The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Obesity predisposes to Th17 bias
Abstract
Obesity is associated with numerous inflammatory conditions including atherosclerosis, autoimmune disease and cancer. Although the precise mechanisms are unknown, obesity‐associated rises in TNF‐α, IL‐6 and TGF‐β are believed to contribute. Here we demonstrate that obesity selectively promotes an expansion of the Th17 T‐cell sublineage, a subset with prominent pro‐inflammatory roles. T‐cells from diet‐induced obese mice expand Th17 cell pools and produce progressively more IL‐17 than lean littermates in an IL‐6‐dependent process. The increased Th17 bias was associated with more pronounced autoimmune disease as confirmed in two disease models, EAE and trinitrobenzene sulfonic acid colitis. In both, diet‐induced obese mice developed more severe early disease and histopathology with increased IL‐17+ T‐cell pools in target tissues. The well‐described association of obesity with inflammatory and autoimmune disease is mechanistically linked to a Th17 bias.
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
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IL-17 family cytokines and the expanding diversity of effector T cell lineages
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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
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IL-23 promotes tumour incidence and growth
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IL-21 and TGF-β are required for differentiation of human TH17 cells
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Cited by
Th17 and regulatory T cells in mediating and restraining inflammation
Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882
Obesity in autoimmune diseases: Not a passive bystander
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 532
Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 466
Metadata
- Authors
- Winer, S., Paltser, G., Chan, Y., Tsui, H., Engleman, E., Winer, D., & Dosch, H. ‐.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2009-08-27
- Volume
- 39
- Issue
- 9
- Pages
- 2629-2635
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2018192258
- Cited by
- 377
- References
- 22
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Winer, S., Paltser, G., Chan, Y., Tsui, H., Engleman, E., Winer, D., & Dosch, H. ‐. (2009). Obesity predisposes to Th17 bias. European Journal of Immunology. https://doi.org/10.1002/eji.200838893
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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