The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Systematic Review of Early Cardiometabolic Outcomes of the First Treated Episode of Psychosis
Abstract
CONTEXT: The increased mortality associated with schizophrenia is largely due to cardiovascular disease. Treatment with antipsychotics is associated with weight gain and changes in other cardiovascular risk factors. Early identification of modifiable cardiovascular risk factors is a clinical imperative but prospective longitudinal studies of the early cardiometabolic adverse effects of antipsychotic drug treatment other than weight gain have not been previously reviewed. OBJECTIVES: To assess the methods and reporting of cardiometabolic outcome studies of the first treated episode of psychosis, review key findings, and suggest directions for future research. DATA SOURCES: PsycINFO, MEDLINE, and Scopus from January 1990 to June 2010. STUDY SELECTION: Subjects were experiencing their first treated episode of psychosis. Subjects were antipsychotic naive or had been exposed to antipsychotics for a short known period at the beginning of the study. Cardiometabolic indices were assessed. Studies used a longitudinal design. DATA EXTRACTION: Sixty-four articles were identified describing 53 independent studies; 25 studies met inclusion criteria and were retained for detailed review. DATA SYNTHESIS: Consolidated Standards of Reporting Trials and Strengthening the Reporting of Observational Studies in Epidemiology checklists were used to assess the methods and reporting of studies. A qualitative review of findings was conducted. CONCLUSIONS: Two key hypotheses were identified based on this review: (1) in general, there is no difference in cardiovascular risk assessed by weight or metabolic indices between individuals with an untreated first episode of psychosis and healthy controls and (2) cardiovascular risk increases after first exposure to any antipsychotic drug. A rank order of drugs can be derived but there is no evidence of significant class differences. Recommended directions for future research include assessing the effect on cardiometabolic outcomes of medication adherence and dosage effects, determining the therapeutic window for antipsychotic use in adults and youth, and testing for moderation of outcomes by demographic factors, including sex and age, and clinical and genetic factors.
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The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
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Physical Health Monitoring of Patients With Schizophrenia
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Liu, N. H., Daumit, G. L., Dua, T., Aquila, R., Charlson, F., Cuijpers, P., Druss, B., Dudek, K., Freeman, M., Fujii, C., et al. (2017) · World Psychiatry · doi:10.1002/wps.20384 · Cited by 865
A systematic review and meta-analysis of exercise interventions in schizophrenia patients
Firth, J., Cotter, J., Elliott, R., French, P., & Yung, A. R. (2015) · Psychological Medicine · doi:10.1017/s0033291714003110 · Cited by 600
Barnes, T. R., Drake, R., Paton, C., Cooper, S. J., Deakin, B., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 606
Alvares, G. A., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140217 · Cited by 503
Metadata
- Authors
- Foley, D. L., & Morley, K. I.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2011-06-06
- Volume
- 68
- Issue
- 6
- Pages
- 609
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2141071939
- Cited by
- 287
- References
- 68
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
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