The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Treatment and Outcome of Staphylococcus aureus Bacteremia: A Prospective Study of 278 Cases
Abstract
BACKGROUND: Staphylococcus aureus bacteremia is still a serious problem, and the optimal treatment is under debate. Only a few studies concerning treatment are available. METHODS: The study population was all patients with a positive blood culture result for S aureus in Copenhagen County, Denmark, from May 1994 through April 1996. Of 278 patients with S aureus bacteremia, 186 were evaluated according to outcome in a prospective, observational follow-up study. The time above the minimum inhibitory concentration was estimated for dicloxacillin sodium for each treatment regimen and evaluated by logistic regression along with other potential risk factors. RESULTS: The following variables were statistically associated with death: the presence of an uneradicated focus (odds ratio [OR], 6.7; 95% confidence interval [CI], 2.1-21.0); the presence of septic shock (OR, 3.7; 95% CI, 1.5-9.1); the total daily dose of penicillinase-stable penicillin less than 4 g (OR, 3.7; 95% CI, 1.3-11.1); and age 60 years or older (OR, 2.4; 95% CI, 1.1-5.3). The following variables were significantly associated with recurrence: the total daily dose of penicillinase-stable penicillin less than 3 g (OR, 3.9; 95% CI, 1.6-10.0) and the presence of a secondary focus (OR, 3.2; 95% CI, 1.3-7.7). Among 155 patients with observation time longer than duration of treatment, this factor (duration of treatment, <14 days) was significantly related to mortality (OR, 0.84; 95% CI, 0.76-0.94). CONCLUSIONS: Focus eradication and the dosing of penicillinase-stable penicillin are important to the outcome of S aureus bacteremia. We recommend treatment with at least 1 g of penicillinase-stable penicillins 4 times daily for longer than 14 days.
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Cites
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Predictors of Mortality in Staphylococcus aureus Bacteremia
van Hal, S. J., Jensen, S. O., Vaska, V. L., Espedido, B. A., Paterson, D. L., & Gosbell, I. B. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05022-11 · Cited by 932
Clinical Identifiers of Complicated Staphylococcus aureus Bacteremia
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Miro, J. M., Anguera, I., Cabell, C. H., Chen, A. Y., Stafford, J. A., Corey, G. R., Olaison, L., Eykyn, S., Hoen, B., Abrutyn, E., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/431979 · Cited by 334
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Gómez, J., García-Vázquez, E., Baños, R., Canteras, M., Ruiz, J., Baños, V., Herrero, J. A., & Valdés, M. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0272-x · Cited by 81
Metadata
- Authors
- Jensen, A. G., Wachmann, C. H., Espersen, F., Scheibel, J., Skinhøj, P., & Frimodt-Møller, N.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2002-01-14
- Volume
- 162
- Issue
- 1
- Pages
- 25
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1997692689
- Cited by
- 270
- References
- 32
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
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