Cited by 1,108Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementCardiovascular and Diving-Related Complications

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Atrial Fibrillation: A Major Contributor to Stroke in the Elderly: The Framingham Study

Wolf, Philip A.·1987·Archives of Internal Medicine

DOI 10.1001/archinte.1987.00370090041008

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Abstract

• Chronic atrial fibrillation without valvular disease has been associated with increased stroke incidence. The impact of atrial fibrillation on the risk of stroke with increasing age was examined in 5184 men and women in the Framingham Heart Study. After 30 years of follow-up, chronic atrial fibrillation appeared in 303 persons. Age-specific incidence rates steadily increased from 0.2 per 1000 for ages 30 to 39 years to 39.0 per 1000 for ages 80 to 89 years. The proportion of strokes associated with this arrhythmia was 14.7%, 68 of the total 462 initial strokes, increasing steadily with age from 6.7% for ages 50 to 59 years to 36.2% for ages 80 to 89 years. In contrast to the impact of cardiac failure, coronary heart disease, and hypertension, which declined with age, atrial fibrillation was a significant contributor to stroke at all ages. (Arch Intern Med1987;147:1561-1564)

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ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation31This document was approved by the American College of Cardiology Board of Trustees in August 2001, the American Heart Association Science Advisory and Coordinating Committee in August 2001, and the European Society of Cardiology Board and Committee for Practice Guidelines and Policy Conferences in August 2001.32When citing this document, the American College of Cardiology, the American Heart Association, and the European Society of Cardiology would appreciate the following citation format: Fuster V, Rydén LE, Asinger RW, Cannom DS, Crijns HJ, Frye RL, Halperin JL, Kay GN, Klein WW, Lévy S, McNamara RL, Prystowsky EN, Wann LS, Wyse DG. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation). J Am Coll Cardiol 2001;38:XX-XX.33This document is available on the World Wide Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), the European Society of Cardiology (www.escardio.org), and the North American Society of Pacing and Electrophysiology (www.naspe.org). Single reprints of this document (the complete Guidelines) to be published in the mid-October issue of the European Heart Journal are available by calling +44.207.424.4200 or +44.207.424.4389, faxing +44.207.424.4433, or writing Harcourt Publishers Ltd, European Heart Journal, ESC Guidelines – Reprints, 32 Jamestown Road, London, NW1 7BY, United Kingdom. Single reprints of the shorter version (Executive Summary and Summary of Recommendations) published in the October issue of the Journal of the American College of Cardiology and the October issue of Circulation, are available for $5.00 each by calling 800-253-4636 (US only) or by writing the Resource Center, American College of Cardiology, 9111 Old Georgetown Road, Bethesda, Maryland 20814. To purchase bulk reprints specify version and reprint number (Executive Summary 71-0208; full text 71-0209) up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 214-706-1466, fax 214-691-6342; or E-mail: pubauth@heart.org.
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Authors: Wolf, P. A.
Corresponding author: Wolf, Philip A.
ORCID: Wolf, Philip A.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1987-09-01
Volume: 147
Issue: 9
Pages: 1561
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1987.00370090041008
OpenAlex: W4292280632
Cited by: 1,108
References: 0
Citations by year: 2026: 5 · 2025: 16 · 2024: 25 · 2023: 22 · 2022: 19 · 2021: 27 · 2020: 34 · 2019: 36 · 2018: 47 · 2017: 38 · 2016: 63 · 2015: 62 · 2014: 47 · 2013: 57 · 2012: 45
FWCI: 4.73
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (1-RO1-NS-17950-01, N01 NS2 2398, IPO-INS-16367)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Keywords: atrial fibrillation, stroke, older adults, stroke risk factors, Framingham Heart Study, cardiac arrhythmias, cardiovascular disease

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Atrial Fibrillation: A Major Contributor to Stroke in the Elderly: The Framingham Study

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