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Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus: Four-Year Results of the Look AHEAD Trial
Open accessAbstract
BACKGROUND: Lifestyle interventions produce short-term improvements in glycemia and cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no long-term data are available. We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study. METHODS: The Look AHEAD (Action for Health in Diabetes) trial is a multicenter randomized clinical trial comparing the effects of an intensive lifestyle intervention (ILI) and diabetes support and education (DSE; the control group) on the incidence of major CVD events in 5145 overweight or obese individuals (59.5% female; mean age, 58.7 years) with type 2 diabetes mellitus. More than 93% of participants provided outcomes data at each annual assessment. RESULTS: Averaged across 4 years, ILI participants had a greater percentage of weight loss than DSE participants (-6.15% vs -0.88%; P < .001) and greater improvements in treadmill fitness (12.74% vs 1.96%; P < .001), hemoglobin A(1c) level (-0.36% vs -0.09%; P < .001), systolic (-5.33 vs -2.97 mm Hg; P < .001) and diastolic (-2.92 vs -2.48 mm Hg; P = .01) blood pressure, and levels of high-density lipoprotein cholesterol (3.67 vs 1.97 mg/dL; P < .001) and triglycerides (-25.56 vs -19.75 mg/dL; P < .001). Reductions in low-density lipoprotein cholesterol levels were greater in DSE than ILI participants (-11.27 vs -12.84 mg/dL; P = .009) owing to greater use of medications to lower lipid levels in the DSE group. At 4 years, ILI participants maintained greater improvements than DSE participants in weight, fitness, hemoglobin A(1c) levels, systolic blood pressure, and high-density lipoprotein cholesterol levels. CONCLUSIONS: Intensive lifestyle intervention can produce sustained weight loss and improvements in fitness, glycemic control, and CVD risk factors in individuals with type 2 diabetes. Whether these differences in risk factors translate to reduction in CVD events will ultimately be addressed by the Look AHEAD trial. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00017953.
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“Evidence of T2D remission beyond two years is sparse, with examples in bariatric surgery and following the three lifestyle interventions: 1) meal replacements for caloric restriction and physical activity [5,7,8]; 2) short-term total diet replacement with rescue therapy for weight maintenance [9]; and 3) a calorie-restricted Mediterranean diet [10].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [8]
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“We previously reported improvements in glycemia, body weight, markers of liver disease and cardiovascular risk over two years among participants with T2D receiving a continuous care intervention (CCI) delivered via telemedicine by a care team who counseled participants on a very low carbohydrate diet including nutritional ketosis [8,19].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [8]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“the trajectory of outcomes in the usual care group followed for two years (showing no change in HbA1c and body weight concurrent with greater medication use [8])”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [8]
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“As comprehensive lifestyle treatment of overweight and obese adults with type 2 diabetes continues over 4 years, some weight regain will occur on average; partial weight regain is associated with an increase in hemoglobin A1c, but hemoglobin A1c remains below preintervention levels, and the reduction remains clinically meaningful.23”
From 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society (2014) · cites this paper as [23]
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“Structured weight loss programs with regular visits and use of meal replacements have been shown to enhance weight loss in people with diabetes (138 -140).”
From Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report (2019) · cites this paper as [140]
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“It is well recognized among professional society guidelines that carbohydrate restricted nutrition therapy results in improved glycemia, most cardiovascular risk markers and reduced need for medication [11][12][13][14], yet current evidence is limited to two-years of follow-up [8,15,16,17,18].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [8]
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“The slight increase in LDL-C encountered at one [19] and two years [8] (Fig. 2C) of the intervention regressed back to the baseline level at five years despite no significant changes in statin use, potentially reflecting the transient hypercholesterolemia associated with significant weight loss [31].”
From 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study (2024) · cites this paper as [8]
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“Structured weight loss programs with regular visits have been shown to enhance weight loss in T2DM [121,122,123].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [123]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C. D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035622 · Cited by 4,457
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439
(1998) · PubMed · Cited by 2,737
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1 of the 61 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [13]Trials of Hypertension Prevention Collaborative Research Group Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure: The Trials of Hypertension Prevention, Phase II Arch Intern Med 1997 157 657 667 1997 9080920
Cited by
Sorted by citations
Items 701–800 of 1,001
Weight Loss Interventions and Skeletal Health in Persons with Diabetes
Zhao, Q., Khedkar, S. V., & Johnson, K. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00744-9 · Cited by 12
Diabetes Prevention and the Role of Risk Factor Reduction in the Medicare Population
Koller, E. A., Chin, J. S., & Conway, P. H. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.12.019 · Cited by 11
Voils, C. I., Gierisch, J. M., Olsen, M. K., Maciejewski, M. L., Grubber, J. M., McVay, M. A., Strauss, J. L., Bolton, J., Gaillard, L. A., Strawbridge, E. M., et al. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.08.002 · Cited by 11
Long-Term Follow-Up of the Telemonitoring Weight-Reduction Program “Active Body Control”
Stumm, G., Blaik, A., Kropf, S., Westphal, S., Hantke, T. K., & Luley, C. H. (2016) · Journal of Diabetes Research · doi:10.1155/2016/3798729 · Cited by 13
International Models of Care that Address the Growing Diabetes Prevalence in Developing Countries
Singh, K., Ranjani, H., Rhodes, E., & Weber, M. B. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0768-9 · Cited by 11
eHealth and behavioral weight loss interventions for female cancer survivors: A review
Harvey, J. R., Dittus, K. L., & Mench, E. (2017) · Women s Health · doi:10.1177/1745505717731012 · Cited by 11
Kassim, M. A., Manaf, M. R. A., Nor, N. S. M., & Ambak, R. (2017) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2017.24.6.10 · Cited by 11
Optimizing lifestyle interventions in adult patients with comorbid asthma and obesity
Kuder, M. M., & Nyenhuis, S. M. (2020) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466620906323 · Cited by 14
A “Spoonful of Sugar” and the Realities of Diabetes Prevention!
Cefalu, W. T. (2014) · Diabetes Care · doi:10.2337/dc14-0181 · Cited by 11
Madjd, A., Taylor, M. A., Delavari, A., Malekzadeh, R., Macdonald, I. A., & Farshchi, H. R. (2019) · Obesity · doi:10.1002/oby.22416 · Cited by 10
“In the present study, the average percentage of weight loss during a 6-month intervention was similar to that of other behavioral lifestyle modification programs (32-34) and our previous study, which encompassed a similar dietary component and PA weekly duration (i.”
ResultKahn, R. (2012) · Health Affairs · doi:10.1377/hlthaff.2011.1075 · Cited by 10
Sonomtseren, S., Sankhuu, Y., Warfel, J. D., Johannsen, D. L., Peterson, C. M., & Vandanmagsar, B. (2016) · Obesity Science & Practice · doi:10.1002/osp4.56 · Cited by 10
Liakopoulos, V., Franzén, S., Svensson, J., Zethelius, B., Ottosson, J., Näslund, I., Guðbjörnsdóttir, S., & Eliasson, B. (2017) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2016-000386 · Cited by 11
Lee, C.-L., Liu, W.-J., & Wang, J. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.019 · Cited by 11
New Insights in the Prevention and Early Management of Type 2 Diabetes
Lau, D. C. W. (2011) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(11)53002-3 · Cited by 10
Charles, M., Simmons, R. K., Williams, K. M., Roglić, G., Sharp, S. J., Kinmonth, A., Wareham, N. J., & Griffin, S. J. (2012) · British Journal of General Practice · doi:10.3399/bjgp12x649070 · Cited by 10
Traina, S., Slee, A. E., Woo, S., & Canovatchel, W. J. (2015) · Diabetes Therapy · doi:10.1007/s13300-015-0145-8 · Cited by 10
Baptista, L. C. P., Machado‐Rodrigues, A. M., & Martins, R. A. (2018) · Biology of Sport · doi:10.5114/biolsport.2018.78057 · Cited by 11
Obesity Acceptance: Body Positivity and Clinical Risk Factors
McWhorter, K. L. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.93540 · Cited by 13
Obesity Primer for the Practicing Gastroenterologist
Jirapinyo, P., & Thompson, C. C. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001200 · Cited by 10
Zarrett, N. R., Wilson, D. K., Sweeney, A. M., Bell, B. A., Fairchild, A. J., Pinto, B. M., Miller, C., & Thames, T. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.106677 · Cited by 11
The level of health education in the Polish population.
Olszanecka‐Glinianowicz, M., & Chudek, J. T. (2013) · PubMed · Cited by 10
Effect of Workplace Weight Management on Health Care Expenditures and Quality of Life
Michaud, T. L., Nyman, J. A., Jutkowitz, E., Su, D., Dowd, B. E., & Abraham, J. M. (2016) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000864 · Cited by 10
PAULEY, M. E., Mays, C., Bailes, J., Schwartzman, M. L., Castle, M., McCoy, M., Patick, C., Preston, D. L., Nudelman, M. J. R., Denning, K. L., et al. (2021) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0078 · Cited by 12
Müller‐Wieland, D., Knebel, B., Haas, J., & Kotzka, J. (2012) · Herz · doi:10.1007/s00059-012-3608-y · Cited by 10
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763
Huang, C., Chuang, H., Chen, N.-C., Chen, S.-F., Hsu, C., & Chuang, Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153380 · Cited by 9
Physical inactivity and barriers to physical activity among Type-2 diabetics in Kumasi, Ghana
Taylor, L. K., Nyakotey, D. A., & Kwarteng, A. (2023) · African Health Sciences · doi:10.4314/ahs.v23i3.38 · Cited by 11
Chinese Guidelines for Medical Nutrition Therapy for Patients with Diabetes (2022 Edition).
(2024) · PubMed Central · doi:10.6133/apjcn.202406_33(2).0001 · Cited by 9
Li, D., Zou, H., Yin, P., Li, W., He, J., Wang, S., Huang, L., Shao, S., Chen, Y., Yang, Y., et al. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14217 · Cited by 11
Moon, R. C., & Almuwaqqat, Z. (2020) · Obesity · doi:10.1002/oby.22997 · Cited by 9
Preoperative weight loss in women with obesity in gynaecologic oncology: A retrospective study
Aubrey, C., Skeldon, M., Chapelsky, S., Giannakopoulos, N. V., Ghosh, S., Steed, H. L., & Pin, S. (2021) · Clinical Obesity · doi:10.1111/cob.12445 · Cited by 9
Corbin, K. D., IGUDESMAN, D. A., Addala, A., Casu, A., Crandell, J., Kosorok, M. R., Maahs, D. M., Pokaprakarn, T., Pratley, R. E., Souris, K. J., et al. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.106765 · Cited by 10
Neiberg, R. H., Rejeski, J., Applegate, W. B., Clark, J. M., Knowler, W. C., Bray, G. A., Espeland, M. A., & Cheskin, L. J. (2015) · Clinical Diabetes · doi:10.2337/diaclin.33.4.181 · Cited by 10
Largent, J. A., Vasey, J. J., Bessonova, L., Okerson, T. E., & Wong, N. D. (2013) · Advances in Therapy · doi:10.1007/s12325-013-0045-0 · Cited by 9
Methodological quality of behavioural weight loss studies: a systematic review
Lemon, S. C., Wang, M. L., Haughton, C. F., Estabrook, D. P., Frisard, C., & Pagoto, S. (2016) · Obesity Reviews · doi:10.1111/obr.12412 · Cited by 10
Effects of a self-management educational program on metabolic control in type 2 diabetes
Sadeghian, H. A., Madhu, S. V., Agrawal, K., KANNAN, A. T., & Agrawal, K. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1501-115 · Cited by 10
Sanguankeo, A., Lazo, M., Upala, S., Brancati, F. L., Bonekamp, S., Pownall, H. J., Balasubramanyam, A., Clark, J. M., & Fatty Liver Subgroup of the Look AHEAD Research Group (2016) · Endocrine Research · doi:10.1080/07435800.2016.1194856 · Cited by 9
Kalkan, A., Bodegård, J., Sundström, J., Svennblad, B., Östgren, C. J., Nilsson, P. N., Johansson, G., & Ekman, M. (2016) · Primary care diabetes · doi:10.1016/j.pcd.2016.11.002 · Cited by 9
Molema, C. C. M., Veldwijk, J., Wendel‐Vos, W., de Wit, G. A., van de Goor, I., & Schuit, A. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219112 · Cited by 9
Steffen, L. M., Yi, S.-Y. Y., Duprez, D. A., Zhou, X., Shikany, J. M., & Jacobs, D. R. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.09.001 · Cited by 9
Qin, Y., Chen, Y., Zhang, Z., Huang, S., Jiao, C., Zhang, Z., & Mao, L. (2021) · Obesity · doi:10.1002/oby.23238 · Cited by 9
Long-Term, Sustained, Lifestyle-Induced Weight Loss in Severe Obesity: the Get-Real Program
Shadid, S., Jakob, R. C., & Jensen, M. D. (2015) · Endocrine Practice · doi:10.4158/ep14381.or · Cited by 8
Cardiometabolic Risk Factor Response to a Lifestyle Intervention: A Randomized Trial
Harrington, D. M., Champagne, C. M., Broyles, S. T., Johnson, W. D., Tudor-Locke, C. E., & Katzmarzyk, P. T. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0112 · Cited by 9
Annuzzi, G., Rivellese, A. A., Bozzetto, L., & Riccardi, G. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.12.001 · Cited by 9
Tur, J. J., Alos, M., Iglésias, L., Luque, L., Colom, A., Escudero, A., Martínez, D., Pomar, A. P., Ugarriza, E., Frontera, M., et al. (2011) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2011.04.003 · Cited by 9
Martínez, J. J. G. (2011) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2011.09.007 · Cited by 10
Impact of Education on Weight in Newly Diagnosed Type 2 Diabetes: Every Little Bit Helps
Azar, K. M. J., Chung, S., Wang, E. J., Zhao, B., Linde, R. B., Lederer, J. R., & Palaniappan, L. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129348 · Cited by 9
Stoutenberg, M., Falcon, A. L., Arheart, K. L., Stasi, S., Portacio, F., Stepanenko, B. A., Lan, M. L., Castruccio-Prince, C., & Nackenson, J. (2016) · Health Education & Behavior · doi:10.1177/1090198116668827 · Cited by 9
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Weitgasser, R., & Niebauer, J. (2012) · Wiener klinische Wochenschrift · doi:10.1007/s00508-012-0275-1 · Cited by 9
Obesity and psychosocial well‐being among cancer patients and survivors
Philip, E. J., Bergerot, C. D., Clark, K. L., Bergerot, P. G., & Loscalzo, M. J. (2019) · Psycho-Oncology · doi:10.1002/pon.5181 · Cited by 9
Fujihara, K., KHIN, L. M., Murai, K., Yamazaki, Y., Tsuruoka, K., Yagyuda, N., Yamazaki, K., Maegawa, H., Tanaka, S., Kodama, S., et al. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15206 · Cited by 9
Palmer, R., Neiberg, R. H., Beavers, K. M., Kahn, S. E., Houston, D. K., Wagenknecht, L. E., Johnson, K., Pownall, H. J., Espeland, M. A., & For the Action for Health in Diabetes (Look AHEAD) Aging Study Group (2025) · Obesity · doi:10.1002/oby.24242 · Cited by 9
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Hall, M. E., Wang, Z., do Carmo, J. M., Kamimura, D., & Hall, J. E. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-59918-2_42 · Cited by 8
Addo, S. A., Nti, C., Vuvor, F., Adjimani, J. P., & Steiner‐Asiedu, M. (2019) · Journal of Nutrition and Metabolism · doi:10.1155/2019/4729040 · Cited by 8
Ashby‐Thompson, M., Heshka, S., Anderson, A., Pownall, H. J., Laferrère, B., Balasubramanyam, A., Heymsfield, S. B., Wadden, T. A., & Gallagher, D. (2024) · Obesity · doi:10.1002/oby.24025 · Cited by 8
Ewers, B., Blond, M. B., Bruun, J. M., & Vilsbøll, T. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00307-0 · Cited by 9
Diabetic Foot Ulcer Beyond Wound Closure: Clinical Practice Guideline
Wendland, D. M., Altenburger, E. A., Swen, S. B., & Haan, J. (2024) · Physical Therapy · doi:10.1093/ptj/pzae171 · Cited by 11
Liss, D. T., Finch, E. A., Gregory, D. L., Cooper, A., & Ackermann, R. T. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.11.016 · Cited by 8
Dandanell, S., Elbe, A., Pfister, G. U., Elsborg, P., & Helge, J. W. (2016) · Scandinavian Journal of Public Health · doi:10.1177/1403494816682378 · Cited by 8
Dintsios, C., Chernyak, N., Grehl, B., & Icks, A. (2018) · Systematic Reviews · doi:10.1186/s13643-018-0884-5 · Cited by 8
Karkare, S. U., Fridman, M., Dang‐Tan, T., Lu, J., Smolarz, B. G., DeKoven, M., & Iyer, N. N. (2019) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2019.18321 · Cited by 10
Wyst, K. B. V., Olson, M. L., Keller, C. S., Soltero, E. G., Williams, A. N., Peña, A., Ayers, S. L., Jager, J., & Shaibi, G. Q. (2020) · Pediatric Obesity · doi:10.1111/ijpo.12620 · Cited by 11
The older, the less potential benefit for type 2 diabetes from weight control
Zhou, Q., Sun, J., Wu, Z., Wu, W., Zhang, X., Pan, Q., Qi, H., Yuan, H., Shi, H., Cao, S., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02979-8 · Cited by 8
Pragmatic implementation of a fully automated online obesity treatment in primary care
Thomas, J. G., Panza, E. A., Espel‐Huynh, H., Goldstein, C. M., O’Leary, K. C., Benedict, N., Puerini, A. J., & Wing, R. R. (2022) · Obesity · doi:10.1002/oby.23502 · Cited by 9
Terapia Nutricional no Pré-Diabetes e no Diabetes Mellitus Tipo 2
Ramos, S., Campos, L. F., Baptista, D. R., Strufaldi, M. B., Gomes, D. L., Guimarães, D. B., Souto, D. L., Marques, M., Sousa, S. S. D. S., & de Campos, T. F. (2022) · Conectando Pessoas eBooks · doi:10.29327/557753.2022-25 · Cited by 10
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The Obesity Paradox and Diabetes
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Body Mass Index–Mortality Relationship in Severe Hypoglycemic Patients With Type 2 Diabetes
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Savory, L. A., Griffin, S. J., Williams, K. M., Prevost, A. T., Kinmonth, A. L., Wareham, N. J., & Simmons, R. K. (2013) · Diabetic Medicine · doi:10.1111/dme.12316 · Cited by 8
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Jakicic, J. M., Sox, H. C., Blair, S. N., Bensink, M. E., Johnson, W. G., King, A. C., Lee, I.-M. M., Nahum-Shani, I. B., Sallis, J. F., Sallis, R. E., et al. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000590 · Cited by 8
Zamri, L. A., Appannah, G., Zahari-Sham, S. Y., Mansor, F., Nor, N. S. M., Ambak, R., Samad, A. A., Dahlan, N. Y., & Aris, T. (2018) · BMC Women s Health · doi:10.1186/s12905-018-0593-1 · Cited by 8
Dutton, G. R., Lewis, C. E., Cherrington, A., Pisu, M., Richman, J., Turner, T., & Phillips, J. M. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.07.015 · Cited by 9
Muñoz-Torres, A. V., Medina‐Bravo, P., Valerio-Pérez, B. E., Salmerón, G. M., Escobedo, J., & López, L. V. (2020) · BMC Public Health · doi:10.1186/s12889-020-08866-4 · Cited by 8
O’Connell, J., Reid, M., Rockell, J., Harty, K., Perraillon, M. C., & Manson, S. M. (2021) · Medical Care · doi:10.1097/mlr.0000000000001521 · Cited by 8
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Bray, G. A. (2012) · JAMA · doi:10.1001/jama.2012.7263 · Cited by 8
N-3 Fatty Acids for Hypertriglyceridemia in Patients Taking Second-Generation Antipsychotics
Fetter, J. C., Brunette, M., & Green, A. I. (2013) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.febr.012513 · Cited by 7
Luca, S. A., Bungau, R. M., Lazăr, S., Potre, O., & Timar, B. (2024) · Medicina · doi:10.3390/medicina60020334 · Cited by 9
Weber, M. B., Rhodes, E., Ranjani, H., Jeemon, P., Ali, M. K., Hennink, M. M., Anjana, R. M., Mohan, V., Narayan, K. M. V., & Prabhakaran, D. (2023) · Implementation Science Communications · doi:10.1186/s43058-023-00516-1 · Cited by 7
The Academy of Nutrition and Dietetics National Coverage Determination Formal Request
Gradwell, E., & Raman, P. R. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jada.2011.10.018 · Cited by 7
Impact of Behavioral Interventions in the Management of Adults with Type 2 Diabetes Mellitus
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Ofori, S., & Kotseva, K. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0006-4 · Cited by 7
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Ryan, D. H. (2012) · Diabetes Care · doi:10.2337/dc12-0729 · Cited by 7
Employer-Funded Complete Health Improvement Program: Preliminary Results of Biomarker Changes
Remy, C., Shubrook, J. H., Nakazawa, M., & Drozek, D. S. (2017) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2017.054 · Cited by 7
Roux, S. B., Forde, L., MacNaughton, S., Shearer, R., Lindsay, R. S., Sattar, N. A., Morrison, D. S., Welsh, P. I., & Logue, J. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13171 · Cited by 7
Berkowitz, S. A., Chang, Y., Porneala, B., CROMER, S. J., Wexler, D. J., & Delahanty, L. M. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001514 · Cited by 7
Jiang, L., Xu, S., Mancuso, N., Newcombe, P. J., & Conti, D. V. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa287 · Cited by 7
Treatment of obesity and disability in schizophrenia.
Strassnig, M., & Harvey, P. D. (2013) · Europe PMC (PubMed Central) · Cited by 7
Aberle, J., Lautenbach, A., Meyhöfer, S., Meyhöfer, S. M., Selig, L., Blüher, M., & Menzen, M. (2021) · Diabetologie und Stoffwechsel · doi:10.1055/a-1515-8779 · Cited by 7
Muntis, F. R., IGUDESMAN, D. A., Sarteau, A. C., Thomas, J. M., Arrizon‐Ruiz, N., Hooper, J., Addala, A., Crandell, J., Riddell, M. C., Maahs, D. M., et al. (2022) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2022.0253 · Cited by 8
Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia
Alshaikh, A., Al-Jedai, A. H., Alfadda, A. A., Al-Robayan, A. A., Bawahab, A., Abo’ouf, S., Sultan, A., Alhozali, A. M., Bawazeer, M. A., Sheshah, E., et al. (2022) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2022.1312045 · Cited by 8
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Santos, A. L., & Sinha, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_15 · Cited by 8
Impact of weight loss on ankle‐brachial index and interartery blood pressures
Espeland, M. A., Lewis, C. E., Bahnson, J. L., Knowler, W. C., Regensteiner, J. G., Gaussoin, S. A., Beavers, D. P., & Johnson, K. (2013) · Obesity · doi:10.1002/oby.20658 · Cited by 7
de Vos, B. C., Runhaar, J., Verkleij, S. P., van Middelkoop, M., & Bierma‐Zeinstra, S. (2014) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.03.007 · Cited by 7
Giacco, R., Vetrani, C., Griffo, E., & Rivellese, A. A. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0063-1 · Cited by 7
Chen, T.-T., Tung, T.-H., Hsueh, Y.-S. A., Tsai, M.-H., Liang, H.-M., Li, K.-L., Chung, K., & Tang, C. (2015) · Value in Health · doi:10.1016/j.jval.2015.03.1793 · Cited by 7
Evaluation of an 18‐month commercial multidisciplinary obesity treatment programme
Aller, E. E. J. G., & van Baak, M. A. (2015) · Clinical Obesity · doi:10.1111/cob.12122 · Cited by 7
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Hamasaki, H. (2017) · InTech eBooks · doi:10.5772/64672 · Cited by 7
Swoboda, C. M., Miller, C. K., & Wills, C. E. (2017) · Clinical Diabetes · doi:10.2337/cd17-0023 · Cited by 7
Thomsen, C. F., Ried‐Larsen, M., Goetze, J. P., Andersen, L. B., Faber, J. O., Grøntved, A., & Jeppesen, J. (2019) · Peptides · doi:10.1016/j.peptides.2019.170156 · Cited by 7
Metadata
- Authors
- The Look AHEAD Research Group
- Affiliations
- Miriam Hospital (US)
- Corresponding author
- The Look AHEAD Research Group
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2010-09-27
- Volume
- 170
- Issue
- 17
- Pages
- 1566-75
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC3084497
- OpenAlex
- W1580839177
- Cited by
- 1,162
- References
- 61
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 31 · 2023: 38 · 2022: 37 · 2021: 54 · 2020: 75 · 2019: 66 · 2018: 84 · 2017: 96 · 2016: 90 · 2015: 83 · 2014: 102 · 2013: 146 · 2012: 113
- FWCI
- 84.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, U01DK057154, P30DK079637, U01DK057008, U01DK057171, DK57131, U01DK057219, U01DK056992, U01DK057177, P30DK017047, P30DK048520, DK 57151, P30-DK 48520)
- National Center for Research Resources (M01-RR-0021140, M01RR-00051, M01RR002719, M01RR000056, M01RR01346, M01RR000051, M01RR001066, M01RR001346, UL1RR024153, M0-1-RR-02719, M01-RR01066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- type 2 diabetes, intensive lifestyle intervention, weight loss, cardiovascular risk factors, glycemic control, HbA1c, blood pressure, HDL cholesterol, triglycerides, LDL cholesterol, diabetes support and education, Look AHEAD trial, long-term outcomes, overweight and obesity, cardiovascular disease prevention
- MeSH terms
- Aged, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Life Style, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Obesity, Patient Education as Topic, Physical Fitness, Risk Factors, Severity of Illness Index, Time Factors, Triglycerides, United States, Biomarkers, Weight Loss, Body Mass Index, Treatment Outcome, Diabetes Complications, Overweight
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