Cited by 151Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchChild Abuse and Trauma

The DOI matches its Crossref record; 96 of the 97 references it cites were found in a registry or an index.

Resting Metabolic Activity in the Cingulate Cortex and Vulnerability to Posttraumatic Stress Disorder

Open access

Shin, Lisa M., Lasko, Natasha B., Macklin, Michael L., Karpf, Rachel D., Milad, Mohammed R., Orr, Scott P., Goetz, Jared M., Fischman, Alan J., Rauch, Scott L., Pitman, Roger K.·2009·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2009.138PMC PMC3752096

Open this paper in CoChat — free account

Abstract

CONTEXT: Recent neuroimaging research has revealed functional abnormalities in the anterior cingulate cortex, amygdala, and hippocampus in individuals with posttraumatic stress disorder (PTSD). OBJECTIVE: To determine whether resting functional abnormalities found in PTSD are acquired characteristics or familial risk factors. DESIGN: Cross-sectional design including identical twins discordant for trauma exposure. SETTING: Academic medical center. PARTICIPANTS: Combat-exposed veterans with PTSD (n = 14) and their identical co-twins not exposed to combat (n = 14) as well as combat-exposed veterans without PTSD (n = 19) and their identical co-twins not exposed to combat (n = 19). MAIN OUTCOME MEASURES: We used positron emission tomography and fluorodeoxyglucose 18 to examine resting regional cerebral metabolic rate for glucose (rCMRglu). RESULTS: Veterans with PTSD and their co-twins had significantly higher resting rCMRglu in the dorsal anterior cingulate cortex/midcingulate cortex (dACC/MCC) compared with veterans without PTSD and their co-twins. Resting rCMRglu in the dACC/MCC in unexposed co-twins was positively correlated with combat exposure severity, PTSD symptom severity, and alcohol use in their exposed twins. CONCLUSIONS: Enhanced resting metabolic activity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure to psychological trauma.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/archgenpsychiatry.2009.138

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
SAS System for Mixed Models
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,345
Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
The Michigan Alcoholism Screening Test: The Quest for a New Diagnostic Instrument
Selzer, M. L. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.127.12.1653 · Cited by 3,431
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882

Show all 97 references

Sorted by citations

The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083
Self-citation
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Self-citation
A pathophysiological framework of hippocampal dysfunction in ageing and disease
Small, S. A., Schobel, S., Buxton, R. B., Witter, M. P., & Barnes, C. A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3085 · Cited by 955
Comorbidity between post-traumatic stress disorder and major depressive disorder: Alternative explanations and treatment considerations
Flory, J. D., & Yehuda, R. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.2/jflory · Cited by 629
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546
Self-citation
Midcingulate cortex: Structure, connections, homologies, functions and diseases
Vogt, B. A. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.01.010 · Cited by 471
From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders
VanElzakker, M. B., Kathryn Dahlgren, M., Caroline Davis, F., Dubois, S., & Shin, L. M. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.014 · Cited by 482
Self-citation
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452
Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 467
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 447
Neural Dysregulation in Posttraumatic Stress Disorder: Evidence for Disrupted Equilibrium Between Salience and Default Mode Brain Networks
Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318273bf33 · Cited by 412
The Study of Fear Extinction: Implications for Anxiety Disorders
Graham, B. M., & Milad, M. R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040557 · Cited by 387
Self-citation
Anxiety Dissociates Dorsal and Ventral Medial Prefrontal Cortex Functional Connectivity with the Amygdala at Rest
Kim, M. J., Gee, D. G., Loucks, R. A., Davis, F. C., & Whalen, P. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq237 · Cited by 388
Functional neuroimaging studies of post-traumatic stress disorder
Hughes, K. C., & Shin, L. M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.198 · Cited by 290
Self-citation
A causal model of post-traumatic stress disorder: disentangling predisposed from acquired neural abnormalities
Admon, R., Milad, M. R., & Hendler, T. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.05.005 · Cited by 284
Self-citation
Etiology of depression comorbidity in combat-related PTSD: a review of the literature
Stander, V. A., Thomsen, C. J., & Highfill-McRoy, R. M. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.12.002 · Cited by 271
Hippocampal dysfunction effects on context memory: Possible etiology for posttraumatic stress disorder
Acheson, D. T., Gresack, J. E., & Risbrough, V. B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.029 · Cited by 221
The effects of psychotherapy on brain function: A systematic and critical review
Barsaglini, A., Sartori, G., Benetti, S., Pettersson‐Yeo, W., & Mechelli, A. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.006 · Cited by 225
Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Scott, J. C., Averill, L. A., Schweinsburg, B., Alexander-Bloch, A., Martini, B., Southwick, S. M., Krystal, J. H., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.005 · Cited by 188
Neuroimaging resilience to stress: a review
van der Werff, S. J. A., van den Berg, S. M., Pannekoek, J. N., Elzinga, B. M., & van der Wee, N. J. A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00039 · Cited by 188
Perceived threat predicts the neural sequelae of combat stress
van Wingen, G. A., Geuze, E., Vermetten, E., & Fernández, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.132 · Cited by 173
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry
Harnett, N. G., Goodman, A. M., & Knight, D. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113331 · Cited by 201
Exaggerated Activation of Dorsal Anterior Cingulate Cortex During Cognitive Interference: A Monozygotic Twin Study of Posttraumatic Stress Disorder
Shin, L. M., Bush, G., Milad, M. R., Lasko, N. B., Brohawn, K. H., Hughes, K. C., Macklin, M. L., Gold, A. L., Karpf, R. D., Orr, S. P., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.09121812 · Cited by 170
Self-citation
AMYGDALA RESPONSE TO NEGATIVE STIMULI PREDICTS PTSD SYMPTOM ONSET FOLLOWING A TERRORIST ATTACK
McLaughlin, K. A., Busso, D. S., Duys, A., Green, J. G., Alves, S., Way, M., & Sheridan, M. A. (2014) · Depression and Anxiety · doi:10.1002/da.22284 · Cited by 152
Dynamic functional connectomics signatures for characterization and differentiation of PTSD patients
Li, X., Zhu, D., Jiang, X., Jin, C., Zhang, X., Guo, L., Zhang, J., Hu, X. P., Li, L., & Liu, T. (2013) · Human Brain Mapping · doi:10.1002/hbm.22290 · Cited by 139
Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis
Wang, T., Liu, J., Zhang, J., Zhan, W., Li, L., Wu, M. C., Huang, H., Zhu, H., Kemp, G. J., & Gong, Q. (2016) · Scientific Reports · doi:10.1038/srep27131 · Cited by 137
The emotional Stroop task and posttraumatic stress disorder: A meta-analysis
Cisler, J. M., Wolitzky-Taylor, K. B., Adams, T. G., Babson, K. A., Badour, C. L., & Willems, J. L. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.03.007 · Cited by 151
Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies
Déjean, C., Courtin, J., Rozeske, R. R., Bonnet, M. C., Dousset, V., Michelet, T., & Herry, C. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.017 · Cited by 130
Posttraumatic stress disorder: a theoretical model of the hyperarousal subtype
Weston, C. S. E. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00037 · Cited by 114
Sex differences in extinction recall in posttraumatic stress disorder: A pilot fMRI study
Shvil, E., Sullivan, G. M., Schafer, S., Markowitz, J. C., Campeas, M., Wager, T. D., Milad, M. R., & Neria, Y. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.003 · Cited by 113
Self-citation
Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies
Roeckner, A. R., Oliver, K. I., Lebois, L. A. M., van Rooij, S. J. H., & Stevens, J. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01633-y · Cited by 103
Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies
Suarez‐Jimenez, B., Albajes‐Eizagirre, A., Lazarov, A., Zhu, X., Harrison, B. J., Raduà, J., Neria, Y., & Fullana, M. A. (2019) · Psychological Medicine · doi:10.1017/s0033291719001387 · Cited by 125
Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex
Henigsberg, N., Kalember, P., Petrović, Z. K., & Šečić, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.003 · Cited by 105
Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip
Dauth, S., Maoz, B. M., Sheehy, S. P., Hemphill, M. A., Murty, T., Macedonia, M. K., Greer, A. M., Budnik, B., & Parker, K. K. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00575.2016 · Cited by 112
INSULA AND ANTERIOR CINGULATE GABA LEVELS IN POSTTRAUMATIC STRESS DISORDER: PRELIMINARY FINDINGS USING MAGNETIC RESONANCE SPECTROSCOPY: Research Article: Insula GABA in PTSD
Rosso, I. M., Weiner, M. R., Crowley, D. J., Silveri, M. M., Rauch, S. L., & Jensen, J. E. (2014) · Depression and Anxiety · doi:10.1002/da.22155 · Cited by 101
Self-citation
Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?
Shin, L. M., & Handwerger, K. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20442 · Cited by 102
Self-citation
Persistent prelimbic cortex activity contributes to enhanced learned fear expression in femalesPreprint
Fenton, G. E., Pollard, A. K., Halliday, D. M., Mason, R., Bredy, T. W., & Stevenson, C. W. (2014) · Learning & Memory · doi:10.1101/lm.033514.113 · Cited by 101
Post-traumatic stress disorder: a right temporal lobe syndrome?
Engdahl, B., Leuthold, A. C., Tan, H.-R. M., Lewis, S. M., Winskowski, A. M., Dikel, T. N., & Georgopoulos, A. P. (2010) · Journal of Neural Engineering · doi:10.1088/1741-2560/7/6/066005 · Cited by 97
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.9.3.foc311 · Cited by 105
Self-citation
Resting Amygdala and Medial Prefrontal Metabolism Predicts Functional Activation of the Fear Extinction Circuit
Linnman, C., Zeidan, M. A., Furtak, S. C., Pitman, R. K., Quirk, G. J., & Milad, M. R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10121780 · Cited by 107
Self-citation
Biological Markers in Anxiety Disorders
Łoś, K., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081744 · Cited by 105
Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD
Wrocklage, K. M., Averill, L. A., Scott, J. C., Averill, C. L., Schweinsburg, B. C., Trejo, M., Roy, A. M., Weisser, V. D., Kelly, C., Martini, B. L., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.02.010 · Cited by 97
Real-time fMRI neurofeedback with War Veterans with chronic PTSD: a feasibility study
Gerin, M. I., Fichtenholtz, H., Roy, A., Walsh, C. J., Krystal, J. H., Southwick, S., & Hampson, M. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00111 · Cited by 84
Sustained anxiety increases amygdala–dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults
Vytal, K. E., Overstreet, C. M., Charney, D. R., Robinson, O. J., & Grillon, C. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130145 · Cited by 82
Association of Resting Metabolism in the Fear Neural Network With Extinction Recall Activations and Clinical Measures in Trauma-Exposed Individuals
Marin, M.-F., Song, H., VanElzakker, M. B., Staples-Bradley, L. K., Linnman, C., Pace-Schott, E. F., Lasko, N. B., Shin, L. M., & Milad, M. R. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14111460 · Cited by 74
Self-citation
Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson’s Disease
Hu, X., Song, X., Erfeng, L., Liu, J., Yuan, Y., Liu, W., & Liu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131133 · Cited by 73
Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex
Treadway, M. T., Buckholtz, J. W., & Zald, D. H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00180 · Cited by 72
Childhood and adult trauma both correlate with dorsal anterior cingulate activation to threat in combat veterans
Herringa, R. J., Phillips, M. L., Fournier, J. C. J., Kronhaus, D. M., & Germain, A. (2012) · Psychological Medicine · doi:10.1017/s0033291712002310 · Cited by 68
Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability
Bowirrat, A., Chen, T. J. H., Blum, K., Madigan, M. A., Bailey, J. A., Chen, A. L. C., Downs, B. W., Braverman, E. R., Shahien, R., Waite, R. L., et al. (2010) · Current Neuropharmacology · doi:10.2174/157015910793358123 · Cited by 70
Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
Fenton, G. E., Halliday, D. M., Mason, R., Bredy, T. W., & Stevenson, C. W. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.019 · Cited by 68
Neuropsychological and neuroimaging findings in traumatic brain injury and post-traumatic stress disorder
Brenner, L. A. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.3/lbrenner · Cited by 66
Psychological and Brain Connectivity Changes Following Trauma-Focused CBT and EMDR Treatment in Single-Episode PTSD Patients
Santarnecchi, E., Bossini, L., Vatti, G., Fagiolini, A. M., Porta, P. L., Lorenzo, G. D., Siracusano, A., Rossi, S., & Rossi, A. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00129 · Cited by 71
The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD
Neumeister, A. (2013) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.s4-006 · Cited by 58
Tempering aversive/traumatic memories with cannabinoids: A review of evidence from animal and human studies
Lisboa, S. F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., & Guimaraes, F. S. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5127-x · Cited by 54
Altered brain structural connectivity in post-traumatic stress disorder: A diffusion tensor imaging tractography study
Long, Z., Duan, X., Xie, B., Du, H., Li, R., Xu, Q., Wei, L., Zhang, S., Wu, Y., Gao, Q. C., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.03.004 · Cited by 55
Diminished medial prefrontal cortex activation during the recollection of stressful events is an acquired characteristic of PTSD
Dahlgren, M. K., Laifer, L. M., VanElzakker, M. B., Offringa, R., Hughes, K. C., Staples-Bradley, L. K., Dubois, S. J., Lasko, N. B., Hinojosa, C. A., Orr, S. P., et al. (2018) · Psychological Medicine · doi:10.1017/s003329171700263x · Cited by 55
Self-citation
Posttraumatic stress disorder is associated with limited executive resources in a working memory task
Honzel, N., Justus, T. C., & Diane Swick, A. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0219-x · Cited by 51
Pituitary adenylate cyclase-activating polypeptide (PACAP) signaling in the prefrontal cortex modulates cued fear learning, but not spatial working memory, in female rats
Kirry, A. J., Herbst, M. R., Poirier, S. E., Maskeri, M. M., Rothwell, A. C., Twining, R. C., & Gilmartin, M. R. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.010 · Cited by 46
A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress
Adamec, R., Toth, M., Haller, J., Halasz, J., & Blundell, J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.016 · Cited by 37
Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder
Zhu, H., Zhang, J., Wang, Z., Qiu, C., Wu, R., Meng, Y., Cui, H., Huang, X., Li, T., Gong, Q., et al. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.06.009 · Cited by 39
Altered cortical and subcortical local coherence in PTSD: evidence from resting-state fMRI
Zhong, Y., Zhang, R., Li, K., Qi, R., Zhang, Z., Huang, Q., & Lu, G. (2014) · Acta Radiologica · doi:10.1177/0284185114537927 · Cited by 39
Corticostriatal circuitry in regulating diseases characterized by intrusive thinking
Kalivas, B. C., & Kalivas, P. W. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/pkalivas · Cited by 43
Tracking resting state connectivity dynamics in veterans with PTSD
Yuan, H., Phillips, R., Wong, C. K., Zotev, V. S., Misaki, M., Wurfel, B. E., Krüeger, F., Feldner, M. T., & Bodurka, J. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.04.014 · Cited by 39
Increased functional segregation of brain network associated with symptomatology and sustained attention in chronic post-traumatic stress disorder
Zhu, H., Li, Y., Yuan, M., Ren, Z., Yuan, C., Meng, Y., Wang, J., Deng, W., Qiu, C., Huang, X., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.01.012 · Cited by 37
Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable
Seligowski, A. V., Harnett, N. G., Merker, J. B., & Ressler, K. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.006 · Cited by 39
Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study
Schmidt, U., Willmund, G., Holsboer, F., Wotjak, C. T., Gallinat, J., Kowalski, J. T., & Zimmermann, P. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.020 · Cited by 37
Imaging in posttraumatic stress disorder
Robinson, B. L., & Shergill, S. S. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283413519 · Cited by 36
Glucocorticoid receptor number predicts increase in amygdala activity after severe stress
Geuze, E., van Wingen, G. A., van Zuiden, M., Rademaker, A. R., Vermetten, E. H. G. J. M., Kavelaars, A., Fernández, G., & Heijnen, C. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.017 · Cited by 35
Inter-hemispheric functional and anatomical connectivity abnormalities in traffic accident-induced PTSD: a study combining fMRI and DTI
Sun, Y., Hu, H., Wang, Y., Ding, W., Chen, X., Wan, J., Zhou, Y., Wang, Z., & Xu, J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.021 · Cited by 34
Regional cerebral glucose metabolism differentiates danger- and non-danger-based traumas in post-traumatic stress disorder
Ramage, A. E., Litz, B. T., Resick, P. A., Woolsey, M. D., Dondanville, K. A., Young‐McCaughan, S., Borah, A. M., Borah, E. V., Peterson, A. L., & Fox, P. T. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv102 · Cited by 39
Stress, trauma and PTSD: translational insights into the core synaptic circuitry and its modulation
Bennett, M. R., Hatton, S. N., & Lagopoulos, J. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1056-1 · Cited by 37
Linked networks for learning and expressing location-specific threat
Suarez‐Jimenez, B., Bisby, J. A., Horner, A. J., King, J. A., Pine, D. S., & Burgess, N. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714691115 · Cited by 31
Resting cerebral metabolism correlates with skin conductance and functional brain activation during fear conditioning
Linnman, C., Zeidan, M. A., Pitman, R. K., & Milad, M. R. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.12.012 · Cited by 33
Self-citation
Reprint of: Resting cerebral metabolism correlates with skin conductance and functional brain activation during fear conditioning
Linnman, C., Zeidan, M. A., Pitman, R. K., & Milad, M. R. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.002 · Cited by 29
Self-citation
Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault
Kim, S.-Y., Chung, Y. K., Kim, B. S., Lee, S. J., Yoon, J., & An, Y. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.08.007 · Cited by 28
PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons
Wen, L., Xiao, B., Shi, Y., & Han, F. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1371-5 · Cited by 28
Molecular Neuroimaging in Posttraumatic Stress Disorder
Im, J. J., Namgung, E., Choi, Y., Kim, J., Rhie, S. J., & Yoon, S. J. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.6.277 · Cited by 29
Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model
Tanaka, M., Li, H., Zhang, X., Singh, J., Dalgard, C. L., Wilkerson, M. D., & Zhang, Y. (2019) · Molecular Brain · doi:10.1186/s13041-019-0449-0 · Cited by 24
Cingulate subregions in posttraumatic stress disorder, chronic stress, and treatment
Hinojosa, C. A., Kaur, N., VanElzakker, M. B., & Shin, L. M. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00020-0 · Cited by 26
Self-citation
Systems biology approach to understanding post-traumatic stress disorder
Thakur, G., Daigle, B. J., Dean, K. R., Zhang, Y., Rodriguez-Fernández, M., Hammamieh, R., Yang, R., Jett, M., Palma, J., Petzold, L. R., et al. (2015) · Molecular BioSystems · doi:10.1039/c4mb00404c · Cited by 25
Psychological stress is associated with arterial inflammation in people living with treated HIV infection
Chow, F. C., Mundada, N. S., Abohashem, S., Joie, R. L., Iaccarino, L., Arechiga, V. M., Swaminathan, S., Rabinovici, G. D., Epel, E. S., Tawakol, A. A., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.019 · Cited by 21
Posttraumatic Stress Disorder: Neurocircuitry and Implications for Potential Deep Brain Stimulation
Taghva, A. S., Oluigbo, C. O., Corrigan, J. D., & Rezai, A. R. (2013) · Stereotactic and Functional Neurosurgery · doi:10.1159/000343148 · Cited by 20
Diagnosis and Management of Sleep Disorders in Posttraumatic Stress Disorder
Mohsenin, S., & Mohsenin, V. (2014) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.14r01663 · Cited by 19
Systematic review of in-vivo neuro magnetic resonance spectroscopy for the assessment of posttraumatic stress disorder
Quadrelli, S., Mountford, C. E., & Ramadan, S. A. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.07.001 · Cited by 19
Revisiting the Role of the Amygdala in Posttraumatic Stress Disorder
Forster, G. L., Simons, R. M., & Baugh, L. A. (2017) · InTech eBooks · doi:10.5772/67585 · Cited by 22
Neuroimaging of PTSD
Campanella, C., & Bremner, J. D. (2016) · Wiley eBooks · doi:10.1002/9781118356142.ch12 · Cited by 17
Projections from anteromedial thalamus nucleus to the midcingulate cortex mediate pain and anxiety-like behaviors in mice
Hong, J., Li, J., Wu, F.-L., Bao, S.-Y., Sun, H.-X., Zhu, K.-H., Cai, Z.-P., Li, F., & Li, Y.-Q. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105640 · Cited by 16
High Thought Control Ability, High Resilience: The Effect of Temporal Cortex and Insula Connectivity
Shi, L., Ren, Z., & Qiu, J. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.07.034 · Cited by 16
The Neurocircuitry of Fear and PTSD
VanElzakker, M. B., Staples-Bradley, L. K., & Shin, L. M. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_10 · Cited by 19
Self-citation
Sportaktivität, Stress und das Gehirn
Ludyga, S. (2017) · Springer eBooks · doi:10.1007/978-3-662-49322-9_11 · Cited by 14
Exaggerated amygdala activation to ambiguous facial expressions is a familial vulnerability factor for posttraumatic stress disorder
Hinojosa, C. A., VanElzakker, M. B., Hughes, K. C., Offringa, R., Sangermano, L., Spaulding, I. G., Staples-Bradley, L. K., Whitman, E. T., Lasko, N. B., Rauch, S. L., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.049 · Cited by 13
Self-citation
Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly
Calati, R., Maller, J. J., Meslin, C., López‐Castromán, J., Ritchie, K. A., Courtet, P., & Artéro, S. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1258490 · Cited by 15
Neurobehavioral assessment in forensic practice
Woods, G. W., Freedman, D., & Greenspan, S. (2012) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2012.09.014 · Cited by 14
Posttraumatic Stress and the Comprehension of Everyday Activity
Eisenberg, M. L., Sargent, J. Q., & Zacks, J. M. (2016) · Collabra · doi:10.1525/collabra.43 · Cited by 14
Acute and Post-Traumatic Stress Disorders: A biased nervous system
Allène, C., Kalalou, K., Durand, F., Thomas, F., & Januel, D. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.05.010 · Cited by 16
Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets
Rahman, S. S., Mulvihill, K. G., Wood, C. M., Quah, S. K. L., Horst, N. K., Clarke, H. F., Cockcroft, G. J., Santangelo, A. M., & Roberts, A. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab121 · Cited by 11
Trauma and the default mode network: review and exploratory study
Chan, A., Harvey, P. D., Hernandez-Cardenache, R., Alperin, N. J., Lee, S. H., Hunt, C., Petersen, N., Northoff, G., Robertson, N., Ouyang, J., et al. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1499408 · Cited by 13
Functional magnetic resonance imaging of the brain: A quick review
Vaghela, V., Kesavadas, C., & Thomas, B. (2010) · Neurology India · doi:10.4103/0028-3886.73735 · Cited by 12
Mapping Cingulate Subregions
Vogt, B. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00230-x · Cited by 11

Authors: Shin, L. M., Lasko, N. B., Macklin, M. L., Karpf, R. D., Milad, M. R., Orr, S. P., Goetz, J. M., Fischman, A. J., Rauch, S. L., & Pitman, R. K.
Affiliations: Tufts University (US)
ORCID: Shin, Lisa M.
Milad, Mohammed R.
Orr, Scott P.
Goetz, Jared M.
Rauch, Scott L.
Pitman, Roger K.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2009-10-01
Volume: 66
Issue: 10
Pages: 1099
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2009.138
PMC: PMC3752096
OpenAlex: W2154032489
Cited by: 151
References: 97
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 17 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 12
FWCI: 12.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01-MH54636, R01MH054636)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: post-traumatic stress disorder, anterior cingulate cortex, combat veterans, monozygotic twins, family risk factors, combat exposure, alcohol consumption, PTSD symptom severity
MeSH terms: Amygdala, Combat Disorders, Disease Susceptibility, Diseases in Twins, Glucose, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Life Change Events, Male, Middle Aged, Regional Blood Flow, Rest, Stress Disorders, Post-Traumatic, Veterans, Fluorodeoxyglucose F18, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Resting Metabolic Activity in the Cingulate Cortex and Vulnerability to Posttraumatic Stress Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks