE

Virus-based gene therapy researchDNA Repair Mechanisms

Cited by 53

Serotype survey of AAV gene delivery via subconjunctival injection in mice

Song, L., Llanga, T., Conatser, L. M., Zaric, V., Gilger, B. C., & Hirsch, M. L. (2018) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 50

Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens

Nicolson, S. C., Li, C., Hirsch, M. L., Setola, V., & Samulski, R. J. (2016) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 48

Development of patient-specific AAV vectors after neutralizing antibody selection for enhanced muscle gene transfer

Li, C., Wu, S., Albright, B., Hirsch, M., Li, W., Tseng, Y.-S., Agbandje-McKenna, M., McPhee, S., Asokan, A., & Samulski, R. J. (2016) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 48

Adeno-associated virus inverted terminal repeats stimulate gene editing

Hirsch, M. L. (2015) · Gene Therapy

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 32

Inhibition of antigen presentation during AAV gene therapy using virus peptides

Shao, W., Chen, X., Samulski, R. J., Hirsch, M. L., & Li, C. (2018) · Human Molecular Genetics

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 17

Ocular tolerability and immune response to corneal intrastromal AAV-IDUA gene therapy in New Zealand white rabbits

Song, L., Bower, J. J., Llanga, T., Salmon, J. H., Hirsch, M. L., & Gilger, B. C. (2020) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 14