Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Open accessAbstract
BACKGROUND: Idiopathic autonomic neuropathy is a severe, subacute disorder with a presumed autoimmune basis. It is indistinguishable from the subacute autonomic neuropathy that may accompany lung cancer or other tumors. Autoantibodies specific for nicotinic acetylcholine receptors in the autonomic ganglia are potentially pathogenic and may serve as serologic markers of various forms of autoimmune autonomic neuropathy. METHODS: We tested serum from 157 patients with a variety of types of dysautonomia. Immunoprecipitation assays with iodine-125-labeled epibatidine and solubilized human neuroblastoma acetylcholine receptors were used to detect autoantibodies that bound to or blocked ganglionic receptors. RESULTS: Ganglionic-receptor-binding antibodies were found in 19 of 46 patients with idiopathic or paraneoplastic autonomic neuropathy (41 percent), in 6 of 67 patients with postural tachycardia syndrome, idiopathic gastrointestinal dysmotility, or diabetic autonomic neuropathy (9 percent), and in none of 44 patients with other autonomic disorders. High levels of the binding antibodies correlated with more severe autonomic dysfunction (including the presence of tonic pupils). Levels of these antibodies decreased in patients who had clinical improvement. All seven patients with ganglionic-receptor-blocking antibodies had ganglionic-receptor-binding antibodies and had idiopathic or paraneoplastic autonomic neuropathy. CONCLUSIONS: Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptors identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia. The positive correlation between high levels of ganglionic-receptor antibodies and the severity of autonomic dysfunction suggests that the antibodies have a pathogenic role in these types of neuropathy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Seropositivity for antiganglionic acetylcholine receptor antibodies is the serological hallmark of autoimmune autonomic ganglionopathy.
“Seropositivity for antiganglionic acetylcholine receptor antibodies is the serological hallmark of autoimmune autonomic ganglionopathy.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [433]
Other antibodies, including ganglionic acetylcholine receptor antibodies and CRMP-5 (CV2), have also been associated with enteric dysmotility in paraneoplastic or autoimmune contexts.
“Other antibodies, including ganglionic acetylcholine receptor antibodies and CRMP-5 (CV2), have also been associated with enteric dysmotility in paraneoplastic/autoimmune contexts (Blackburn et al., 2019; Vernino et al., 2000), and neuropathologic studies show that some patients have more extensive involvement (Sodhi et al., 1989).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Vernino et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oosterhuis, H. (1997) · Cited by 2,404 · see citing works
Drachman, D. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302507 · Cited by 1,141 · see citing works
A Neurological Syndrome Associated with Orthostatic Hypotension: A Clinical-Pathologic Study
SHY, G. M. (1960) · A.M.A. Archives of Neurology · doi:10.1001/archneur.1960.03840110025004 · Cited by 743 · see citing works
Calcium-Channel Antibodies in the Lambert–Eaton Syndrome and Other Paraneoplastic Syndromes
Lennon, V. A., Kryzer, T. J., Griesmann, G. E., O’Suilleabhain, P. E., Windebank, A. J., Woppmann, A., Miljanich, G. P., & Lambert, E. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506013322203 · Cited by 595 · see citing works
Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548 · see citing works
Lucchinetti, C. F., Kimmel, D. W., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.3.652 · Cited by 499 · see citing works
Self-citationComposite Autonomic Scoring Scale for Laboratory Quantification of Generalized Autonomic Failure
Low, P. A. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60631-4 · Cited by 466 · see citing works
Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases
Yu, Z., & Lennon, V. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901213400311 · Cited by 431 · see citing works
Bradbury, S., & EGGLESTON, C. (1925) · American Heart Journal · doi:10.1016/s0002-8703(25)90007-5 · Cited by 373 · see citing works
Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia
Hart, I. K., Waters, C. T., Vincent, A. C., Newland, C., Beeson, D., Pongs, O., Morris, C. S., & Newsom–Davis, J. (1997) · Annals of Neurology · doi:10.1002/ana.410410215 · Cited by 314 · see citing works
Gerzanich, V., Peng, X.-D., Wang, F., Wells, G. B., Anand, R., Fletcher, S. R., & Lindstrom, J. M. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10533-6 · Cited by 290 · see citing works
Xu, W., Gelber, S. E., Orr‐Urtreger, A., Armstrong, D. L., Lewis, R. A., Ou, C., Patrick, J. W., Role, L. W., Biasi, M. D., & Beaudet, A. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5746 · Cited by 287 · see citing works
Low, P. A., Denq, J.-C., Opfer‐Gehrking, T. L., Dyck, P. J., O’Brien, P. C., & Slezak, J. M. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199712)20:12 · Cited by 277 · see citing works
Besinger, U. A., Toyka, K. V., Hömberg, M., Heininger, K., Hohlfeld, R., & Fateh-Moghadam, A. (1983) · Neurology · doi:10.1212/wnl.33.10.1316 · Cited by 277 · see citing works
Thermoregulatory Sweating Abnormalities in Diabetes Mellitus
Fealey, R. D., Low, P. A., & Thomas, J. E. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65338-5 · Cited by 274 · see citing works
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma
Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90593-a · Cited by 250 · see citing works
Self-citationHOWARD, F. M., Lennon, V. A., Finley, J., Matsumoto, J. Y., & Elveback, L. R. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb51321.x · Cited by 235 · see citing works
Vernino, S. A., Adamski, J., Kryzer, T. J., Fealey, R. D., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.6.1806 · Cited by 226 · see citing works
Autonomic Nervous System Function
Low, P. A. (1993) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199301000-00003 · Cited by 217 · see citing works
Postural Tachycardia Syndrome: Clinical Features and Follow-up Study
Sandroni, P., Opfer-Gehrking, T. L., McPhee, B. R., & Low, P. A. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.11.1106 · Cited by 194 · see citing works
Idiopathic autonomic neuropathy: Clinical, neurophysiologie, and follow‐up studies on 27 patients
Suarez, G. A., Fealey, R. D., Camilleri, M., & Low, P. A. (1994) · Neurology · doi:10.1212/wnl.44.9.1675 · Cited by 171 · see citing works
PURE PAN-DYSAUTONOMIA WITH RECOVERY
Young, R. R., Asbury, A. K., Corbett, J. L., & Adams, R. D. (1975) · Brain · doi:10.1093/brain/98.4.613 · Cited by 159 · see citing works
Serologic profile of myasthenia gravis and distinction from the Lambert-Eaton myasthenic syndrome
Lennon, V. A. (1997) · Neurology · doi:10.1212/wnl.48.suppl_5.23s · Cited by 111 · see citing works
Rust, G., Burgunder, J., Lauterburg, T., & Cachelin, A. B. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00290.x · Cited by 109 · see citing works
Myasthenia, thymoma, presynaptic antibodies, and a continuum of neuromuscular hyperexcitability
Vernino, S. A., Auger, R. G., Emslie‐Smith, A. M., Harper, C. M., & Lennon, V. A. (1999) · Neurology · doi:10.1212/wnl.53.6.1233 · Cited by 75 · see citing works
Camilleri, M., & Fealey, R. D. (1990) · Digestive Diseases and Sciences · doi:10.1007/bf01540409 · Cited by 73 · see citing works
Intestinal pseudo-obstruction, myasthenia gravis, and thymoma
Anderson, N. E., Hutchinson, D. O., Nicholson, G. I., Aitcheson, F., & Nixon, J. M. (1996) · Neurology · doi:10.1212/wnl.47.4.985 · Cited by 45 · see citing works
Calcium Channel and Related Paraneoplastic Disease Autoantibodies
Lennon, V. A. (1996) · Elsevier eBooks · doi:10.1016/b978-044482383-0/50022-4 · Cited by 39 · see citing works
Unusual Recovery From Acute Panautonomic Neuropathy After Immunoglobulin Therapy
Smit, A. A. J., Vermeulen, M., Koelman, J. H. T. M., & Wieling, W. (1997) · Mayo Clinic Proceedings · doi:10.4065/72.4.333 · Cited by 38 · see citing works
Malignant Thymoma With Dysautonomia and Disordered Neuromuscular Transmission
Tabbaa, M. A., Leshner, R. T., & Campbell, W. W. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520090079023 · Cited by 36 · see citing works
Postinfectious pandysautonomia with complete recovery after intravenous immunoglobulin therapy
Venkataraman, S., Alexander, M., & Gnanamuthu, C. P. (1998) · Neurology · doi:10.1212/wnl.51.6.1764 · Cited by 32 · see citing works
Nicotinic acetylcholine receptors in the neurones of autonomic ganglia
Skok, V. I. (1987) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(87)90012-9 · Cited by 13 · see citing works
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Khurana RK. Paraneoplastic autonomic dysfunction. In: Low PA, ed. Clinical autonomic disorders: evaluation and management. 2nd ed. Phila- delphia: Lippincott-Raven, 1997:545-54.
- Low PA, McLeod JG. Autonomic neuropathies. In: Low PA, ed. Clin- ical autonomic disorders: evaluation and management. 2nd ed. Philadel- phia: Lippincott-Raven, 1997:463-86.
- Griesmann GE, Lennon VA. Detection of autoantibodies in myasthe- nia gravis and Lambert-Eaton myasthenic syndrome. In: Rose NR, de Ma- cario EC, Folds JD, Lane HC, Nakamura RM, eds. Manual of clinical and laboratory immunology. 5th ed. Washington, D.C.: ASM Press, 1997:983- 8.
- Vernino S, Lennon VA. New Purkinje cell antibody (PCA-2): marker of lung cancer-related neurological autoimmunity. Ann Neurol 2000;47: 297-305.
Cited by
Sorted by citations
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951 · see citing works
Paraneoplastic Syndromes Involving the Nervous System
Darnell, R. B., & Posner, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023009 · Cited by 1,055 · see citing works
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
Blomström‐Lundqvist, C., Scheinman, M. M., Aliot, E., Alpert, J. S., Calkins, H. G., Camm, A. J., Campbell, W. B., Haines, D. E., Kück, K., Lerman, B. B., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.013 · Cited by 681 · see citing works
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516 · see citing works
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 474 · see citing works
Unravelling the pathogenesis of myasthenia gravis
Vincent, A. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri916 · Cited by 416 · see citing works
Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody
Thieben, M. J., Lennon, V. A., Boeve, B. F., Aksamit, A. J., Keegan, M. T., & Vernino, S. A. (2004) · Neurology · doi:10.1212/01.wnl.0000122648.19196.02 · Cited by 393 · see citing works
Neurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384 · see citing works
Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., Low, P. A., Park, S.-Y., Parkman, H. P., & Stanghellini, V. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0038-z · Cited by 411 · see citing works
Postural tachycardia syndrome (POTS)
LOW, P. A., SANDRONI, P., JOYNER, M., & SHEN, W. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01407.x · Cited by 358 · see citing works
Self-citationAutonomic Nervous System Dysfunction
Goldberger, J. J., Arora, R., Buckley, U., & Shivkumar, K. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.064 · Cited by 355 · see citing works
Muscle and neuronal nicotinic acetylcholine receptors
Kalamida, D., Poulas, K. A., Avramopoulou, V., Fostieri, E., Lagoumintzis, G., Lazaridis, K., Sideri, A., Zouridakis, M., & Tzartos, S. J. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05935.x · Cited by 334 · see citing works
Cardiac origins of the postural orthostatic tachycardia syndrome
Fu, Q., VanGundy, T. B., Galbreath, M. M., Shibata, S., Jain, M., Hastings, J. L., Bhella, P. S., & Levine, B. D. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.043 · Cited by 329 · see citing works
Inflammatory neuropathies of the enteric nervous system☆
GIORGIO, R. D., Guerrini, S., Barbara, G., Stanghellini, V., Ponti, F. D., Corinaldesi, R., Moses, P. L., Sharkey, K. A., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.024 · Cited by 303 · see citing works
Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis
Jain, S., & Goldstein, D. S. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.025 · Cited by 299 · see citing works
Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors
Graus, F., & Dalmau, J. O. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0194-4 · Cited by 278 · see citing works
Autonomic Nervous System Interaction With the Cardiovascular System During Exercise
Freeman, J. V., Dewey, F. E., Hadley, D., MYERS, J. N., & Froelicher, V. F. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.11.003 · Cited by 272 · see citing works
Kaufmann, H., Norcliffe‐Kaufmann, L., & Palma, J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1509723 · Cited by 271 · see citing works
Autonomic peripheral neuropathy
Freeman, R. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)74815-7 · Cited by 268 · see citing works
Postural tachycardia syndrome—current experience and concepts
Mathias, C. J., Low, D. A., Iodice, V., Owens, A. P., Kirbis, M., & Grahame, R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.187 · Cited by 251 · see citing works
Grubb, B. P. (2008) · Circulation · doi:10.1161/circulationaha.107.761643 · Cited by 224 · see citing works
Pediatric Disorders of Orthostatic Intolerance
Stewart, J. M., Boris, J. R., Chelimsky, G., Fischer, P. R., Fortunato, J. E., Grubb, B. P., Heyer, G. L., Jarjour, I. T., Medow, M. S., Numan, M. T., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-1673 · Cited by 222 · see citing works
Human enteric neuropathies: morphology and molecular pathology
GIORGIO, R. D., & Camilleri, M. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00538.x · Cited by 221 · see citing works
Paraneoplastic Syndromes Affecting the Nervous System
Darnell, R. B., & Posner, J. B. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.03.008 · Cited by 216 · see citing works
Gastrointestinal motility disorders in neurologic disease
Camilleri, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143771 · Cited by 211 · see citing works
Paraneoplastic isolated myelopathy
Flanagan, E. P., McKeon, A. B., Lennon, V. A., Kearns, J., Weinshenker, B. G., Krecke, K. N., Matiello, M., Keegan, B. M., Mokri, B., Aksamit, A. J., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821f468f · Cited by 213 · see citing works
The spectrum of autoimmune autonomic neuropathies
Klein, C. M., Vernino, S. A., Lennon, V. A., Sandroni, P., Fealey, R. D., Benrud‐Larson, L. M., Sletten, D. M., & Low, P. A. (2003) · Annals of Neurology · doi:10.1002/ana.10556 · Cited by 211 · see citing works
Neurocardiogenic Syncope and Related Disorders of Orthostatic Intolerance
Grubb, B. P. (2005) · Circulation · doi:10.1161/circulationaha.104.482018 · Cited by 210 · see citing works
Paraneoplastic Syndromes Affecting the Nervous System
Khasraw, M., & Khakoo, Y. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00101-3 · Cited by 203 · see citing works
Neurogenic Orthostatic Hypotension
Goldstein, D. S., & Sharabi, Y. (2009) · Circulation · doi:10.1161/circulationaha.108.805887 · Cited by 202 · see citing works
Autoantibody Profiles and Neurological Correlations of Thymoma
Vernino, S. A., & Lennon, V. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0735 · Cited by 200 · see citing works
Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer
Ost, D. E., Yeung, S. J., Tanoue, L. T., & Gould, M. K. (2013) · CHEST Journal · doi:10.1378/chest.12-2352 · Cited by 199 · see citing works
Autonomic Function Tests: Some Clinical Applications
Low, P. A., Tomalia, V. A., & Park, K. (2013) · Journal of Clinical Neurology · doi:10.3988/jcn.2013.9.1.1 · Cited by 191 · see citing works
Cheshire, W. P., Freeman, R. L., Gibbons, C. H., Cortelli, P., Wenning, G. K., Hilz, M. J., Spies, J. M., Lipp, A., Sandroni, P., Wada, N., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.11.024 · Cited by 195 · see citing works
Autoimmune Dementia: Clinical Course and Predictors of Immunotherapy Response
Flanagan, E. P., McKeon, A. B., Lennon, V. A., Boeve, B. F., Trenerry, M. R., Tan, K. M., Drubach, D. A., Josephs, K. A., Britton, J. W., Mandrekar, J. N., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0326 · Cited by 182 · see citing works
Nicotinic Acetylcholine Receptors of Muscles and Nerves
Lindstrom, J. M. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1254.007 · Cited by 176 · see citing works
Benarroch, E. E. (2007) · Neurology · doi:10.1212/01.wnl.0000281999.56102.b5 · Cited by 174 · see citing works
Inappropriate sinus tachycardia
Olshansky, B., & Sullivan, R. M. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.074 · Cited by 182 · see citing works
McKeon, A., Lennon, V. A., Lachance, D. H., Fealey, R. D., & Pittock, S. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.78 · Cited by 168 · see citing works
Self-citationPavlakis, P. P., Alexopoulos, H., Kosmidis, M. L., Mamali, I., Moutsopoulos, H. Μ., Tzioufas, A. G., & Dalakas, M. C. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.01.003 · Cited by 152 · see citing works
Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease
Lennon, V. A., Ermilov, L. G., Szurszewski, J. H., & Vernino, S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17429 · Cited by 178 · see citing works
The pathophysiology and diagnosis of orthostatic hypotension
Robertson, D. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-007-1004-0 · Cited by 154 · see citing works
Peripheral nervous system involvement in patients with cancer
Antoine, J.-C. G., & Camdessanché, J. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70679-2 · Cited by 134 · see citing works
Passive Transfer of Autoimmune Autonomic Neuropathy to Mice
Vernino, S. A., Ermilov, L. G., Sha, L., Szurszewski, J. H., Low, P. A., & Lennon, V. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1485-04.2004 · Cited by 133 · see citing works
Autonomic dysfunction in peripheral nerve disease
Low, P. A., Vernino, S. A., & Suárez, G. A. (2003) · Muscle & Nerve · doi:10.1002/mus.10333 · Cited by 134 · see citing works
Vernino, S. A., & Lennon, V. A. (2002) · Muscle & Nerve · doi:10.1002/mus.10266 · Cited by 131 · see citing works
New-onset Postural Orthostatic Tachycardia Syndrome Following Coronavirus Disease 2019 Infection
Kanjwal, K., Jamal, S. M., Kichloo, A., & Grubb, B. P. (2020) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2020.111102 · Cited by 129 · see citing works
Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease
Moses, P. L., Ellis, L. M., Anees, M. R., Ho, W., Rothstein, R. I., Meddings, J. B., Sharkey, K. A., & Mawe, G. M. (2003) · Gut · doi:10.1136/gut.52.5.629 · Cited by 127 · see citing works
Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy
Vernino, S., Hopkins, S., & Wang, Z. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.09.005 · Cited by 123 · see citing works
Self-citationMoscato, E. H., Jain, A., Peng, X., Hughes, E. G., Dalmau, J. O., & Balice‐Gordon, R. J. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07349.x · Cited by 120 · see citing works
Postural Orthostatic Tachycardia Syndrome: A Clinical Review
Johnson, J. N., Mack, K. J., Kuntz, N. L., Brands, C. K., Porter, C. J., & Fischer, P. R. (2010) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.07.002 · Cited by 119 · see citing works
Gunning, W. T., Kvale, H. M., Kramer, P. M., Karabin, B. L., & Grubb, B. P. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013602 · Cited by 118 · see citing works
Plasma Exchange for Primary Autoimmune Autonomic Failure
Schroeder, C., Vernino, S. A., Birkenfeld, A. L., Tank, J., Heusser, K., Lipp, A., Benter, T., Lindschau, C., Kettritz, R., Luft, F. C., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051719 · Cited by 118 · see citing works
Invited Article: Autonomic ganglia
Vernino, S. A., Sandroni, P., Singer, W., & Low, P. A. (2008) · Neurology · doi:10.1212/01.wnl.0000312280.44805.5d · Cited by 116 · see citing works
Pupil evaluation as a test for autonomic disorders
Bremner, F. (2009) · Clinical Autonomic Research · doi:10.1007/s10286-009-0515-2 · Cited by 116 · see citing works
New perspectives in the diagnosis and management of enteric neuropathies
Knowles, C. H., Lindberg, G., Panza, E., & GIORGIO, R. D. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.18 · Cited by 111 · see citing works
Serologic profiles aiding the diagnosis of autoimmune gastrointestinal dysmotility
Dhamija, R., Tan, K. M., Pittock, S. J., Foxx–Orenstein, A., Benarroch, E., & Lennon, V. A. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.04.009 · Cited by 114 · see citing works
Self-citationHemodynamic orthostatic dizziness/vertigo: Diagnostic criteria
Kim, H. A., Bisdorff, A., Bronstein, A. M., Lempert, T., Rossi-Izquierdo, M., Staab, J. P., Strupp, M. L., & Kim, J. (2019) · Journal of Vestibular Research · doi:10.3233/ves-190655 · Cited by 117 · see citing works
The osmopressor response to water drinking
May, M., & Jordan, J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00544.2010 · Cited by 113 · see citing works
Goldstein, D. S. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-010-0065-7 · Cited by 112 · see citing works
Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding
Vernino, S., & Stiles, L. E. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.005 · Cited by 107 · see citing works
Orthostatic hypotension: A review
Joseph, A., Wanono, R., Flamant, M., & Vidal‐Petiot, E. (2017) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2017.01.003 · Cited by 109 · see citing works
Autoimmune Channelopathies and Related Neurological Disorders
Vincent, A. C., Lang, B., & Kleopa, K. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.024 · Cited by 108 · see citing works
Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies
Singer, W., Spies, J. M., McArthur, J., Low, J., Griffin, J. W., Nickander, K. K., Gordon, V., & Low, P. A. (2004) · Neurology · doi:10.1212/01.wnl.0000110313.39239.82 · Cited by 105 · see citing works
The Postural Tachycardia Syndrome
Medow, M. S., & Stewart, J. M. (2007) · Cardiology in Review · doi:10.1097/01.crd.0000233768.68421.40 · Cited by 105 · see citing works
Kohr, D., Tschernatsch, M., Schmitz, K., Singh, P., Kaps, M., Schäfer, K., Diener, M., Mathies, J., Matz, O., Kummer, W., et al. (2009) · Pain · doi:10.1016/j.pain.2009.03.009 · Cited by 104 · see citing works
The Postural Orthostatic Tachycardia Syndrome:
Kanjwal, Y., KOSINSKI, D. J., & Grubb, B. P. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00262.x · Cited by 103 · see citing works
Demographics of a large paediatric Postural Orthostatic Tachycardia Syndrome Program
Boris, J. R., & Bernadzikowski, T. (2018) · Cardiology in the Young · doi:10.1017/s1047951117002888 · Cited by 100 · see citing works
BRADY, P. A., LOW, P. A., & SHEN, W. K. (2005) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2005.00227.x · Cited by 98 · see citing works
Idiopathic Autonomic Neuropathy
Sandroni, P., Vernino, S. A., Klein, C. M., Lennon, V. A., Benrud‐Larson, L. M., Sletten, D. M., & Low, P. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.1.44 · Cited by 100 · see citing works
Clinicopathological features of acute autonomic and sensory neuropathy
Koike, H., Atsuta, N., Adachi, H., Iijima, M., Katsuno, M., Yasuda, T., Fukada, Y., Yasui, K., Nakashima, K., Horiuchi, M., et al. (2010) · Brain · doi:10.1093/brain/awq214 · Cited by 96 · see citing works
Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome
Stewart, J. M., Medow, M. S., Glover, J. L., & Montgomery, L. D. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00784.2005 · Cited by 95 · see citing works
Pharmacotherapy for postural tachycardia syndrome
Miller, A. J., & Raj, S. R. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.008 · Cited by 91 · see citing works
Peripheral neuropathies in Sjogren syndrome: a new reappraisal
Pavlakis, P. P., Alexopoulos, H., Kosmidis, M. L., Stamboulis, E., Routsias, J. G., Tzartos, S. J., Tzioufas, A. G., Moutsopoulos, H. Μ., & Dalakas, M. C. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.222109 · Cited by 93 · see citing works
Postural Orthostatic Tachycardia Syndrome: Prevalence, Pathophysiology, and Management
Zadourian, A., Doherty, T. A., Swiatkiewicz, I., & Taub, P. R. (2018) · Drugs · doi:10.1007/s40265-018-0931-5 · Cited by 90 · see citing works
Iodice, V., Kimpinski, K., Vernino, S. A., Sandroni, P., Fealey, R. D., & Low, P. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92b52 · Cited by 91 · see citing works
Lang, P. M., Burgstahler, R., Sippel, W., Irnich, D., Schlotter‐Weigel, B., & Grafe, P. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00512.2003 · Cited by 91 · see citing works
Experimental Autoimmune Autonomic Neuropathy
Vernino, S. A., Low, P. A., & Lennon, V. A. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00408.2003 · Cited by 89 · see citing works
Neuropsychiatric manifestations in rheumatoid arthritis
Joaquim, A. F., & Appenzeller, S. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.07.015 · Cited by 89 · see citing works
Oldham, W. M., Lewis, G. D., Opotowsky, A. R., Waxman, A. B., & Systrom, D. M. (2016) · Pulmonary Circulation · doi:10.1086/685054 · Cited by 88 · see citing works
Wang, N., Orr‐Urtreger, A., & Korczyn, A. D. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00106-5 · Cited by 88 · see citing works
Disorders of the Autonomic Nervous System
Chelimsky, T. C., Robertson, D. M., & Chelimsky, G. G. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0434-1.00102-x · Cited by 87 · see citing works
Myasthenia gravis with autoimmune autonomic neuropathy
Vernino, S., Cheshire, W. P., & Lennon, V. A. (2001) · Autonomic Neuroscience · doi:10.1016/s1566-0702(01)00239-9 · Cited by 106 · see citing works
Autoimmune Gastrointestinal Dysmotility Treated Successfully With Pyridostigmine
Pasha, S. F., Lunsford, T. N., & Lennon, V. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.018 · Cited by 85 · see citing works
Adolescent Fatigue, POTS, and Recovery: A Guide for Clinicians
Kizilbash, S. J., Ahrens, S. P., Bruce, B. K., Chelimsky, G., Driscoll, S. W., Harbeck-Weber, C., Lloyd, R. M., Mack, K. J., Nelson, D. E., Ninis, N., et al. (2014) · Current Problems in Pediatric and Adolescent Health Care · doi:10.1016/j.cppeds.2013.12.014 · Cited by 120 · see citing works
Nakane, S., Higuchi, O., Koga, M., Kanda, T., Murata, K., Suzuki, T., Kurono, H., Kunimoto, M., Kaida, K., Mukaino, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118312 · Cited by 78 · see citing works
Koike, H., Watanabe, H., & Sobue, G. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302833 · Cited by 83 · see citing works
Combined Immunomodulatory Therapy in Autoimmune Autonomic Ganglionopathy
Gibbons, C. H., Vernino, S. A., & Freeman, R. L. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.60 · Cited by 83 · see citing works
Neural antigen‐specific autoimmune disorders
Iorio, R., & Lennon, V. A. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01144.x · Cited by 82 · see citing works
The Role of Intravitreal Corticosteroids in the Treatment of DME: Predictive OCT Biomarkers
Munk, M. R., Somfai, G. M., de Smet, M. D., Donati, G., Menke, M. N., Garweg, J. G., & Ćeklić, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147585 · Cited by 82 · see citing works
Achalasia: physiology and etiopathogenesis
Kraichely, R. E., & Farrugia, G. (2006) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2006.00569.x · Cited by 81 · see citing works
Characterization of ganglionic acetylcholine receptor autoantibodies
Vernino, S. A., Lindstrom, J. M., Hopkins, S., Wang, Z., & Low, P. A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.03.017 · Cited by 81 · see citing works
Paraneoplastic Dysmotility: Loss of Interstitial Cells of Cajal
Pardi, D. S., Miller, S., Miller, D., Burgart, L. J., Szurszewski, J. H., Lennon, V. A., & Farrugia, G. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05851.x · Cited by 77 · see citing works
The role of autoantibodies in the syndromes of orthostatic intolerance: a systematic review
Ruzieh, M., Batizy, L. H., Dasa, O., Oostra, C., & Grubb, B. P. (2017) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2017.1355068 · Cited by 74 · see citing works
A review of postural orthostatic tachycardia syndrome
Carew, S., ́Connor, M. O., Cooke, J., Conway, R. P., Sheehy, C. M., Costelloe, Á., & Lyons, D. (2008) · EP Europace · doi:10.1093/europace/eun324 · Cited by 73 · see citing works
Campanucci, V. A., Krishnaswamy, A., & Cooper, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.010 · Cited by 73 · see citing works
Flanagan, E. P., Saito, Y. A., Lennon, V. A., McKeon, A. B., Fealey, R. D., Szarka, L. A., Murray, J. A., Foxx–Orenstein, A. E., Fox, J. C., & Pittock, S. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12391 · Cited by 74 · see citing works
Autoimmune autonomic ganglionopathy
Wang, Z., Low, P. A., Jordan, J., Freeman, R. L., Gibbons, C. H., Schroeder, C., Sandroni, P., & Vernino, S. A. (2007) · Neurology · doi:10.1212/01.wnl.0000263185.30294.61 · Cited by 73 · see citing works
Neural Autoantibody Clusters Aid Diagnosis of Cancer
Horta, E. S., Lennon, V. A., Lachance, D. H., Jenkins, S. M., Smith, C. Y., McKeon, A. B., Klein, C. J., & Pittock, S. J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0652 · Cited by 72 · see citing works
- Authors
- Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A.
- Affiliations
- Mayo Clinic (US)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-09-21
- Volume
- 343
- Issue
- 12
- Pages
- 847-855
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341201500
- Cited by
- 674
- References
- 34
- Citations by year
- 2026: 16 · 2025: 10 · 2024: 33 · 2023: 20 · 2022: 26 · 2021: 36 · 2020: 28 · 2019: 30 · 2018: 32 · 2017: 24 · 2016: 21 · 2015: 21 · 2014: 19 · 2013: 31 · 2012: 27
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Keywords
- autoantibodies, postural orthostatic tachycardia syndrome, diabetic autonomic neuropathy, gastrointestinal motility disorders, autonomic dysfunction, serological markers, epibatidine, tonic pupil
- MeSH terms
- Adult, Aged, Autoantibodies, Autoimmune Diseases, Autonomic Nervous System Diseases, Diabetic Neuropathies, Female, Follow-Up Studies, Ganglia, Autonomic, Humans, Male, Middle Aged, Receptors, Nicotinic, Sensitivity and Specificity, Severity of Illness Index, Sweating, Paraneoplastic Syndromes, Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
