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Atrial Fibrillation: A Major Contributor to Stroke in the Elderly: The Framingham Study
Abstract
• Chronic atrial fibrillation without valvular disease has been associated with increased stroke incidence. The impact of atrial fibrillation on the risk of stroke with increasing age was examined in 5184 men and women in the Framingham Heart Study. After 30 years of follow-up, chronic atrial fibrillation appeared in 303 persons. Age-specific incidence rates steadily increased from 0.2 per 1000 for ages 30 to 39 years to 39.0 per 1000 for ages 80 to 89 years. The proportion of strokes associated with this arrhythmia was 14.7%, 68 of the total 462 initial strokes, increasing steadily with age from 6.7% for ages 50 to 59 years to 36.2% for ages 80 to 89 years. In contrast to the impact of cardiac failure, coronary heart disease, and hypertension, which declined with age, atrial fibrillation was a significant contributor to stroke at all ages. (Arch Intern Med1987;147:1561-1564)
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“Twenty-five percent of ischemic strokes remain unexplained after an initial thorough evaluation including 12-lead ECG and in-hospital telemetry monitoring and full neurological workup, that is,”
From 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (2017) · cites this paper as Wolf et al., 1987
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Metadata
- Authors
- Wolf, P. A.
- Corresponding author
- Wolf, Philip A.
- ORCID
- Wolf, Philip A.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1987-09-01
- Volume
- 147
- Issue
- 9
- Pages
- 1561
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W4292280632
- Cited by
- 1,108
- References
- 0
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 25 · 2023: 22 · 2022: 19 · 2021: 27 · 2020: 34 · 2019: 36 · 2018: 47 · 2017: 38 · 2016: 63 · 2015: 62 · 2014: 47 · 2013: 57 · 2012: 45
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (1-RO1-NS-17950-01, N01 NS2 2398, IPO-INS-16367)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- atrial fibrillation, stroke, older adults, stroke risk factors, Framingham Heart Study, cardiac arrhythmias, cardiovascular disease
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