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Cited by 41Cerebrospinal fluid and hydrocephalusIon Transport and Channel RegulationElectrolyte and hormonal disorders

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The Sink Action of Cerebrospinal Fluid Volume Flow: Effect on Brain Water Content

Hochwald, Gerald M.·1976·Archives of Neurology
DOI 10.1001/archneur.1976.00500050025005
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Abstract

Effects of changes in serum osmolarity on volume flow of fluid into the cerebral ventricles of cats were measured by ventriculocisternal perfusion with mock cerebrospinal fluid (CSF), mock CSF containing acetazolamide, or a 30 mOsm/liter sucrose solution. Serum osmolarity was altered by intravenous infusion of a sucrose solution ranging between 10 and 650 mOsm/liter changing volume flow. For all perfusion fluids, regression lines relating volume flow to infused solution osmolarity were parallel. After infusion of a 10 mOsm/liter solution, brain water content increased. One hour after infusion, volume flow returned to normal, although serum was still hypotonic. Gray matter water content was still elevated; white matter returned to normal. The results suggest that the source of increased volume flow is the brain, and that the CSF acts as a sink, limiting excess water accumulation during water intoxication.

Overview

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Registry

Crossref · 10.1001/archneur.1976.00500050025005

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Hochwald, G. M.
Corresponding author
Hochwald, Gerald M.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1976-05-01
Volume
33
Issue
5
Pages
339
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1976.00500050025005
OpenAlex
W2134730195
Cited by
41
References
20
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2015: 1
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords
brain ventricles, serum osmolarity, water intoxication, brain water content, cerebral edema, acetazolamide, osmotic diuretics, ventriculocisternal perfusion, cats
MeSH terms
Animals, Blood, Body Water, Brain Chemistry, Cats, Cerebral Ventricles, Cerebrospinal Fluid, Cerebrovascular Circulation, Intracranial Pressure, Osmolar Concentration

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CoChat. (2026). Citation check: The Sink Action of Cerebrospinal Fluid Volume Flow: Effect on Brain Water Content. https://app.cochat.ai/papers/10.1001/archneur.1976.00500050025005
The paper
Hochwald, G. M. (1976). The Sink Action of Cerebrospinal Fluid Volume Flow: Effect on Brain Water Content. Archives of Neurology. https://doi.org/10.1001/archneur.1976.00500050025005

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.