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Brain Peroxidase and Catalase in Parkinson Disease
Abstract
Peroxidase and catalase activities were determined in various regions of parkinsonian brains and control brains from patients with nonneurological diseases. The highest peroxidase activity was localized in the substantia nigra of the normal brain. In Parkinson disease, the peroxidase activity was decreased in the substantia nigra, caudate and putamen. Catalase activity was also reduced in the substantia nigra and putamen of the parkinsonian brain. These enzyme changes may be causally related to the degeneration and depigmentation of the substantia nigra neurons in Parkinson disease.
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Citations
Cited by
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Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383
Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346
Metadata
- Authors
- Ambani, L. M., Van Woert, M. H., & Murphy, S.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1975-02-01
- Volume
- 32
- Issue
- 2
- Pages
- 114-118
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2144102286
- Cited by
- 402
- References
- 0
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ambani, L. M., Van Woert, M. H., & Murphy, S. (1975). Brain Peroxidase and Catalase in Parkinson Disease. Archives of Neurology. https://doi.org/10.1001/archneur.1975.00490440064010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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