CoChat
Sign Up
Cited by 45Infective Endocarditis Diagnosis and ManagementAntimicrobial Resistance in StaphylococcusStreptococcal Infections and Treatments

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Combination Antibiotic Therapy in Staphylococcal Endocarditis: The Use of Methicillin Sodium-Gentamicin Sulfate Therapy

Murray, Henry W.·1976·Archives of Internal Medicine
DOI 10.1001/archinte.1976.03630040082017
Open this paper in CoChat — free account

Abstract

The well-demonstrated in vitro synergism of penicillin and aminoglycoside antibiotics against various groups of streptococci,1-6and their in vivo efficacy in the treatment of endocarditis caused byStreptococcus viridansand enterococci have been the subject of continued interest.6-13Importantly, Durack et al8and Sande and Irvin14have demonstrated a definite in vivo correlation with in vitro penicillin-aminoglycoside synergism in animals with aS viridansendocarditis model. Recently, a similar correlation also has been demonstrated with the use of aStaphylococcus aureusendocarditis model and penicillin-gentamicin therapy.15The clinical importance of combination therapy in serious infections such as endocarditis lies in its enhancement of bacterial killing, and, thus, in its prevention of further vital tissue destruction. We report a patient with endocarditis caused by a methicillin-sensitiveS aureusin which the clinical response to methicillin sodium treatment alone was not satisfactory. The addition of gentamicin sulfate

Overview

Integrity signals

Registry

Crossref · 10.1001/archinte.1976.03630040082017

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Metadata

Authors
Murray, H. W.
Affiliations
Johns Hopkins University (US)
Corresponding author
Murray, Henry W.
ORCID
Murray, Henry W.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
1976-04-01
Volume
136
Issue
4
Pages
480
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.1976.03630040082017
OpenAlex
W2010055793
Cited by
45
References
30
Citations by year
2021: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2013: 1
FWCI
7.33
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords
staphylococcal endocarditis, Staphylococcus aureus, combination antibiotic therapy, gentamicin, methicillin, methicillin-susceptible Staphylococcus aureus
MeSH terms
Drug Therapy, Combination, Endocarditis, Bacterial, Gentamicins, Humans, Male, Methicillin, Middle Aged, Staphylococcal Infections, Staphylococcus aureus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review