The Epidemiology of Pancreatitis and Pancreatic Cancer
Open accessAbstract
Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces patients' quality of life. Pancreatic cancer is associated with a high mortality rate and is one of the top 5 causes of death from cancer. The burden of pancreatic disorders is expected to increase over time. The risk and etiology of pancreatitis differ with age and sex, and all pancreatic disorders affect the black population more than any other race. Gallstones are the most common cause of acute pancreatitis, and early cholecystectomy eliminates the risk of future attacks. Alcohol continues to be the single most important risk factor for chronic pancreatitis. Smoking is an independent risk factor for acute and chronic pancreatitis, and its effects could synergize with those of alcohol. Significant risk factors for pancreatic cancer include smoking and non-O blood groups. Alcohol abstinence and smoking cessation can alter the progression of pancreatitis and reduce recurrence; smoking cessation is the most effective strategy to reduce the risk of pancreatic cancer.
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Preexisting acute pancreatitis, chronic pancreatitis, and pancreatic cysts are associated with future development of PDAC.
“Preexisting conditions such as acute pancreatitis, chronic pancreatitis, and pancreatic cysts have been associated with the future development of PDAC179,196”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [179]
The “Other Risk Factors for Pancreatic Cancer—Chronic Pancreatitis” section reports an association between antecedent chronic pancreatitis and pancreatic cancer. The passages from our copy do not establish the claimed association for acute pancreatitis or pancreatic cysts. (LLM, conf=0.86)
Experimental — accuracy not yet measuredChronic pancreatitis, especially in those who develop diabetes with chronic pancreatitis, has the highest proportional risk of developing PDAC.
“For example, chronic pancreatitis especially those who develop diabetes with chronic pancreatitis have the highest proportional risk of developing PDAC.178,179”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [179]
The “Chronic Pancreatitis” section (page unavailable) reports an elevated relative risk of pancreatic cancer among patients with chronic pancreatitis. The “Diabetes” section (page unavailable) separately reports increased risk among patients with diabetes, but the paper does not establish that patients who develop diabetes with chronic pancreatitis have the highest proportional risk. (LLM, conf=0.85)
Experimental — accuracy not yet measuredStandard abdominal CTs for the general population are fraught with missed diagnosis with standard approaches to interpretation.
“Finally, standard abdominal CTs for the general population are fraught with missed diagnosis with standard approaches to interpretation,170”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [170]
The Descriptive Epidemiology section says that high-quality cross-sectional imaging may detect pancreatic changes, but it does not assess standard abdominal CT interpretation or missed diagnoses in the general population. Searches for CT, missed diagnoses, and imaging-based detection found no passage addressing the claim; page numbers were unavailable in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measuredSome subjects who undergo abdominal CT for abdominal pain and have no visible cancer eventually develop PDAC within the next few years.
“Although most scans do not show any signs of cancer visible to radiologists, some subjects eventually develop PDAC in the next few years.170”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [170]
The Chronic Pancreatitis section discusses pancreatic-cancer risk, and the Diabetes section describes cancer diagnoses following new-onset diabetes, but neither addresses people whose abdominal CT scans showed no visible cancer. Searches for CT scans, radiologic visibility, abdominal pain, and later cancer diagnosis found no passage supporting that sequence or its timeframe. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThe pathogenesis is different for acute and chronic pancreatitis, but alcohol use has a significant impact on the pathophysiology of both and in the transition from acute to chronic pancreatitis.
“The pathogenesis is different for acute and chronic pancreatitis, but alcohol use has a significant impact on the pathophysiology of both 298, 299, 300, 301, 302 and in the transition from acute to chronic pancreatitis (see 303 ).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [300]
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Investigating the Pathobiology of Alcoholic Pancreatitis
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Chronic Pancreatitis in India and Asia
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Aspirin and Nonsteroidal Anti-inflammatory Drug Use and Risk of Pancreatic Cancer: A Meta-analysis
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Gestational diabetes as a risk factor for pancreatic cancer: a prospective cohort study
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Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case–control study
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Hospitalizations for Chronic Pancreatitis in Allegheny County, Pennsylvania, USA
Yadav, D. K., Muddana, V. N., & O’Connell, M. R. (2011) · Pancreatology · doi:10.1159/000331498 · Cited by 52 · see citing works
Self-citationSaligram, S., Lo, D. Y., Saul, M. I., & Yadav, D. K. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.03.025 · Cited by 52 · see citing works
Self-citationGestational diabetes and risk of incident primary cancer: a large historical cohort study in Israel
Sella, T., Chodick, G., Barchana, M., Heymann, A. D., Porath, A., Kokia, E. S., & Shalev, V. (2011) · Cancer Causes & Control · doi:10.1007/s10552-011-9825-5 · Cited by 46 · see citing works
Effect of type of alcoholic beverage in causing acute pancreatitis
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Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk
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Prevalence of fibrocalculous pancreatic diabetes in Chennai in South India.
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Aspirin use and pancreatic cancer risk
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Relationship of Serum Pancreatic Enzyme Testing Trends With the Diagnosis of Acute Pancreatitis
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Self-citationABO Blood Group and Chronic Pancreatitis Risk in the NAPS2 Cohort
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Recurrent Acute and Chronic Pancreatitis in Two Brothers With Familial Chylomicronemia Syndrome
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- Authors
- Yadav, D., & Lowenfels, A. B.
- Affiliations
- University of Pittsburgh Medical Center (US)
- New York Medical College (US)
- Corresponding author
- Yadav, Dhiraj
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 144
- Issue
- 6
- Pages
- 1252-1261
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3662544
- OpenAlex
- W1977379410
- Cited by
- 1,974
- References
- 100
- Citations by year
- 2026: 103 · 2025: 135 · 2024: 132 · 2023: 170 · 2022: 183 · 2021: 185 · 2020: 210 · 2019: 181 · 2018: 175 · 2017: 163 · 2016: 117 · 2015: 114 · 2014: 85 · 2013: 17 · 2012: 1
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077906)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- acute pancreatitis, chronic pancreatitis, pancreatic cancer, epidemiology, gallstones, cholecystectomy, alcohol consumption, smoking, risk factors, non-O blood group, racial disparities, smoking cessation, alcohol abstinence, disease burden
- MeSH terms
- Adult, Age Factors, Aged, Alcohol Drinking, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Pancreatitis, Prognosis, Risk Factors, Sex Factors, Smoking, Time Factors, Incidence, Prevalence, Pancreatitis, Alcoholic, Risk Reduction Behavior, Racial Groups
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