Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide
Open accessAbstract
BACKGROUND: A recent study demonstrated evidence of a yellow-orange discoloration of the skin and hair when topical dapsone gel was combined with benzoyl peroxide. This phenomenon had previously been observed by one of us (A.B.F.) when sulfasalazine was combined with benzoyl peroxide. To investigate these interaction phenomena, topical dapsone gel and sulfacetamide sodium lotion were combined with various topical acne treatments, including benzoyl peroxides, clindamycin phosphate, and retinoids. OBSERVATIONS: Products containing benzoyl peroxide produced an orange-brown discoloration when mixed with either sulfacetamide or dapsone. CONCLUSIONS: Knowledge of the chemical reaction between benzoyl peroxide and sulfacetamide and dapsone will help minimize the occurrence of this interaction on our patients' skin.
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Applying benzoyl peroxide together with dapsone or sulfacetamide can cause an orange-brown skin discoloration that can be washed off.
“Concurrent topical application of BP with either dapsone or sulfacetamide causes an orange-brown skin discoloration, which can be washed off; thus BP should be used at a different time of day than topical dapsone.169”
From Guidelines of care for the management of acne vulgaris (2024) · cites this paper as [169]
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Cites
Principles and Practice of Infectious Diseases.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-818_5 · Cited by 12,045 · see citing works
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
Castagnola, E., Viscoli, C., & Mikulska, M. (2015) · Elsevier eBooks · doi:10.1016/c2012-1-00075-6 · Cited by 2,587 · see citing works
Dapsone and sulfones in dermatology: Overview and update
Zhu, Y. I., & Stiller, M. J. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.114733 · Cited by 448 · see citing works
A review of the use of combination therapies for the treatment of acne vulgaris
Leyden, J. J. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/s0190-9622(03)01154-x · Cited by 258 · see citing works
Akhavan, A., & Bershad, S. V. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304070-00004 · Cited by 185 · see citing works
Diagnosis and treatment of acne.
Feldman, S. R., Careccia, R. E., Barham, K. L., & Hancox, J. G. (2004) · PubMed · Cited by 162 · see citing works
Office-Based Physician Services Provided by Dermatologist in the United States in 1990
Fleischer, A. B., Feldman, S. R., & Bradham, D. D. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371739 · Cited by 60 · see citing works
Self-citationPaniker, U., & Levine, N. (2001) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70231-x · Cited by 58 · see citing works
Pharmacokinetics of Dapsone Gel, 5% for the Treatment of Acne Vulgaris
Thiboutot, D. M., Willmer, J., Sharata, H. H., Halder, R. M., & GARRETT, S. J. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746080-00006 · Cited by 45 · see citing works
Pharmacodynamics and pharmacokinetics of topical adapalene
Shroot, B. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70440-2 · Cited by 43 · see citing works
Synergistic Activity of Benzoyl Peroxide and Erythromycin
Burkhart, C. N., Specht, K., & Neckers, D. C. (2000) · Skin Pharmacology and Physiology · doi:10.1159/000029936 · Cited by 43 · see citing works
A comparison of dapsone with 13-cis retinoic acid in the treatment of nodular cystic acne
Prendiville, J., LOGAN, R. A., & Russell‐Jones, R. (1988) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1988.tb00659.x · Cited by 38 · see citing works
THE TREATMENT OF ACNE VULGARIS WITH DAPSONE
Ross, C. M. (1961) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1961.tb14398.x · Cited by 33 · see citing works
Burkhart, C. G., Burkhart, C. N., Burkhart, C. N., et al. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06924.x · Cited by 22 · see citing works
Burkhart, C. G., & Burkhart, C. N. (2007) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2007.03081.x · Cited by 15 · see citing works
Decreased Efficacy of Topical Anesthetic Creams in Presence of Benzoyl Peroxide
Burkhart, C. G., & Burkhart, C. N. (2005) · Dermatologic Surgery · doi:10.2310/6350.2005.31223 · Cited by 9 · see citing works
Antibacterial properties of benzoyl peroxide in aerobic and anaerobic conditions
Burkhart, C. G., & Burkhart, C. N. (2006) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2006.02877.x · Cited by 9 · see citing works
Antibacterial properties of soluble benzoyl peroxide
Burkhart, C. G., & Burkhart, C. N. (2008) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2008.03366.x · Cited by 3 · see citing works
(2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.10.124 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [10]10. Wolf R, Matz H, Orion E, Tuzun B, Tuzun Y. Dapsone. Dermatol Online J. 2002; 8(1):2.
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Guidelines of care for the management of acne vulgaris
Reynolds, R. V., Yeung, H., Cheng, C. E., Cook-Bolden, F., Desai, S. R., Druby, K. M., Freeman, E. E., Keri, J. E., Stein Gold, L. F., Tan, J. K. L., et al. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2023.12.017 · Cited by 518 · see citing works
- Authors
- Dubina, M. I., & Fleischer, A. B.
- Affiliations
- Wake Forest University Health Sciences (US)
- ORCID
- Fleischer, Alan B.
- Venue
- Archives of Dermatology
- Publisher
- American Medical Association (AMA)
- Published
- 2009-09-01
- Volume
- 145
- Issue
- 9
- Pages
- 1027-9
- ISSN
- 0003-987X (ISSN-L)
- OpenAlex
- W1994290584
- Semantic Scholar
- 53e6a7d4fc35755ab070bafa08c03b13914e3cec
- Cited by
- 16
- References
- 19
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2020: 3 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 3
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- benzoyl peroxide, drug interactions, skin discoloration, acne treatment, clindamycin phosphate, retinoids, sulfasalazine
- MeSH terms
- Acne Vulgaris, Administration, Topical, Anti-Infective Agents, Local, Benzoyl Peroxide, Dapsone, Dermatologic Agents, Drug Interactions, Drug Therapy, Combination, Humans, Skin, Sulfacetamide
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