Wang, Y. Alan

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

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Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

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KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer

Liao, W., Overman, M. J., Boutin, A. T., Shang, X., Zhao, D., Dey, P., Li, J., Wang, G., Lan, Z., Li, J., et al. (2019) · Cancer Cell

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Passenger deletions generate therapeutic vulnerabilities in cancer

Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., et al. (2012) · Nature

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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W.-T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., et al. (2017) · Nature

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Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

Ding, Z., Wu, C.-J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., et al. (2012) · Cell

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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

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Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

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Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

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Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., et al. (2015) · Cancer Cell

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SF2312 is a natural phosphonate inhibitor of enolase

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USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

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Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models

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The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment

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USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer

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