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Cited by 485

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Obesity, Waist Circumference, Weight Change, and the Risk of Psoriasis in Women: Nurses' Health Study II

Setty, Arathi R.·2007·Archives of Internal Medicine

Abstract

BACKGROUND: Psoriasis is a common, chronic, inflammatory skin disorder. Higher adiposity may increase the risk of psoriasis, but, to our knowledge, no prospective data are available on this relationship. METHODS: We prospectively examined the relationships between body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight change, waist circumference, hip circumference, waist-hip ratio, and incident psoriasis in 78 626 women over a 14-year period (1991-2005) in the Nurses' Health Study II. The primary outcome was incident, self-reported, physician-diagnosed psoriasis. RESULTS: During the 14 years of follow-up, there were 892 self-reported incident cases of psoriasis. There was a graded positive association between BMI measured at multiple time points and the risk of incident psoriasis. When we analyzed BMI updated every 2 years, compared with a BMI of 21.0 through 22.9, the multivariate relative risks of psoriasis were 1.40 (95% confidence interval [CI], 1.13-1.73) for a BMI of 25.0 through 29.9; 1.48 (95% CI, 1.15-1.91) for a BMI of 30.0 through 34.9; and 2.69 (95% CI, 2.12-3.40) for a BMI of 35.0 or greater (P for trend, < .001). For BMI at the age of 18 years, the multivariate relative risk for the top BMI category (> or = 30.0) was 1.73 (95% CI, 1.24-2.41) and that for a lower BMI category (< 21.0) was 0.76 (95% CI, 0.65-0.90) (P for trend, < .001). Weight gain from the age of 18 years, higher waist circumference, hip circumference, and waist-hip ratio were all associated with a higher risk of incident psoriasis (all P values for trend, < .001). CONCLUSION: This large prospective study indicates that increased adiposity and weight gain are strong risk factors for incident psoriasis in women.

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Metadata

Authors
Setty, A. R.
Venue
Archives of Internal Medicine
Published
2007-08-13
Volume
167
Issue
15
Pages
1670
ISSN
0003-9926 (ISSN-L)
OpenAlex
W1991748889
Cited by
485
References
29
FWCI
8.99
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Obesity, Waist Circumference, Weight Change, and the Risk of Psoriasis in Women: Nurses' Health Study II. https://app.cochat.ai/papers/10.1001/archinte.167.15.1670
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Setty, A. R. (2007). Obesity, Waist Circumference, Weight Change, and the Risk of Psoriasis in Women: Nurses' Health Study II. Archives of Internal Medicine. https://doi.org/10.1001/archinte.167.15.1670

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