Cited by 202Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchHealthcare Systems and Public Health

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Major Factors in the Development of Diabetes Mellitus in 10,000 Men

Medalie, Jack H.·1975·Archives of Internal Medicine

DOI 10.1001/archinte.135.6.811

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Abstract

The average annual incidence of diabetes among 8,688 adult men followed up for five years was 8.0/1,000 with Asian, African and Israeli-born having higher rates than European-born. Multivariate analysis of the findings suggested the following: the most significant variables associated with the development of diabetes are overweight and peripheral vascular disease; the high incidence of diabetes in immigrants from Asia and Africa might be an example of Neel's "thrifty genotype" or failure of adaptation to relatively rapid environmental changes; serum cholesterol level, blood pressure, uric acid level, and education were important also; and the probability of developing diabetes within five years rises from 17/1,000 (when the major variables are low or absent) to 450/1,000 (when they are high and present). This has important clinical implications.

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Authors: Medalie, J. H.
Corresponding author: Medalie, Jack H.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1975-06-01
Volume: 135
Issue: 6
Pages: 811
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.135.6.811
OpenAlex: W1999024460
Cited by: 202
References: 22
Citations by year: 2026: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 5
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Keywords: diabetes mellitus, incidence, risk factors, overweight, peripheral vascular disease, immigrant health, Asian immigrants, African immigrants, thrifty genotype, serum cholesterol, blood pressure, uric acid, educational attainment, men
MeSH terms: Adaptation, Physiological, Adult, Africa, Northern, Age Factors, Asia, Blood Glucose, Blood Pressure, Body Height, Body Weight, Cholesterol, Diabetes Mellitus, Educational Status, Ethnicity, Europe, Genotype, Glucose Tolerance Test, Humans, Intermittent Claudication, Israel, Male, Middle Aged, Prospective Studies, Risk, Uric Acid, Vascular Diseases

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Major Factors in the Development of Diabetes Mellitus in 10,000 Men

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