Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging
Abstract
The significance of periventricular lucencies in the white matter on CT in demented patients is not understood. We studied the relationship of these changes to mental status of subjects with senile dementia of the Alzheimer type. A semiquantitative method showed more numerous and extensive lucencies in demented than in healthy elderly. Neuropathologic examination of five subjects with these changes and confirmed Alzheimer's disease revealed diffuse white matter pallor without infarction. There were no hypertensive vascular changes, although limited hyaline thickening was present.
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AD subjects show more pervasive white matter change.
“AD subjects show more pervasive white matter change [42–46].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [42]
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“WMH have been shown for some time to be greater in volume and severity in Alzheimer’s disease patients than in healthy elderly individuals (Rezek et al., 1987; Scheltens et al., 1992; Barber et al., 1999), and more recently, have been considered by some to be a core feature of”
BackgroundA Population‐Based Study on Motor Performance and White Matter Lesions in Older Women
Guo, X., Skoog, I. G., Matousek, M., Larsson, L., Palsson, S. P., Sundh, W., & Steen, B. C. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb06896.x · Cited by 36 · see citing works
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In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome
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Propionibacterium acnes in the cortex of patients with Alzheimer's disease
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Brain Imaging in Dementia of the Alzheimer Type
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Leukb‐Araiosis and Cerebral Hypoperfusion Compared in Elderly Normals and Alzheimer's Dementia
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“Leukoaraiosis has been found to reflect neuropathology (Janota et al. 1989) and this is bound to cause further confusion in differential diagnosis in the elderly where such lesions are common (Rezek et al. 1987).”
Background
- Authors
- Rezek, D. L., Morris, J. C., Fulling, K. H., & Gado, M. H.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Morris, John C.
- Venue
- Neurology
- Published
- 1987-08
- Volume
- 37
- Issue
- 8
- Pages
- 1365-1365
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2136432656
- Cited by
- 173
- References
- 0
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ns007205-32)
- National Institute on Aging (P01 AG0 3991, P01AG003991)
- National Institute of Neurological Disorders and Stroke (5 T32 NS07205-04)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- senile dementia of the Alzheimer type, Alzheimer's disease, normal aging, mental status, head CT, neuropathology
- MeSH terms
- Aged, Aging, Alzheimer Disease, Brain, Cerebral Ventricles, Female, Humans, Longitudinal Studies, Male, Tomography, X-Ray Computed
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