Cited by 190Vibrio bacteria research studiesInfections and bacterial resistanceIron Metabolism and Disorders

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Hemochromatosis, Iron, and Septicemia Caused by Vibrio vulnificus

Bullen, John J.·1991·Archives of Internal Medicine

DOI 10.1001/archinte.1991.00400080096018

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Abstract

Vibrio vulnificus is killed by normal human blood but grows rapidly in blood from patients with hemochromatosis. It also grows in normal blood if the saturation of the transferrin is increased or if hematin, which contains iron, is added. It is suggested that the increased availability of iron in the blood of patients with chronic iron overload is responsible for their enhanced susceptibility to infection with V vulnificus.

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“The higher susceptibility in patients with cirrhosis is attributed to decreased serum bactericidal activity, impaired hepatic filtration, and high serum iron levels that promote bacterial proliferation [7].”

Authors: Bullen, J. J.
Affiliations: University of Miami (US)
Corresponding author: Bullen, John J.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1991-08-01
Volume: 151
Issue: 8
Pages: 1606
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1991.00400080096018
OpenAlex: W1998616787
Semantic Scholar: ad2466c97dc95a56572caa2fd685aab9f096f40f
Cited by: 190
References: 19
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 5 · 2017: 8 · 2016: 2 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 8
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Vibrio bacteria research studies
Health Sciences › Medicine › Microbiology (medical) › Infections and bacterial resistance
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: hemochromatosis, Vibrio vulnificus, septicemia, iron overload, transferrin saturation, hematin, iron availability, chronic iron overload
MeSH terms: Female, Hemochromatosis, Hemoglobins, Humans, Iron, Male, Molecular Weight, Reference Values, Transferrin, Vibrio Infections, Sepsis, In Vitro Techniques

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Hemochromatosis, Iron, and Septicemia Caused by Vibrio vulnificus

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