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Cited by 930Alcohol Consumption and Health EffectsSubstance Abuse Treatment and OutcomesNutritional Studies and Diet

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Alcohol Dosing and Total Mortality in Men and Women: An Updated Meta-analysis of 34 Prospective Studies

Di Castelnuovo, Augusto·2006·Archives of Internal Medicine
DOI 10.1001/archinte.166.22.2437
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Abstract

BACKGROUND: Moderate consumption of alcohol is inversely related with coronary disease, but its association with mortality is controversial. We performed a meta-analysis of prospective studies on alcohol dosing and total mortality. METHODS: We searched PubMed for articles available until December 2005, supplemented by references from the selected articles. Thirty-four studies on men and women, for a total of 1 015 835 subjects and 94 533 deaths, were selected. Data were pooled with a weighed regression analysis of fractional polynomials. RESULTS: A J-shaped relationship between alcohol and total mortality was confirmed in adjusted studies, in both men and women. Consumption of alcohol, up to 4 drinks per day in men and 2 drinks per day in women, was inversely associated with total mortality, maximum protection being 18% in women (99% confidence interval, 13%-22%) and 17% in men (99% confidence interval, 15%-19%). Higher doses of alcohol were associated with increased mortality. The inverse association in women disappeared at doses lower than in men. When adjusted and unadjusted data were compared, the maximum protection was only reduced from 19% to 16%. The degree of association in men was lower in the United States than in Europe. CONCLUSIONS: Low levels of alcohol intake (1-2 drinks per day for women and 2-4 drinks per day for men) are inversely associated with total mortality in both men and women. Our findings, while confirming the hazards of excess drinking, indicate potential windows of alcohol intake that may confer a net beneficial effect of moderate drinking, at least in terms of survival.

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Metadata

Authors
Di Castelnuovo, A.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2006-12-11
Volume
166
Issue
22
Pages
2437
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.166.22.2437
OpenAlex
W2149650579
Cited by
930
References
58
Citations by year
2026: 19 · 2025: 28 · 2024: 29 · 2023: 31 · 2022: 47 · 2021: 53 · 2020: 45 · 2019: 46 · 2018: 57 · 2017: 53 · 2016: 57 · 2015: 68 · 2014: 68 · 2013: 52 · 2012: 71
FWCI
21.08
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
alcohol consumption, all-cause mortality, moderate drinking, J-shaped relationship, sex differences, alcohol dose-response, coronary disease
MeSH terms
Alcohol Drinking, Alcoholic Intoxication, Dose-Response Relationship, Drug, Europe, Female, Humans, Male, Prospective Studies, Socioeconomic Factors, United States, Logistic Models, Survival Analysis

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