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Cited by 1,012

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

The Lipid Treatment Assessment Project (L-TAP): A Multicenter Survey to Evaluate the Percentages of Dyslipidemic Patients Receiving Lipid-Lowering Therapy and Achieving Low-Density Lipoprotein Cholesterol Goals

Pearson, Thomas A., Laurora, Irene, Chu, Henry, Kafonek, Stephanie·2000·Archives of Internal Medicine
DOI 10.1001/archinte.160.4.459
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Abstract

OBJECTIVE: To determine the percentage of patients in the multicenter Lipid Treatment Assessment Project receiving lipid-lowering therapy who are achieving low-density lipoprotein cholesterol (LDL-C) goals as defined by National Cholesterol Education Program (NCEP) guidelines. METHODS: Adult patients with dyslipidemia, who had been receiving the same lipid-lowering therapy for at least 3 months, were assessed at investigation sites. Lipid levels were determined once in each patient at the time of enrollment. The primary end point was the success rate, defined as the proportion of patients who achieved their LDL-C target level as specified by NCEP guidelines. RESULTS: A total of 4888 patients from 5 regions of the United States were studied. Of these, 23% had fewer than 2 risk factors for coronary heart disease (CHD) and no evidence of CHD (low-risk group), 47% had 2 or more risk factors and no evidence of CHD (high-risk group), and 30% had established CHD. Overall, only 38% of patients achieved NCEP-specified LDL-C target levels; success rates were 68% among low-risk patients, 37% among high-risk patents, and 18% among patients with CHD. Drug therapy was significantly (P< or =.001) more effective than nondrug therapy in all patient risk groups. However, many patients treated with lipid-lowering drugs did not achieve LDL-C target levels. CONCLUSIONS: Large proportions of dyslipidemic patients receiving lipid-lowering therapy are not achieving NCEP LDL-C target levels. These findings indicate that more aggressive treatment of dyslipidemia is needed to attain goals established by NCEP guidelines.

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Metadata

Authors
Pearson, T. A., Laurora, I., Chu, H., & Kafonek, S.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2000-02-28
Volume
160
Issue
4
Pages
459
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.160.4.459
OpenAlex
W2140072878
Cited by
1,012
References
21
FWCI
87.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Lipid Treatment Assessment Project (L-TAP): A Multicenter Survey to Evaluate the Percentages of Dyslipidemic Patients Receiving Lipid-Lowering Therapy and Achieving Low-Density Lipoprotein Cholesterol Goals. https://app.cochat.ai/papers/10.1001/archinte.160.4.459
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Pearson, T. A., Laurora, I., Chu, H., & Kafonek, S. (2000). The Lipid Treatment Assessment Project (L-TAP): A Multicenter Survey to Evaluate the Percentages of Dyslipidemic Patients Receiving Lipid-Lowering Therapy and Achieving Low-Density Lipoprotein Cholesterol Goals. Archives of Internal Medicine. https://doi.org/10.1001/archinte.160.4.459

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.