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Cited by 743Cardiovascular Syncope and Autonomic DisordersVestibular and auditory disordersMedical Case Reports and Studies

A Neurological Syndrome Associated with Orthostatic Hypotension: A Clinical-Pathologic Study

SHY, G. MILTON·1960·A.M.A. Archives of Neurology
DOI 10.1001/archneur.1960.03840110025004
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Abstract

Introduction Perhaps, with the exception of adrenal insufficiency,1,2postural hypotension is coincident with involvement of the nervous system.3,4Many such cases are secondary to disorders like diabetes, syphilis, and other systemic diseases, which also affect the central or peripheral nervous system.4-12On exclusion of such disorders, however, one is left with an idiopathic orthostatic hypotension, which is almost invariably accompanied by clinical manifestation of nervous system involvement. Such patients may show wide swings in blood pressure, depending on body position, but do not have the pulse changes or symptoms, such as yawning, nausea, or increased sweating, associated with other types of syncope in which the nervous system is intact. The lesions of the nervous system present in a variety of ways, the commonest symptoms being loss of sweating, impotence, and, frequently, loss of sphincter control. Controversy exists as to whether the pathology of the nervous system is

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Crossref · 10.1001/archneur.1960.03840110025004

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  • Classic descriptions of Shy-Drager syndrome (now encompassed within multiple system atrophy) include constipation, gastroparesis, and, in severe cases, intestinal pseudo-obstruction.

    “Classic descriptions of Shy-Drager syndrome (now encompassed within multiple system atrophy, MSA) include constipation, gastroparesis, and, in severe cases, intestinal pseudo-obstruction (Shy et al., 1960).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Shy et al., 1960

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Authors
SHY, G. M.
Corresponding author
SHY, G. MILTON
Venue
A.M.A. Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1960-05-01
Volume
2
Issue
5
Pages
511
ISSN
0375-8540 (ISSN-L)
DOI
10.1001/archneur.1960.03840110025004
OpenAlex
W2146656698
Cited by
743
References
0
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 22 · 2020: 8 · 2019: 14 · 2018: 5 · 2017: 11 · 2016: 5 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 9
FWCI
10.99
Type
journal article
Language
en
Open access
closed
Locations
  • A M A Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
Keywords
orthostatic hypotension, neurological syndromes, idiopathic orthostatic hypotension, autonomic dysfunction, syncope, erectile dysfunction, blood pressure regulation
MeSH terms
Humans, Hypotension, Hypotension, Orthostatic, Neurologic Manifestations, Syndrome

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