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Bulk flow and diffusion in the cerebrospinal fluid system of the goat
Abstract
Ventriculocisternal perfusions were carried out on chronically prepared, unanesthetized goats. Measurements were made of steady-state rates at which inulin, fructose, creatinine, urea, K, Na, and labeled water (TOH) were removed from perfusion fluid at various hydrostatic and osmotic pressures. The ventricular system is virtually impermeable to inulin. Inulin is removed from subarachnoid spaces by bulk absorption at rates which vary linearly with hydrostatic pressure. Net absorption ceases at –15 cm H 2 O. Rate of net formation of cerebrospinal fluid (CSF) is equal to inulin clearance plus the difference between outflow and inflow rates; normally it averages 0.16 cm 3 min–1 and is essentially independent of hydrostatic pressures in the range –10 to +30 cm H 2 O. Net rate of formation is linearly related to total osmotic pressure differences between plasma and CSF. The coefficient of osmotic flow is greater than that measured from diffusion of TOH, as in other porous membranes. Passive permeability characteristics resemble those of the vasopressin-treated toad bladder.
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Cited by
A new look at cerebrospinal fluid circulation
Brinker, T., Stopa, E., Morrison, J., & Klinge, P. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-10 · Cited by 819
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
Hladky, S. B., & Barrand, M. A. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-26 · Cited by 633
Physiology of the choroid plexus.
Cserr, H. F. (1971) · Physiological Reviews · doi:10.1152/physrev.1971.51.2.273 · Cited by 514
Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain
Ma, Q., Ries, M., Decker, Y., Müller, A., Riner, C., Bücker, A., Fassbender, K., Detmar, M., & Proulx, S. T. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1916-x · Cited by 210
Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus
Lindvall, M., Edvinsson, L., & Owman, C. (1978) · Science · doi:10.1126/science.663649 · Cited by 195
Metadata
- Authors
- Heisey, S. R., Held, D., & Pappenheimer, J. R.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1962-11-01
- Volume
- 203
- Issue
- 5
- Pages
- 775-781
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2310995028
- Cited by
- 399
- References
- 0
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heisey, S. R., Held, D., & Pappenheimer, J. R. (1962). Bulk flow and diffusion in the cerebrospinal fluid system of the goat. American Journal of Physiology-Legacy Content. https://doi.org/10.1152/ajplegacy.1962.203.5.775
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