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Cited by 468Pancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchGallbladder and Bile Duct Disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis

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Yadav, Dhiraj·2009·Archives of Internal Medicine
DOI 10.1001/archinternmed.2009.125PMC PMC6785300
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Abstract

BACKGROUND: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, and effects of alcohol and smoking may be limited to specific patient subsets. We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers. METHODS: The North American Pancreatitis Study 2, a multicenter consortium of 20 US centers, prospectively enrolled 540 patients with CP, 460 patients with RAP, and 695 controls from 2000 to 2006. Using self-reported monthly alcohol consumption during the maximum lifetime drinking period, we classified subjects by drinking status: abstainer, light drinker (< or =0.5 drink per day), moderate drinker (women, >0.5 to 1 drink per day; men, >0.5 to 2 drinks per day), heavy drinker (women, >1 to <5 drinks per day; men, >2 to <5 drinks per day), or very heavy drinker (> or =5 drinks per day for both sexes). Smoking was classified as never, past, or current and was quantified (packs per day and pack-years). RESULTS: Overall, participants' mean (SD) age was 49.7 (15.4) years; 87.5% were white, and 56.5% were women. Approximately one-fourth of both controls and patients were lifetime abstainers. The prevalence of very heavy drinking among men and women was 38.4% and 11.0% for CP, 16.9% and 5.5% for RAP, and 10.0% and 3.6% for controls. Compared with abstaining and light drinking, very heavy drinking was significantly associated with CP (odds ratio, 3.10; 95% confidence interval, 1.87-5.14) after controlling for age, sex, smoking status, and body mass index. Cigarette smoking was an independent, dose-dependent risk factor for CP and RAP. CONCLUSIONS: Very heavy alcohol consumption and smoking are independent risks for CP. A minority of patients with pancreatitis currently seen at US referral centers report very heavy drinking.

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Metadata

Authors
Yadav, D.
Affiliations
University of Pittsburgh (US)
Corresponding author
Yadav, Dhiraj
ORCID
Yadav, Dhiraj
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2009-06-08
Volume
169
Issue
11
Pages
1035
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinternmed.2009.125
PMC
PMC6785300
OpenAlex
W2096677890
Cited by
466
References
38
Citations by year
2026: 14 · 2025: 20 · 2024: 22 · 2023: 25 · 2022: 26 · 2021: 36 · 2020: 30 · 2019: 30 · 2018: 31 · 2017: 39 · 2016: 28 · 2015: 32 · 2014: 30 · 2013: 22 · 2012: 28
FWCI
26.97
Type
journal article
Language
en
Open access
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (- DK061451, R01DK061451, R56DK061451)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
Keywords
recurrent acute pancreatitis, chronic pancreatitis, alcohol consumption, heavy drinking, cigarette smoking, smoking as risk factor, alcohol use prevalence, dose-response relationship, risk factors
MeSH terms
Acute Disease, Alcohol Drinking, Chronic Disease, Female, Humans, Male, Middle Aged, Pancreatitis, Recurrence, Risk Factors, Smoking

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