Cyclosporine-Associated Hypertension
Abstract
Widespread availability of the fungal endecapeptide cyclosporine in 1983 ushered in an era of improved success and broader application of organ transplantation. In 1985, a review1of the clinical results with immunosuppression using cyclosporine identified nephrotoxic reactions as the most serious adverse effect of cyclosporine2; a 50% incidence of hypertension was also recognized and thought to be more frequent than with previous immunosuppressive regimens. The cause was unknown, and further investigation was encouraged. Other autoimmune diseases, such as psoriasis, primary biliary cirrhosis, rheumatoid arthritis, and type I diabetes mellitus, have been treated successfully with cyclosporine but with similar complications.3 The purpose of this report is to alert the practicing physician regarding these issues and to provide guidance in treating patients. In addition to incidence, the characteristics of cyclosporine-associated hypertension (CAH) will be reviewed along with data supporting various speculated mechanisms. Drug management of CAH and further directions
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Hypertension is reported in the majority of patients undergoing renal, hepatic, or heart transplantation treated with cyclosporine.
“Hypertension is reported in the majority of patients undergoing renal, hepatic, or heart transplantation treated with cyclosporine.218”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [218]
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Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
- Authors
- Porter, G. A.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1990-02-01
- Volume
- 150
- Issue
- 2
- Pages
- 280
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2134270225
- Cited by
- 90
- References
- 39
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 1
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- cyclosporine, drug-induced hypertension, immunosuppression, organ transplantation, nephrotoxicity, adverse drug reactions, autoimmune disease, antihypertensive therapy
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