Increasing US Rates of <emph type="ital" /> Endocarditis With <emph type="ital">Staphylococcus aureus</emph>: 1999-2008
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Estimates of the incidence and impact of bacterial infective endocarditis (IE) have been limited by the infrequency of the disease. Administrative data analyses can provide important information across a broad range of hospitals and regions. We used a recent, nationally representative sample to estimate the incidence of hospitalizations for bacterial IE in the United States.
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“Although the overall disease incidence has remained stable ranging annually from 3 to 7 per 100 000 person-years in the most contemporary population surveys (57-64), during the least years the epidemiology of IE has become more complex and the epidemiological profile has changed”
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“While this certainly affects the ability to generalize from our fi ndings, a recent cohort study (using the Nationwide Inpatient Sample) of more than 80,000 hospital discharges with a diagnosis of IE showed that the majority of cases also involved Caucasian (71%) males (60%), suggesting a similar trend in centers outs…”
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“The 3 most frequently identified organisms implicated in IE are staphylococcus, followed by streptococcus and enterococcus [4,5].”
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“burden of this disease is certainly increasing [16].”
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“Over the last decade, Staphylococcus aureus (SA) has emerged as the leading cause of infective endocarditis in the United States.1 Endocarditis due to SA has been associated with a high probability of mortality, emphasizing the importance of effective treatment options.”
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Management of MRSA/GISA, VISA Endocarditis
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Aerococcus urinae tricuspid valve infective endocarditis
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Microbiology of Infective Endocarditis and Microbiologic Diagnosis
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“Fiederspiel et al.22 recently reported nearly a 60% increased risk of in-hospital mortality from SAIE compared with streptococcal and enterococcal endocarditis.”
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Interventricular Septum Abscess
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“El 80% de los casos de endocarditis son producidos por estreptococo y estafilococo, pero este último es ahora en muchos centros el organismo causal más frecuente (1, 2), de acu erdo con lo que reportan Eusse y colaboradores.”
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- Authors
- Federspiel, J. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Federspiel, Jerome J.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2012-02-27
- Volume
- 172
- Issue
- 4
- Pages
- 363
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC3314241
- OpenAlex
- W1980888902
- Semantic Scholar
- 6464b63aa9b09c73bae7ce57feb62961d940e702
- Cited by
- 129
- References
- 9
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 14 · 2019: 10 · 2018: 18 · 2017: 10 · 2016: 14 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 2
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (0675027N)
- Pfizer
- GlaxoSmithKline
- Vertex Pharmaceuticals
- Medicines Company
- Astellas Pharma
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute on Aging (R01AG025801)
- National Heart, Lung, and Blood Institute (F30HL110483)
- National Institute of General Medical Sciences (T32GM008719)
- National Institute of Allergy and Infectious Diseases (K24AI093969, R01AI068804)
- Topics
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Keywords
- infective endocarditis, Staphylococcus aureus, bacterial endocarditis, incidence, hospitalization rates, administrative data, United States
- MeSH terms
- Endocarditis, Bacterial, Hospitalization, Humans, Retrospective Studies, Staphylococcus aureus, United States, Incidence, Logistic Models
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