Is Silent Thyroiditis an Autoimmune Disease?
Abstract
The entity of silent (painless) thyroiditis has been recognized over the past decade as a clinical syndrome manifested by transient hyperthyroidism associated with a marked depression of the thyroidal radioactive iodine uptake, often followed by a transient period of hypothyroidism, but most patients ultimately recover to normal.1The similarity of the thyroid dysfunction and the evolution during the course of the disease in silent thyroiditis to the picture seen in de Quervain's subacute thyroiditis brought with it the possibility that silent thyroiditis might share a similar cause with de Quervain's thyroiditis, namely, a possible viral infection.1-4However, a number of elements argue against that possibility. See also p 1974. First, the histologic appearance of the thyroid gland in this condition shows lymphocytic infiltration reminiscent of Hashimoto's thyroiditis. It is not identical with typical Hashimoto's thyroiditis, however, since there are few lymphoid follicles, few or no Hürthle cells are
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Painless thyroiditis is probably an autoimmune disease manifested by positive anti-thyroid peroxidase antibodies in about 50% of patients and findings of lymphocytic infiltration on pathology.
“Painless thyroiditis is probably an autoimmune disease manifested by positive anti-thyroid peroxidase antibodies in about 50% of patients and findings of lymphocytic infiltration on pathology (626,627).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [627]
Cites
An Outbreak of Thyrotoxicosis Caused by the Consumption of Bovine Thyroid Gland in Ground Beef
Hedberg, C. W., Fishbein, D. B., Janssen, R. S., Meyers, B., McMillen, J. M., MacDonald, K. L., White, K. E., Huss, L. J., Hurwitz, E. S., Farhie, J. R., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704163161605 · Cited by 130 · see citing works
Thyrotoxicosis with painless thyroiditis
Woolf, P. D., & Daly, R. G. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90535-0 · Cited by 104 · see citing works
Jansson, R., Säfwenberg, J., & Dahlberg, P. A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-168 · Cited by 85 · see citing works
Transient Hyperthyroidism in Patients With Lymphocytic Thyroiditis
Gorman, C. A., Duick, D. S., Woolner, L. B., et al. (1978) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)38075-4 · Cited by 37 · see citing works
Typical and Atypical ('Silent') Subacute Thyroiditis in a Wife and Husband
Morrison, J. L. (1978) · Archives of Internal Medicine · doi:10.1001/archinte.1978.03630250029012 · Cited by 32 · see citing works
Clinical Course of Silent Thyroiditis in a Patient With Sjögren's Syndrome
Mitani, Y. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380090058016 · Cited by 11 · see citing works
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
“Painless thyroiditis is probably an autoimmune disease manifested by positive anti–thyroid peroxidase antibodies in about 50% of patients and findings of lymphocytic infiltration on pathology (626,627).”
Background
- Authors
- Volpé, R.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1988-09-01
- Volume
- 148
- Issue
- 9
- Pages
- 1907
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2072120057
- Cited by
- 24
- References
- 6
- Citations by year
- 2026: 1 · 2018: 2 · 2016: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- silent thyroiditis, autoimmune thyroid disease, transient hyperthyroidism, transient hypothyroidism, radioiodine uptake, viral etiology, lymphocyte infiltration, Hashimoto's thyroiditis, Hürthle cells, thyroid histopathology
- MeSH terms
- Diagnosis, Differential, Humans, Thyroiditis, Thyroiditis, Autoimmune
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