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Cited by 932

The DOI matches its Crossref record; 294 of the 294 references it cites were found in a registry or an index.

Predictors of Mortality in Staphylococcus aureus Bacteremia

Open access
van Hal, Sebastian J., Jensen, Slade O., Vaska, Vikram L., Espedido, Björn A., Paterson, David L., Gosbell, Iain B.·2012·Clinical Microbiology Reviews

Abstract

SUMMARY: Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these patients will die from SAB. Comparatively, this accounts for a greater number of deaths than for AIDS, tuberculosis, and viral hepatitis combined. Multiple factors influence outcomes for SAB patients. The most consistent predictor of mortality is age, with older patients being twice as likely to die. Except for the presence of comorbidities, the impacts of other host factors, including gender, ethnicity, socioeconomic status, and immune status, are unclear. Pathogen-host interactions, especially the presence of shock and the source of SAB, are strong predictors of outcomes. Although antibiotic resistance may be associated with increased mortality, questions remain as to whether this reflects pathogen-specific factors or poorer responses to antibiotic therapy, namely, vancomycin. Optimal management relies on starting appropriate antibiotics in a timely fashion, resulting in improved outcomes for certain patient subgroups. The roles of surgery and infectious disease consultations require further study. Although the rate of mortality from SAB is declining, it remains high. Future international collaborative studies are required to tease out the relative contributions of various factors to mortality, which would enable the optimization of SAB management and patient outcomes.

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Metadata

Authors
van Hal, S. J., Jensen, S. O., Vaska, V. L., Espedido, B. A., Paterson, D. L., & Gosbell, I. B.
Venue
Clinical Microbiology Reviews
Published
2012-04
Volume
25
Issue
2
Pages
362-386
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2161881689
Cited by
932
References
294
FWCI
21.05
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Predictors of Mortality in Staphylococcus aureus Bacteremia. https://app.cochat.ai/papers/10.1128/cmr.05022-11
The paper
van Hal, S. J., Jensen, S. O., Vaska, V. L., Espedido, B. A., Paterson, D. L., & Gosbell, I. B. (2012). Predictors of Mortality in Staphylococcus aureus Bacteremia. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.05022-11

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