The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis
Open accessAbstract
BACKGROUND: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, and effects of alcohol and smoking may be limited to specific patient subsets. We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers. METHODS: The North American Pancreatitis Study 2, a multicenter consortium of 20 US centers, prospectively enrolled 540 patients with CP, 460 patients with RAP, and 695 controls from 2000 to 2006. Using self-reported monthly alcohol consumption during the maximum lifetime drinking period, we classified subjects by drinking status: abstainer, light drinker (< or =0.5 drink per day), moderate drinker (women, >0.5 to 1 drink per day; men, >0.5 to 2 drinks per day), heavy drinker (women, >1 to <5 drinks per day; men, >2 to <5 drinks per day), or very heavy drinker (> or =5 drinks per day for both sexes). Smoking was classified as never, past, or current and was quantified (packs per day and pack-years). RESULTS: Overall, participants' mean (SD) age was 49.7 (15.4) years; 87.5% were white, and 56.5% were women. Approximately one-fourth of both controls and patients were lifetime abstainers. The prevalence of very heavy drinking among men and women was 38.4% and 11.0% for CP, 16.9% and 5.5% for RAP, and 10.0% and 3.6% for controls. Compared with abstaining and light drinking, very heavy drinking was significantly associated with CP (odds ratio, 3.10; 95% confidence interval, 1.87-5.14) after controlling for age, sex, smoking status, and body mass index. Cigarette smoking was an independent, dose-dependent risk factor for CP and RAP. CONCLUSIONS: Very heavy alcohol consumption and smoking are independent risks for CP. A minority of patients with pancreatitis currently seen at US referral centers report very heavy drinking.
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“The pathogenesis is different for acute and chronic pancreatitis, but alcohol use has a significant impact on the pathophysiology of both 298, 299, 300, 301, 302 and in the transition from acute to chronic pancreatitis (see 303 ).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [298]
In the citing paper
“Avoidance of alcohol by patients with FCS is important, as it may cause acute exaggerated TG elevations and exacerbations of acute pancreatitis episodes.7,36”
From Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span (2018) · cites this paper as [36]
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Metadata
- Authors
- Yadav, D.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Yadav, Dhiraj
- ORCID
- Yadav, Dhiraj
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2009-06-08
- Volume
- 169
- Issue
- 11
- Pages
- 1035
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC6785300
- OpenAlex
- W2096677890
- Cited by
- 466
- References
- 38
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 22 · 2023: 25 · 2022: 26 · 2021: 36 · 2020: 30 · 2019: 30 · 2018: 31 · 2017: 39 · 2016: 28 · 2015: 32 · 2014: 30 · 2013: 22 · 2012: 28
- FWCI
- 26.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (- DK061451, R01DK061451, R56DK061451)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
- Keywords
- recurrent acute pancreatitis, chronic pancreatitis, alcohol consumption, heavy drinking, cigarette smoking, smoking as risk factor, alcohol use prevalence, dose-response relationship, risk factors
- MeSH terms
- Acute Disease, Alcohol Drinking, Chronic Disease, Female, Humans, Male, Middle Aged, Pancreatitis, Recurrence, Risk Factors, Smoking
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