The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Clinical Correlates of White-Matter Changes on Magnetic Resonance Imaging Scans of the Brain
Abstract
We report our observations on the clinical and radiologic correlates of changes in cerebral white matter based on 94 subjects undergoing magnetic resonance imaging in a prospective study of dementia. Periventricular hyperintensity occurred twice as often in patients with Alzheimer's disease as in healthy control subjects. Within the control group, the presence of periventricular hyperintensity correlated significantly with one measure of cerebral atrophy and with the presence of changes in the adjoining deep white matter. The significance of white-matter changes distinct from the ventricles (leuko-araiosis) remains unsettled. Leuko-araiosis on the magnetic resonance imaging scan, unlike its correlate on the computed tomographic scan, was not shown to relate to cognitive decline or to the presence of focal abnormalities on neurologic examination. This is likely to reflect the heterogeneity of the changes detected with magnetic resonance imaging and their limited extent in our subjects.
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Awad, I. A., Johnson, P. C., Spetzler, R. F., & Hodak, J. A. (1986) · Stroke · doi:10.1161/01.str.17.6.1090 · Cited by 572
Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging
Rezek, D. L., Morris, J. C., Fulling, K. H., & Gado, M. H. (1987) · Neurology · doi:10.1212/wnl.37.8.1365 · Cited by 173
Cited by
The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.
Gunning-Dixon, F. M., & Raz, N. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.2.224 · Cited by 794
Neuroimaging studies of mood disorder effects on the brain
Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660
Pantoni, L., & Garcia, J. H. (1995) · Stroke · doi:10.1161/01.str.26.7.1293 · Cited by 538
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 489
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
Yoshita, M., Fletcher, E., Harvey, D., Ortega, M., Martinez, O., Mungas, D. M., Reed, B. R., & DeCarli, C. S. (2006) · Neurology · doi:10.1212/01.wnl.0000249119.95747.1f · Cited by 434
Metadata
- Authors
- Mirsen, T. R., Lee, D. H., Wong, C. J., Diaz, J. F., Fox, A. J., Hachinski, V. C., & Merskey, H.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1991-10-01
- Volume
- 48
- Issue
- 10
- Pages
- 1015-1021
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1993468227
- Cited by
- 188
- References
- 2
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical Correlates of White-Matter Changes on Magnetic Resonance Imaging Scans of the Brain. https://app.cochat.ai/papers/10.1001/archneur.1991.00530220031015
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- Mirsen, T. R., Lee, D. H., Wong, C. J., Diaz, J. F., Fox, A. J., Hachinski, V. C., & Merskey, H. (1991). Clinical Correlates of White-Matter Changes on Magnetic Resonance Imaging Scans of the Brain. Archives of Neurology. https://doi.org/10.1001/archneur.1991.00530220031015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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