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Resting Metabolic Activity in the Cingulate Cortex and Vulnerability to Posttraumatic Stress Disorder
Open accessAbstract
CONTEXT: Recent neuroimaging research has revealed functional abnormalities in the anterior cingulate cortex, amygdala, and hippocampus in individuals with posttraumatic stress disorder (PTSD). OBJECTIVE: To determine whether resting functional abnormalities found in PTSD are acquired characteristics or familial risk factors. DESIGN: Cross-sectional design including identical twins discordant for trauma exposure. SETTING: Academic medical center. PARTICIPANTS: Combat-exposed veterans with PTSD (n = 14) and their identical co-twins not exposed to combat (n = 14) as well as combat-exposed veterans without PTSD (n = 19) and their identical co-twins not exposed to combat (n = 19). MAIN OUTCOME MEASURES: We used positron emission tomography and fluorodeoxyglucose 18 to examine resting regional cerebral metabolic rate for glucose (rCMRglu). RESULTS: Veterans with PTSD and their co-twins had significantly higher resting rCMRglu in the dorsal anterior cingulate cortex/midcingulate cortex (dACC/MCC) compared with veterans without PTSD and their co-twins. Resting rCMRglu in the dACC/MCC in unexposed co-twins was positively correlated with combat exposure severity, PTSD symptom severity, and alcohol use in their exposed twins. CONCLUSIONS: Enhanced resting metabolic activity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure to psychological trauma.
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“A study authors Shin et al. conducted among veterans with PTSD and their twins showed significantly higher resting cerebral metabolic rate for glucose (rCMRglu) in dorsal anterior cingulate/mid cingulate cortex (dACC/MCC).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Shin et al., 2009
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“Increased dACC activation may constitute a family risk factor for PTSD (Shin et al., 2009).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Shin et al., 2009
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Self-citation
Metadata
- Authors
- Shin, L. M., Lasko, N. B., Macklin, M. L., Karpf, R. D., Milad, M. R., Orr, S. P., Goetz, J. M., Fischman, A. J., Rauch, S. L., & Pitman, R. K.
- Affiliations
- Tufts University (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2009-10-01
- Volume
- 66
- Issue
- 10
- Pages
- 1099
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC3752096
- OpenAlex
- W2154032489
- Cited by
- 151
- References
- 97
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 17 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 12
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01-MH54636, R01MH054636)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, anterior cingulate cortex, combat veterans, monozygotic twins, family risk factors, combat exposure, alcohol consumption, PTSD symptom severity
- MeSH terms
- Amygdala, Combat Disorders, Disease Susceptibility, Diseases in Twins, Glucose, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Life Change Events, Male, Middle Aged, Regional Blood Flow, Rest, Stress Disorders, Post-Traumatic, Veterans, Fluorodeoxyglucose F18, Positron-Emission Tomography
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