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Cited by 686Fatty Acid Research and HealthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study

Schaefer, Ernst J., Bongard, Vanina, Beiser, Alexa S., Lamon-Fava, Stefania, Robins, Sander J., Au, Rhoda, Tucker, Katherine L., Kyle, David J., Wilson, Peter W. F., Wolf, Philip A.·2006·Archives of Neurology
DOI 10.1001/archneur.63.11.1545
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Abstract

BACKGROUND: Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia. OBJECTIVE: To determine whether plasma phosphatidylcholine (PC) DHA content is associated with the risk of developing dementia. DESIGN, SETTING, AND PARTICIPANTS: A prospective follow-up study in 899 men and women who were free of dementia at baseline, had a median age of 76.0 years, and were followed up for a mean of 9.1 years for the development of all-cause dementia and Alzheimer disease. MAIN OUTCOME MEASURES: Plasma PC fatty acid levels were measured at baseline. Cox proportional regression analysis was used to assess relative risks of all-cause dementia and Alzheimer disease according to baseline plasma levels. RESULTS: Ninety-nine new cases of dementia (including 71 of Alzheimer disease) occurred during the follow-up. After adjustment for age, sex, apolipoprotein E epsilon4 allele, plasma homocysteine concentration, and education level, subjects in the upper quartile of baseline plasma PC DHA levels, compared with subjects in the lower 3 quartiles, had a relative risk of 0.53 of developing all-cause dementia (95% confidence interval, 0.29-0.97; P=.04) and 0.61 of developing Alzheimer disease (95% confidence interval, 0.31-1.18; P=.14). Subjects in the upper quartile of plasma PC DHA levels had a mean DHA intake of 0.18 g/d and a mean fish intake of 3.0 servings per week (P<.001) in a subset of 488 participants. We found no other significant associations. CONCLUSION: The top quartile of plasma PC DHA level was associated with a significant 47% reduction in the risk of developing all-cause dementia in the Framingham Heart Study.

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Crossref · 10.1001/archneur.63.11.1545

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Metadata

Authors
Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A.
Affiliations
Boston University (US)
Corresponding author
Schaefer, Ernst J.
ORCID
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
2006-11-01
Volume
63
Issue
11
Pages
1545
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.63.11.1545
OpenAlex
W2149944282
Cited by
686
References
28
Citations by year
2026: 16 · 2025: 18 · 2024: 38 · 2023: 15 · 2022: 21 · 2021: 46 · 2020: 26 · 2019: 25 · 2018: 34 · 2017: 36 · 2016: 34 · 2015: 32 · 2014: 45 · 2013: 35 · 2012: 42
FWCI
36.99
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
Funders
  • U.S. Department of Agriculture (53-3K06-5-10)
  • Pfizer
  • University of Connecticut
  • National Institutes of Health (n01hc25195-41-0-1, N01-HC 25195)
  • National Institute on Aging (N01-HC-25195, 5R01-AG-08122-14, R01AG008122)
  • National Heart, Lung, and Blood Institute (HV83-03, N01‐HC25195)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
docosahexaenoic acid, phosphatidylcholine, plasma fatty acids, dementia risk, Alzheimer's disease, omega-3 fatty acids, fish consumption, Framingham Heart Study, APOE ε4, homocysteine
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Docosahexaenoic Acids, Female, Follow-Up Studies, Humans, Male, Mental Status Schedule, Phosphatidylcholines, Prospective Studies, Risk, Incidence, Proportional Hazards Models

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