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Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons
Abstract
BACKGROUND: There is increasing recognition that the use of certain medications contributes to falls in seniors. Our objective was to update a previously completed meta-analysis looking at the association of medication use and falling to include relevant drug classes and new studies that have been completed since a previous meta-analysis. METHODS: Studies were identified through a systematic search of English-language articles published from 1996 to 2007. We identified studies that were completed on patients older than 60 years, looking at the association between medication use and falling. Bayesian methods allowed us to combine the results of a previous meta-analysis with new information to estimate updated Bayesian odds ratios (ORs) and 95% credible intervals (95% CrIs) RESULTS: Of 11 118 identified articles, 22 met our inclusion criteria. Meta-analyses were completed on 9 unique drug classes, including 79 081 participants, with the following Bayesian unadjusted OR estimates: antihypertensive agents, OR, 1.24 (95% CrI, 1.01-1.50); diuretics, OR, 1.07 (95% CrI, 1.01-1.14); beta-blockers, OR, 1.01 (95% CrI, 0.86-1.17); sedatives and hypnotics, OR, 1.47 (95% CrI, 1.35-1.62); neuroleptics and antipsychotics, OR, 1.59 (95% CrI, 1.37-1.83); antidepressants, OR, 1.68 (95% CrI, 1.47-1.91); benzodiazepines, OR, 1.57 (95% CrI, 1.43-1.72); narcotics, OR, 0.96 (95% CrI, 0.78-1.18); and nonsteroidal anti-inflammatory drugs, OR, 1.21 (95% CrI, 1.01-1.44). The updated Bayesian adjusted OR estimates for diuretics, neuroleptics and antipsychotics, antidepressants, and benzodiazepines were 0.99 (95% CrI, 0.78-1.25), 1.39 (95% CrI, 0.94-2.00), 1.36 (95% CrI, 1.13-1.76), and 1.41 (95% CrI, 1.20-1.71), respectively. Stratification of studies had little effect on Bayesian OR estimates, with only small differences in the stratified ORs observed across population (for beta-blockers and neuroleptics and antipsychotics) and study type (for sedatives and hypnotics, benzodiazepines, and narcotics). An increased likelihood of falling was estimated for the use of sedatives and hypnotics, neuroleptics and antipsychotics, antidepressants, benzodiazepines, and nonsteroidal anti-inflammatory drugs in studies considered to have "good" medication and falls ascertainment. CONCLUSION: The use of sedatives and hypnotics, antidepressants, and benzodiazepines demonstrated a significant association with falls in elderly individuals.
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“Other studies (506-510) have found significant increases (OR=1.2-2.6) in the risk of fractures associated with AP.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [510]
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BackgroundBenzodiazepine Use among Older Adults with Chronic Obstructive Pulmonary Disease
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“In keeping with the latter, and consistently in meta-analyses and systematic reviews, the use of sedatives and hypnotics, antidepressants, and benzodiazepines has been shown to be significantly associated with falls in older individuals [63,64].”
ResultPerceived social isolation, social disconnectedness and falls: the mediating role of depression
Quach, L., & Burr, J. A. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1732294 · Cited by 58
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“…with falling, anticholinergic symptoms, delirium, cerebrovascular events, parkinsonism, and oversedation of geriatric patients (Ballard et al., 2006; Woolcott et al., 2009; Clegg and Young, 2011; Gillespie et al., 2012; Hovstadius et al., 2014; Palmer et al., 2015; Salahudeen et al., 2015).”
BackgroundPrescription and Nonprescription Sleep Product Use Among Older Adults in the United States
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“Several medication classes, many of which have central nervous system effects, have been associated with increased risk for falls and fractures [4].”
BackgroundEffects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults
Juraschek, S. P., Simpson, L. M., Davis, B. R., Beach, J. L., Ishak, A. M., & Mukamal, K. J. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13445 · Cited by 54
“Furthermore, several observational studies have demonstrated a relationship between β-blockers and falls(18) or fracture(41); although, observational studies are inconsistent.(19) Further research is needed to confirm a potential relationship between β-blockers and fall pathways.”
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Maust, D. T., Petzold, K., Strominger, J., Kim, H. M., & Bohnert, A. S. B. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.48557 · Cited by 47
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Geriatric Conditions in Heart Failure
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“For instance, they are known to hasten death due to increased risk of stroke and falls (Woolcott et al., 2009).”
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“In a recent metaanalysis, use of BZDs was associated with a 40 % increased risk of falls in older individuals [21].”
BackgroundResultInfluentialDionne, P.-A., Vasiliadis, H., Latimer, E. A., Berbiche, D., & Préville, M. (2012) · Psychiatric Services · doi:10.1176/appi.ps.201200089 · Cited by 51
Bobo, W. V., & Shelton, R. C. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.143 · Cited by 50
Predicting Falls in Long-term Care Facilities: Machine Learning Study
Thapa, R., Garikipati, A., Shokouhi, S., Hurtado, M., Barnes, G., Hoffman, J. L., Calvert, J. S., Katzmann, L., Mao, Q., & Das, R. (2022) · JMIR Aging · doi:10.2196/35373 · Cited by 49
“Medications included benzodiazepines [9,34], antiepileptics [35], angiotensin-converting enzyme inhibitors [32], antidepressants [9], antipsychotics [36], narcotics [37], diuretics [36,38], β-blockers [39], antihistamines [33], neuromuscular blocking agents [40], calcium channel blockers [32], antiarrhythmics [41], se…”
BackgroundRisk factors for osteoporosis and fractures in rheumatoid arthritis
Baker, R., Narla, R. R., Baker, J. F., & Wysham, K. D. (2022) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2022.101773 · Cited by 51
Hawkins, E. J., Malte, C. A., Imel, Z. E., Saxon, A. J., & Kivlahan, D. R. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.003 · Cited by 51
Intensive Care in Traumatic Brain Injury Including Multi-Modal Monitoring and Neuroprotection
Stocker, R. A. (2019) · Medical Sciences · doi:10.3390/medsci7030037 · Cited by 60
Izza, M. A. D., Lunt, E., Gordon, A. L., Gladman, J. R. F., Armstrong, S., & Logan, P. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00376-1 · Cited by 48
NOFSA Guideline for the Diagnosis and Management of Osteoporosis
Hough, S. F., Ascott-Evans, B. H., Brown, S. L., Cassim, B., de Villiers, T. J., Lipschitz, S., Pettifor, J. M., & Sonnendecker, E. W. W. (2010) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2010.10872239 · Cited by 48
Mott, D. A., Martin, B. A., Breslow, R. M., Michaels, B., Kirchner, J., Mahoney, J., & Margolis, A. R. (2016) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2015.11.001 · Cited by 48
Drug-related mortality among inpatients: a retrospective observational study
Pardo-Cabello, A. J., Gavilán, E. D. P., Jiménez, F. J. G., Rodríguez, C. M., Luna, J. D. D., & Cañas, E. P. (2016) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2026-0 · Cited by 48
“from falls at home in elderly patients receiving psychotropic or antihypertensive drugs [31], causing their admission to the emergency department (Supplementary Material 1).”
BackgroundMin, Y., Nadpara, P. A., & Slattum, P. W. (2016) · Journal of Aging Research · doi:10.1155/2016/3685789 · Cited by 48
Thai Osteoporosis Foundation (TOPF) position statements on management of osteoporosis
Songpatanasilp, T., Sritara, C., Kitisomprayoonkul, W., Chaiumnuay, S., Nimitphong, H., Charatcharoenwitthaya, N., Pongchaiyakul, C., Namwongphrom, S., Kitumnuaypong, T., Srikam, W., et al. (2016) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2016.10.002 · Cited by 50
“Special precautions are needed for sedatives, hypnotics, anti-depressants and benzodiazepine [80].”
BackgroundKahlaee, H. R., Latt, M. D., & Schneider, C. R. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx189 · Cited by 48
Frailty Syndrome: Nursing Interventions
Uchmanowicz, I., Jankowska‐Polańska, B., Wleklik, M., Lisiak, M., & Gobbens, R. J. J. (2018) · SAGE Open Nursing · doi:10.1177/2377960818759449 · Cited by 53
“Drugs typically associated with risk of falls include diuretics, hypotensives, antiarrhythmics, antidiabetics, antidepressants, and central nervous system agents (Woolcott et al., 2009).”
BackgroundLukačišinová, A., Reissigová, J., Hadžiabdić, M. O., Brkić, J., Okuyan, B., Volmer, D., Tadić, I., Modamio, P., Mariño, E. L., Tachkov, K., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04742-7 · Cited by 47
“Adverse drug events including number of geriatric syndromes such as falls, fractures, functional and cognitive decline, psychomotor sedation, orthos-tasis and delirium associated with use of BZDs are well known [10–12].”
BackgroundPréville, M., Bossé, C., Vasiliadis, H., Voyer, P., Laurier, C., Berbiche, D., Pérodeau, G., Grenier, S., Béland, S., Dionne, P.-A., et al. (2012) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980812000232 · Cited by 51
“…Cappeliez, Pérodeau, & Préville, 2005 ); moreover, they have been associated with falls, a risk of fractures, and hospitalizations in older adults (Bolton et al., 2008 ; Cumming, & Le Couteur, 2003 ; Grymonpre et al., 1988 ; Tamblyn et al., 1994 ; Wagner et al., 2004 ; Woolcott et al., 2009 ).”
BackgroundWong, A. K. W., Lord, S. R., Sturnieks, D. L., Delbaere, K., Trollor, J. N., & Close, J. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12205 · Cited by 49
Geriatric Conditions and Adverse Drug Reactions in Elderly Hospitalized Patients
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New loop diuretic prescriptions may be an acute risk factor for falls in the nursing home
Berry, S. D., Mittleman, M. A., Zhang, Y., Solomon, D. H., Lipsitz, L. A., Mostofsky, E., Goldense, D., & Kiel, D. P. (2012) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3256 · Cited by 45
A prospective study of the association between orthostatic hypotension and falls: definition matters
McDonald, C., Pearce, M. S., Kerr, S. R. J., & Newton, J. L. (2016) · Age and Ageing · doi:10.1093/ageing/afw227 · Cited by 46
“Previous studies examining the association between falls and anti-hypertensive medications have shown class-specific effects: for instance diuretics, but not beta-blockers and angiotensin converting enzyme inhibitors, have been associated with falls [29].”
BackgroundKimura, T., Ogura, F., Yamamoto, K., Uda, A., Nishioka, T., Kume, M., Makimoto, H., Yano, I., & Hirai, M. (2016) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12496 · Cited by 46
“The use of benzodiazepines has been reported to be associated with increased risks of falls and cognitive impairment in the elderly.(24,25) The results of this study and the Albanian study(15) suggested a high competency of STOPP criteria ver.”
ResultHam, A. C., van Dijk, S. C., Swart, K. M. A., Enneman, A. W., van der Zwaluw, N. L., Brouwer-Brolsma, E. M., van Schoor, N. M., Zillikens, M. C., Lips, P. T. A. M., de Groot, C. P. G. M., et al. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13328 · Cited by 46
Patterns of benzodiazepines use in primary care adults with anxiety disorders
Bernard, M.-M. T., Luc, M., Carrier, J., Fournier, L., Duhoux, A., Côté, É., Lessard, O., Gibeault, C., Bocti, C., & Roberge, P. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00688 · Cited by 54
Pharmacotherapeutic Management of Dementia Across Settings of Care
Rattinger, G. B., Burcu, M., Dutcher, S. K., Chhabra, P. T., Rosenberg, P. B., Simoni‐Wastila, L., Franey, C. S., Walker, L. D., & Zuckerman, I. H. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12210 · Cited by 45
Vozoris, N. T., & Leung, R. S. T. (2011) · SLEEP · doi:10.5665/sleep.1116 · Cited by 44
Benefits and risks of antihypertensive medications in the elderly
Butt, D. A., & Harvey, P. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12446 · Cited by 46
Vozoris, N. T. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835ed5d0 · Cited by 44
“Sedative medications, which are generally used to treat insomnia and whose use is on the rise [31], have been found to be associated with increased morbidity and mortality [32,33].”
Rubino, A., Sanon, M., Ganz, M. L., Simpson, A., Fenton, M. C., Verma, S., Hartry, A., Baker, R. A., Duffy, R. A., Gwin, K., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.3630 · Cited by 47
Zhou, S., Jia, B., Kong, J.-H., Zhang, X., Lei, L., Tao, Z., Ma, L., Xiang, Q., Zhou, Y. C., & Cui, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1044744 · Cited by 44
“(Woolcott et al., 2009) conducted a meta-analysis of the increased risk of falls among older individuals with nine kinds of drugs and found that the use of sedatives and hypnotics, antidepressants, and benzodiazepines was significantly associated with falls in this population.”
MethodResultEffect of Medications on Physical Function and Cognition in Nursing Home Residents with Dementia
Dutcher, S. K., Rattinger, G. B., LANGENBERG, P. W., Chhabra, P. T., Liu, X., Rosenberg, P. B., Leoutsakos, J., Simoni‐Wastila, L., Walker, L. D., Franey, C. S., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12838 · Cited by 46
Krebs, E. E., Paudel, M. L., Taylor, B. C., Bauer, D. C., Fink, H. A., Lane, N. E., & Ensrud, K. E. (2016) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3579-9 · Cited by 44
“Our findings are consistent with those of a meta-analysis of medication use and falling in adults over the age of 60.(13) Opioids are thought to increase the risk of fracture either by increasing the likelihood of falling or by increasing the risk of fracture when falling occurs, most likely through adverse central ne…”
BackgroundResultEconomic Evaluation of Sedative Deprescribing in Older Adults by Community Pharmacists
Turner, J. P., Sanyal, C., Martin, P., & Tannenbaum, C. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa180 · Cited by 44
Inclusion of medication-related fall risk in fall risk assessment tool in geriatric care units
Michalcova, J., Vašut, K., Airaksinen, M., & Bielaková, K. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01845-9 · Cited by 44
Payne, R., Abel, G., Simpson, C., & Maxwell, S. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0058-z · Cited by 34
“[17] of 22 observational studies published between 1996 and 2007 found similar results, with psychotropic medicines having a stronger association than cardiovascular medicines.”
ResultHawkins, E. J., Malte, C. A., Grossbard, J. R., & Saxon, A. J. (2015) · Pain Medicine · doi:10.1111/pme.12787 · Cited by 43
Torstensson, M., Hansen, A. H., Leth-Møller, K., Jørgensen, T. S. H., Sahlberg, M., Andersson, C., Nelveg-Kristensen, K. E., Ryg, J., Weeke, P. E., Torp-Pedersen, C. T., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009522 · Cited by 43
“15 All studies included in the two meta-analyses are observational studies and are heterogeneous concerning study methods, settings, power and fall de fi nition.”
BackgroundWilleboordse, F., Schellevis, F., Chau, S. H., Hugtenburg, J. G., & Elders, P. J. M. (2017) · Family Practice · doi:10.1093/fampra/cmx007 · Cited by 43
“Patients were included if they scored ≥5 on the VAS scales (range 1–10) of the geriatric problems or reported ≥1 fall in the preceding 6 months.”
MethodInfluentialAre there guidelines for the responsible prescription of benzodiazepines?
el-Guebaly, N., Sareen, J., & Stein, M. B. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501104 · Cited by 42
Pratt, N. L., Ramsay, E. N., Ellett, L. M. K., Nguyen, T. A., Barratt, J. D., & Roughead, E. E. (2014) · Drug Safety · doi:10.1007/s40264-014-0179-2 · Cited by 42
“Systematic reviews and meta-analyses of observational and randomized controlled trials have found significant associations between use of psychoactive medicines and falls [9, 35, 36].”
BackgroundInfluentialAn Introduction to the Fundamentals of Randomized Controlled Trials in Pharmacy Research
Houle, S. K. D. (2015) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v68i1.1422 · Cited by 42
Medication use and fall‐risk assessment for falls in an acute care hospital
Chiu, M., Lee, H.-D., Hwang, H., Wang, S., & Lin, M. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12359 · Cited by 42
The impact of falls in the elderly
Boyé, N. D. A., Lieshout, E. M. M. V., van Beeck, E. F., Hartholt, K. A., van der Cammen, T. J. M., & Patka, P. (2012) · Trauma · doi:10.1177/1460408612463145 · Cited by 43
“Approximately, 33% of persons over 65 years use so-called fall-risk-increasing drugs (FRIDs) such as cardiovascular and psychotropic drugs (Leipzig et al., 1999a, 1999b; Woolcott et al., 2009).”
BackgroundFactors influencing prescribing of fall-risk-increasing drugs to the elderly: A qualitative study
Bell, H. T., Steinsbekk, A., & Granås, A. G. (2015) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2015.1041829 · Cited by 43
“Woolcott JC, richardson kJ, Wiens MO, Patel B, Marin J, [6] khan kM, et al.”
BackgroundEffects of benzodiazepines on orthostatic blood pressure in older people
Rivasi, G., Kenny, R. A., Ungar, A., & Romero-Ortuno, R. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2019.10.032 · Cited by 41
Rasmussen, N. H., Dal, J., van den Bergh, J. P., de Vries, F., Jensen, M. H., & Vestergaard, P. (2020) · Current Drug Safety · doi:10.2174/1574886315666200908110058 · Cited by 42
Sjöberg, C., & Wallerstedt, S. M. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12412 · Cited by 40
“Normal healthy (1), mild systemic disease (2), severe systemic disease (3), severe systemic disease that is a constant threat to life (4), moribund (5).”
BackgroundAskari, M., Eslami, S., Scheffer, A. C., Medlock, S. K., de Rooij, S. E., van der Velde, N., & Abu–Hanna, A. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0110-z · Cited by 41
“A recent meta-analysis again confirmed a significant association between falls and the use of sedatives and hypnotics, especially benzodiazepines, and also antidepressants in older individuals [14].”
BackgroundMethodSerotonin-Norepinephrine Reuptake Inhibitor Antidepressants and the Risk of Falls in Older People
Gribbin, J., Hubbard, R., Gladman, J. R. F., Smith, C. L., & Lewis, S. (2011) · Drugs & Aging · doi:10.2165/11592860-000000000-00000 · Cited by 41
Psychotropic Drug Prescription and the Risk of Falls in Nursing Home Residents
Cox, C. A., van Jaarsveld, H. J., Houterman, S., van der Stegen, J. C. G. H., Wasylewicz, A. T. M., Grouls, R. J. E., & van der Linden, C. M. J. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.07.004 · Cited by 41
Older Adult Falls: Effective Approaches to Prevention
Dellinger, A. M. (2017) · Current Trauma Reports · doi:10.1007/s40719-017-0087-x · Cited by 40
“For example, in a meta-analysis of 22 studies, Woolcott et al. demonstrated an increased likelihood of falls among older adults taking several classes of drugs: sedatives and hypnotics, neuroleptics and antipsychotics, antidepressants, benzodiazepines, and NSAIDs [16].”
Falls-Related Drug Use and Risk of Falls Among Older Adults: A Study in a US Medicare Population
Musich, S. A., Wang, S. S., Ruiz, J., Hawkins, K., & Wicker, E. R. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0470-x · Cited by 41
Ikai, S., Uchida, H., Mizuno, Y., Tani, H., Nagaoka, M., Tsunoda, K., Mimura, M., & Suzuki, T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.015 · Cited by 41
“Introduction 1 2 A high incidence of falls has been reported in elderly patients who have been prescribed 3 psychotropic medications (Bloch et al., 2011; Hill and Wee, 2012; Woolcott et al., 2009).”
BackgroundTamiya, H., Yasunaga, H., Matusi, H., Fushimi, K., Ogawa, S., & Akishita, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129366 · Cited by 41
“In a meta-analysis of 22 studies, fall was significantly associated with use of sedatives and hypnotics, neuroleptics and antipsychotics, antidepressants, and benzodiazepines, but was not associated with narcotics [1].”
BackgroundFalls in older persons with intellectual disabilities: fall rate, circumstances and consequences
Smulders, E., Enkelaar, L., Weerdesteyn, V., Geurts, A. C. H., & Valk, H. M. J. V. S. L. (2012) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2012.01643.x · Cited by 41
Jackson, J. W., Schneeweiß, S., VanderWeele, T. J., & Blacker, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105376 · Cited by 42
Antihypertensive drugs and the risk of fall injuries: A systematic review and meta-analysis
Zang, G. (2013) · Journal of International Medical Research · doi:10.1177/0300060513497562 · Cited by 42
Inappropriate benzodiazepine use in elderly patients and its reduction
Tannenbaum, C. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140355 · Cited by 40
Falls, a fear of falling and related factors in older adults with complex chronic disease
Lee, J., Choi, M., & Kim, C. O. (2017) · Journal of Clinical Nursing · doi:10.1111/jocn.13995 · Cited by 41
de Torres, L. Á. P., Varas-Fabra, F., Rodríguez, V., Moral, R. R., Fernández, J. A., González-Lama, J., Pérula, C. J., Roldán, A. M., & Dios‐Guerra, C. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.03.035 · Cited by 40
“Some of these diseases have been also reported to be related with falls.52,53 In analyzing the results, the se of drugs (antidepressants, neuroleptic antipsychotics, and enzodiazepines) did not show a statistical relationship with alls, unlike the results of the meta-analysis by Woolcott et al.53 Older adults who take…”
ResultSingle-case experimental research designs.
Kazdin, A. E. (2015) · Methodological issues and strategies in clinical research (4th ed.). · doi:10.1037/14805-029 · Cited by 39
Characteristics of fall‐related traumatic brain injury in older adults
Teo, D. B. S., Wong, H. C., Yeo, A. W., Lai, Y. W., Choo, E. L., & Merchant, R. A. (2018) · Internal Medicine Journal · doi:10.1111/imj.13794 · Cited by 39
Medication and medical diagnosis as risk factors for falls in older hospitalized patients
Wedmann, F., Himmel, W., & Nau, R. (2019) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-019-02668-3 · Cited by 43
Loggia, G., Attoh-Mensah, E., Pothier, K., Morello, R., Lescure, P., Bocca, M., Marcelli, C., & Chavoix, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01659 · Cited by 39
Classification of falls in stroke rehabilitation – not all falls are the same
Hanger, H. C., Wills, K. L., & WILKINSON, T. J. (2013) · Clinical Rehabilitation · doi:10.1177/0269215513496801 · Cited by 39
Thaler, H. W., Sterke, S., & van der Cammen, T. J. M. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0512-1 · Cited by 39
Metadata
- Authors
- Woolcott, J. C.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Woolcott, John C.
- ORCID
- Woolcott, John C.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2009-11-01
- Volume
- 169
- Issue
- 21
- Pages
- 1952
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2094113973
- Cited by
- 1,326
- References
- 54
- Citations by year
- 2026: 42 · 2025: 42 · 2024: 67 · 2023: 57 · 2022: 70 · 2021: 116 · 2020: 93 · 2019: 122 · 2018: 107 · 2017: 99 · 2016: 80 · 2015: 89 · 2014: 83 · 2013: 83 · 2012: 71
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- falls in older adults, fall risk, antihypertensive drugs, diuretics, beta-blockers, sedative-hypnotic drugs, antidepressants, benzodiazepines, narcotics, nonsteroidal anti-inflammatory drugs, drug safety, fall prevention, geriatric pharmacology, polypharmacy
- MeSH terms
- Accidental Falls, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Antidepressive Agents, Bayes Theorem, Benzodiazepines, Cardiovascular Agents, Cross-Sectional Studies, Diuretics, Humans, Hypnotics and Sedatives, Narcotics, Risk Factors, Sensitivity and Specificity, Antipsychotic Agents, Odds Ratio, Case-Control Studies, Randomized Controlled Trials as Topic
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