The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Magnitude of Acute Serum Creatinine Increase After Cardiac Surgery and the Risk of Chronic Kidney Disease, Progression of Kidney Disease, and Death
Open accessAbstract
BACKGROUND: Long-term outcomes after acute kidney injury remain poorly defined. We determined the association between the magnitude of creatinine increase after cardiac surgery and the risk of incident chronic kidney disease (CKD), CKD progression, and death. METHODS: We identified 29,388 individuals who underwent cardiac surgery at Veterans Affairs hospitals between November 1999 and September 2005. The magnitude of creatinine increase was defined by the percent change from baseline to peak creatinine levels after cardiac surgery and categorized as none (≤0%) or as class I, (1%-24%), II (25%-49%), III (50%-99%), or IV (≥100%). Cox proportional hazard models were used to examine the association between the magnitude of creatinine increase and outcomes. RESULTS: The relative hazards for outcomes increased monotonically with greater increases in creatinine levels compared with no change in creatinine levels. The relative hazards for adverse outcomes were significantly higher immediately after the creatinine increase and attenuated over time. Three months after surgery, creatinine increase classes I, II, III, and IV were associated with a greater risk of incident CKD (hazard ratios [HRs] 2.1, 4.0, 5.8, and 6.6, respectively; all P<.01), progression of CKD stage (HRs 2.5, 3.8, 4.4, and 8.0; all P<.01), and long-term mortality (HRs 1.4, 1.9, 2.8, and 5.0; all P<.01). At 5 years, the associations were lower in magnitude: incident CKD (HRs 1.4, 1.9, 2.3, and 2.3; all P<.01), CKD progression (HRs 1.5, 1.7, 1.7, and 2.4; all P<.01), and mortality (HRs 1.0, 1.2, 1.4, and 1.8; all P<.01, except class I). CONCLUSION: The magnitude of creatinine increase after cardiac surgery is associated in a graded manner with an increased risk of incident CKD, CKD progression, and mortality.
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Acute Kidney Injury Increases Risk of ESRD among Elderly
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Cited by
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Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus
Thakar, C. V., Christianson, A., Himmelfarb, J., & Leonard, A. C. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01120211 · Cited by 485
Hypoalbuminemia as Surrogate and Culprit of Infections
Wiedermann, C. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094496 · Cited by 394
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Sutherland, S. M., Chawla, L. S., Kane-Gill, S. L., Hsu, R. K., Kramer, A. A., Goldstein, S. L., Kellum, J. A., Ronco, C., Bagshaw, S. M., & on behalf of the 15 ADQI Consensus Group (2016) · Canadian Journal of Kidney Health and Disease · doi:10.1186/s40697-016-0099-4 · Cited by 115
Metadata
- Authors
- Ishani, A., Nelson, D., Clothier, B., Schult, T., Nugent, S., Greer, N., Slinin, Y., & Ensrud, K. E.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2011-02-14
- Volume
- 171
- Issue
- 3
- Pages
- 226
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2025627399
- Cited by
- 406
- References
- 27
- FWCI
- 20.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ishani, A., Nelson, D., Clothier, B., Schult, T., Nugent, S., Greer, N., Slinin, Y., & Ensrud, K. E. (2011). The Magnitude of Acute Serum Creatinine Increase After Cardiac Surgery and the Risk of Chronic Kidney Disease, Progression of Kidney Disease, and Death. Archives of Internal Medicine. https://doi.org/10.1001/archinternmed.2010.514
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
