The management of diabetes insipidus in adults
Abstract
The management of patients with diabetes insipidus can be confusing because of the disorder's variable pathophysiology, the numerous medications used, and the possible complications related to their use. Nevertheless, the primary care physician, rather than the subspecialist, will increasingly be called on to manage patients with such relatively uncommon conditions in the future. If a few basic facts and principles are kept in mind, the care of most patients with diabetes insipidus can be successful. A comprehensive, practical review of the short- and long-term therapy for patients with diabetes insipidus, including central diabetes insipidus, nephrogenic diabetes insipidus, and the "excessive vasopressinase syndrome," is presented. The use of single and multidrug regimens, and of the newly marketed oral formulation of desmopressin acetate, is described for common clinical settings.
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PACK has been successfully implemented in several low- and middle-income countries, including South Africa, Botswana, Brazil, Nigeria and Ethiopia.
“PACK has been successfully implemented in several LMICs, including South-Africa, Botswana, Brazil, Nigeria and Ethiopia.319”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [319]
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- Authors
- Singer, I.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Singer, Irwin
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1997-06-23
- Volume
- 157
- Issue
- 12
- Pages
- 1293
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2090565672
- Cited by
- 78
- References
- 32
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 2
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- diabetes insipidus, central diabetes insipidus, nephrogenic diabetes insipidus, desmopressin acetate, vasopressin, antidiuretic therapy, primary care management, pharmacotherapy
- MeSH terms
- Acute Disease, Adult, Chronic Disease, Diabetes Insipidus, Diagnosis, Differential, Female, Humans, Male, Middle Aged
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