Nanoformulations of Albendazole As Effective Anticancer and Antiparasite Agents
Abstract
Initially emerging as a widely used clinical antiparasitic drug, albendazole (ABZ) has been increasingly recognized as an effective anticancer agent due to its outstanding advantage, in other words, low toxicity to normal cells but high effectiveness against parasites and some tumors. The major challenge is its poor water solubility and subsequently low bioavailability. This article thus first reviews the brief achievements in using ABZ to treat parasites and cancers, and summarizes the basic mechanisms of action of ABZ. Then this article critically reviews recent nanotechnological strategies, in other words, formulating/conjugating it with carriers into nanoformulations, in practices of improving aqueous solubility and efficacy in treatment of tumors and parasites. Our expert opinions in this field are provided for more effective delivery of ABZ to treat tumors and parasites in vivo.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The most successful approach to overcome low solubility of albendazole is to formulate or conjugate it into nanostructures or nanoformulations to improve aqueous solubility.
“Among various trials to overcome this problem, the most successful approach is to formulate or conjugate it into nanostructures or nanoformulations, in practice of improving aqueous solubility [358].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [358]
Cites
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108 · see citing works
Vascular endothelial growth factor (VEGF) inhibition—a critical review
Sousa Moreira, I., Alexandrino Fernandes, P., & Joao Ramos, M. (2007) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152007780058687 · Cited by 110 · see citing works
Ehteda, A., Galettis, P., Pillai, K., & Morris, D. L. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-86 · Cited by 44 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
Albendazole and Praziquantel: Review and Safety Monitoring in Korea
Hong, S.-T. (2018) · Infection & Chemotherapy · doi:10.3947/ic.2018.50.1.1 · Cited by 65 · see citing works
- Authors
- Movahedi, F., Li, L., Gu, W., & Xu, Z. P.
- Affiliations
- The University of Queensland (AU)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2017-09-28
- Volume
- 12
- Issue
- 20
- Pages
- 2555-2574
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2759307003
- Cited by
- 34
- References
- 3
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- albendazole, nanoformulations, anticancer agents, antiparasitic drugs, drug delivery, water solubility, bioavailability, drug carriers, drug conjugation, mechanism of action
- MeSH terms
- Animals, Antineoplastic Agents, Antiparasitic Agents, Biological Availability, Chemistry, Pharmaceutical, Drug Carriers, Humans, Solubility, Albendazole, Nanoparticles, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
