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Cited by 109Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismNutritional Studies and Diet

Studies on serum cholesterol and other characteristics of clinically healthy men in Naples

KEYS, ANCEL·1954·Archives of Internal Medicine
DOI 10.1001/archinte.1954.00240270014002
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Abstract

IN THE control of the concentration of blood cholesterol the diet clearly has a marked and ubiquitous effect, but the picture differs in various species. Man does not compare with the rabbit and the chick in sensitivity to exogenous cholesterol, but his response to total fats in the diet appears to be greater.* Obviously, quantitative information on the effect of the diet on the blood cholesterol level in man must be sought from man himself. Experiments on this problem in man generally have several defects. The studies reported so far have largely ignored the important factor of age7and have been limited to a few weeks or months of drastic change from previous lifelong subsistence on the relatively high-fat diet that is almost universally used in the United States at the present time. The present paper reports findings on clinically healthy men in Naples, where the habitual diet, like

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Crossref · 10.1001/archinte.1954.00240270014002

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  • In many but not all of the 22 countries bordering the Mediterranean Sea, a great abundance and diversity of nonstarchy vegetables, minimally processed whole-grain cereals, legumes, nuts, and seeds were staple foods for both men and women.

    “Historically, in many but not all of the 22 countries bordering the Mediterranean Sea, a great abundance and diversity of nonstarchy vegetables, minimally processed whole-grain cereals, legumes, nuts, and seeds were staple foods for both men and women (Table 1).”

    From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [2]

  • The incidence of coronary heart disease and certain cancers, which was very low in Mediterranean countries, has increased substantially.

    “Consistently the incidence of coronary heart disease and certain cancers, which was very low in those countries, has increased substantially (1,2,4).”

    From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [2]

  • In Southern Italy in the 1950s, very little meat was eaten, typically only once every week or two, and milk was never used except in coffee or for infants.

    “For example, in Southern Italy in the 1950s, very little meat was eaten, typically only once every week or two, and milk was never used except in coffee (caffé macchiato) or for infants.”

    From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [2]

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Authors
KEYS, A.
Corresponding author
KEYS, ANCEL
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
1954-03-01
Volume
93
Issue
3
Pages
328
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.1954.00240270014002
OpenAlex
W2064571916
Cited by
109
References
23
Citations by year
2026: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 1
FWCI
47.27
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
serum cholesterol, dietary fat, healthy men, high-fat diet
MeSH terms
Blood, Cholesterol, Humans, Male, Men's Health

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