Chronic Work Stress and Marital Dissolution Increase Risk of Posttrial Mortality in Men From the Multiple Risk Factor Intervention Trial
Abstract
Background Acute life stressors can trigger premature death, but the role of more enduring, chronic stressors is less clear. We evaluated men's mortality risk associated with number of different work stressors and marital dissolution during the Multiple Risk Factor Intervention Trial (MRFIT). Methods Men without definite evidence of coronary heart disease (CHD) at study entry but with above-average risk for CHD mortality based on blood pressure, serum cholesterol levels, and/or cigarette smoking were recruited into MRFIT. Survivors at the end of the trial were followed up for mortality for an additional 9 years. All 12,336 survivors who completed the work-event checklist at the annual evaluations during the trial were included in the analyses of work stressors, whereas the 10,904 who were married at the start of the trial were included in the analyses of marital dissolution. Results Increasing number of different work stressors and divorce during the trial were associated with total and cardiovascular mortality during the 9-year follow-up period (Ps Conclusion Work and marital stressors increase risk for mortality in men.
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Stressed persons are prone to developing premature coronary disease.
“Stressed persons are prone to viral infections, more frequent and severe flare-ups of asthma, multiple sclerosis, and arthritis, and to developing premature coronary disease (2–7).”
From A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling (2008) · cites this paper as [4]
Stressed persons have more frequent and severe flare-ups of asthma, multiple sclerosis, and arthritis.
“Stressed persons are prone to viral infections, more frequent and severe flare-ups of asthma, multiple sclerosis, and arthritis, and to developing premature coronary disease (2–7).”
From A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling (2008) · cites this paper as [4]
Stressed persons are prone to viral infections.
“Stressed persons are prone to viral infections, more frequent and severe flare-ups of asthma, multiple sclerosis, and arthritis, and to developing premature coronary disease (2–7).”
From A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling (2008) · cites this paper as [4]
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- Authors
- Matthews, K. A., & Gump, B. B.
- Affiliations
- University of Pittsburgh (US)
- State University of New York at Oswego (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2002-02-11
- Volume
- 162
- Issue
- 3
- Pages
- 309
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1977610327
- Cited by
- 228
- References
- 4
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 18 · 2018: 11 · 2017: 12 · 2016: 7 · 2015: 5 · 2014: 11 · 2013: 10 · 2012: 5
- FWCI
- 21.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL65111, HL65112, P50HL065112, P50HL065111)
- Topics
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- chronic occupational stress, divorce, cardiovascular mortality, all-cause mortality, men, Multiple Risk Factor Intervention Trial, coronary heart disease risk, life events, occupational stressors
- MeSH terms
- Adult, Analysis of Variance, Divorce, Humans, Interpersonal Relations, Life Change Events, Male, Middle Aged, Risk Factors, Sensitivity and Specificity, Stress, Psychological, Time Factors, United States, Cohort Studies, Confidence Intervals, Linear Models, Proportional Hazards Models, Workload, Marital Status, Risk Assessment
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