The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Hemochromatosis, Iron, and Septicemia Caused by Vibrio vulnificus
Abstract
Vibrio vulnificus is killed by normal human blood but grows rapidly in blood from patients with hemochromatosis. It also grows in normal blood if the saturation of the transferrin is increased or if hematin, which contains iron, is added. It is suggested that the increased availability of iron in the blood of patients with chronic iron overload is responsible for their enhanced susceptibility to infection with V vulnificus.
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“Induction of hypoferremia, via systemic inhibition of extracellular Fe export coupled to increased Mø Fe/heme uptake and intracellular retention [5,6], reduces the growth and virulence of extracellular pathogens, as illustrated for Vibrio vulnificus infection in mice [96,97].”
From The Iron age of host–microbe interactions (2015) · cites this paper as [97]
Citations
Cites
The estimation of the bactericidal power of the blood
Miles, A. A., Misra, S. S., & Irwin, J. O. (1938) · Epidemiology and Infection · doi:10.1017/s002217240001158x · Cited by 3,619
Disease Caused by a Marine Vibrio
Blake, P. A., MERSON, M. H., Weaver, R. E., Hollis, D. G., & Heublein, P. C. (1979) · New England Journal of Medicine · doi:10.1056/nejm197901043000101 · Cited by 632
Role of Iron in Bacterial Infection
Bullen, J. J., Rogers, H. J., & Griffiths, E. (1978) · Modern aspects of electrochemistry · doi:10.1007/978-3-642-66956-9_1 · Cited by 494
Self-citationCurrent perspectives on the epidemiology and pathogenesis of clinically significant Vibrio spp
Janda, J. M., Powers, C., Bryant, R. G., & Abbott, S. L. (1988) · Clinical Microbiology Reviews · doi:10.1128/cmr.1.3.245 · Cited by 433
Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis
Grootveld, M. C., Bell, J. D., Halliwell, B. B., Aruoma, O. I., Bomford, A. B., & Sadler, P. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83758-9 · Cited by 404
The specific binding of iron(III) and copper(II) to transferrin and conalbumin
Aasa, R., Malmström, B. G., Saltman, P., & Vänngård, T. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)90599-7 · Cited by 366
Role of iron in the pathogenesis of Vibrio vulnificus infections
Wright, A. C., Simpson, L. M., & Oliver, J. D. (1981) · Infection and Immunity · doi:10.1128/iai.34.2.503-507.1981 · Cited by 343
Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis
Gutteridge, J. M. C., Rowley, D. A., Griffiths, E., & Halliwell, B. B. (1985) · Clinical Science · doi:10.1042/cs0680463 · Cited by 269
Detection of extracellular toxin(s) produced by Vibrio vulnificus
Kreger, A. S., & Lockwood, D. (1981) · Infection and Immunity · doi:10.1128/iai.33.2.583-590.1981 · Cited by 200
Iron Overload Disorders: Natural History, Pathogenesis, Diagnosis, and Therapy
McLaren, G. D., Muir, W., Kellermeyer, R. W., & Jacobs, A. (1983) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368309165764 · Cited by 189
Cited by
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The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts
Skaar, E. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000949 · Cited by 796
“vulnificus is killed by normal blood and rarely causes infection in healthy individuals, it grows rapidly in blood from patients with hemochromatosis, leading to a high risk of fatal infections in this cohort [4].”
BackgroundIron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
“In vivo, reduced cytokine production is associated with attenuated inflammatory response to Salmonella infection (160), revealing an underlying cause for susceptibility of patients with Type I hemochromatosis to infections such as Salmonella, Vibrio, and Yersinia (10, 28).”
BackgroundMolecular mechanisms of Vibrio parahaemolyticus pathogenesis
Li, L., Meng, H., Gu, D., Li, Y., & Jia, M. (2019) · Microbiological Research · doi:10.1016/j.micres.2019.03.003 · Cited by 287
Sequestration and scavenging of iron in infection
Parrow, N. L., Fleming, R. E., & Minnick, M. F. (2013) · Infection and Immunity · doi:10.1128/iai.00602-13 · Cited by 261
Olynyk, J. K., Reddy, K. R., Bisceglie, A. M. D., Jeffers, L. J., Parker, T., Radick, J. L., Schiff, E. R., & Bacon, B. R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90209-0 · Cited by 252
Metadata
- Authors
- Bullen, J. J.
- Affiliations
- University of Miami (US)
- Corresponding author
- Bullen, John J.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1991-08-01
- Volume
- 151
- Issue
- 8
- Pages
- 1606
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1998616787
- Semantic Scholar
- ad2466c97dc95a56572caa2fd685aab9f096f40f
- Cited by
- 190
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 5 · 2017: 8 · 2016: 2 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 8
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Vibrio bacteria research studies
- Health Sciences › Medicine › Microbiology (medical) › Infections and bacterial resistance
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- hemochromatosis, Vibrio vulnificus, septicemia, iron overload, transferrin saturation, hematin, iron availability, chronic iron overload
- MeSH terms
- Female, Hemochromatosis, Hemoglobins, Humans, Iron, Male, Molecular Weight, Reference Values, Transferrin, Vibrio Infections, Sepsis, In Vitro Techniques
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