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Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures

Christian Brun‐Buisson·1987·Archives of Internal Medicine

Abstract

The results of a simplified quantitative broth dilution quantitative tip culture (QTC) of 331 central venous catheters were compared with clinical data prospectively recorded in critically III patients to diagnose bacteremic or nonbacteremic catheter-related sepsis (CRS) (36 catheters), as opposed to contamination (42 catheters) or simple colonization from a distant septic focus (seven catheters). Thirty-five of 36 catheters associated with CRS yielded 10(3) colony-forming units per milliliter (CFU/mL) or more, and 3.8 X 10(2) Candida organisms grew from one. In contrast, 5 X 10(2) CFU/mL or less grew from 37 of 42 contaminated catheters. A QTC of 10(3) CFU/mL or more was 97.5% sensitive and 88% specific for the diagnosis of CRS. The QTC appeared especially useful for the diagnosis of CRS secondary to blood-borne seeding of catheters, or associated with coagulase-negative staphylococci.

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Metadata

Authors
Brun‐Buisson, C.
Venue
Archives of Internal Medicine
Publisher
American Medical Association
Published
1987-05-01
Volume
147
Issue
5
Pages
873-877
ISSN
0003-9926 (ISSN-L)
OpenAlex
W4256421868
Cited by
519
References
0
FWCI
22.26
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. https://app.cochat.ai/papers/10.1001/archinte.147.5.873
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Brun‐Buisson, C. (1987). Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Archives of Internal Medicine. https://doi.org/10.1001/archinte.147.5.873

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