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Therapy for Neurocysticercosis: Comparison Between Albendazole and Praziquantel
Abstract
Praziquantel and albendazole have been recently described as effective drugs for treatment of intraparenchymal brain cysticercosis. We performed a prospective study comparing the efficacy of these drugs. Twenty-two patients were treated with praziquantel and 21 with albendazole. In addition, 16 patients were treated with symptomatic drugs only and used as controls. Treatment was discontinued in two patients receiving praziquantel and one patient receiving albendazole owing to acute decompensation of the increased intracranial pressure, and one of them died. Albendazole and praziquantel were effective when compared with the control group. However, albendazole was significantly more effective than praziquantel in reducing the total number of cysts in the computed tomographic scans (88% vs 50%). Despite these results, however, analysis of clinical course showed a high frequency of neurologic sequelae. Considering the risks and fallibility of anticysticercal therapy, the real solution for this serious disease continues to be prophylaxis of infestation.
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Cites
Neurocysticercosis: Short Course of Treatment With Albendazole
Alarcón, F. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520470099034 · Cited by 63
Cited by
García, H. H., Gonzalez, A. E., Evans, C. A., & Gilman, R. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14117-7 · Cited by 835
Current Consensus Guidelines for Treatment of Neurocysticercosis
García, H. H., Evans, C. A. W., Nash, T. E., Takayanagui, O. M., White, A. C., Botero, D., Rajshekhar, V., Tsang, V. C. W., Schantz, P. M., Allan, J. C., et al. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.4.747-756.2002 · Cited by 508
Self-citationUpdate on Eosinophilic Meningoencephalitis and Its Clinical Relevance
Graeff-Teixeira, C., da Silva, A. C. A., & Yoshimura, K. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00044-08 · Cited by 287
Nanoformulations of Albendazole As Effective Anticancer and Antiparasite Agents
Movahedi, F., Li, L., Gu, W., & Xu, Z. P. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0102 · Cited by 34
Metadata
- Authors
- Takayanagui, O. M.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1992-03-01
- Volume
- 49
- Issue
- 3
- Pages
- 290
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2015302256
- Cited by
- 190
- References
- 1
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Takayanagui, O. M. (1992). Therapy for Neurocysticercosis: Comparison Between Albendazole and Praziquantel. Archives of Neurology. https://doi.org/10.1001/archneur.1992.00530270106026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.