The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Mediterranean Diet, Alzheimer Disease, and Vascular Mediation
Open accessAbstract
OBJECTIVES: To examine the association between the Mediterranean diet (MeDi) and Alzheimer disease (AD) in a different AD population and to investigate possible mediation by vascular pathways. Design, Setting, Patients, and MAIN OUTCOME MEASURES: A case-control study nested within a community-based cohort in New York, NY. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD status (194 patients with AD vs 1790 nondemented subjects) in logistic regression models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index (calculated as weight in kilograms divided by height in meters squared). We investigated whether there was attenuation of the association between MeDi and AD when vascular variables (stroke, diabetes mellitus, hypertension, heart disease, lipid levels) were simultaneously introduced in the models (which would constitute evidence of mediation). RESULTS: Higher adherence to the MeDi was associated with lower risk for AD (odds ratio, 0.76; 95% confidence interval, 0.67-0.87; P<.001). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had an odds ratio of 0.47 (95% confidence interval, 0.29-0.76) and those at the highest tertile an odds ratio of 0.32 (95% confidence interval, 0.17-0.59) for AD (P for trend <.001). Introduction of the vascular variables in the model did not change the magnitude of the association. CONCLUSIONS: We note once more that higher adherence to the MeDi is associated with a reduced risk for AD. The association does not seem to be mediated by vascular comorbidity. This could be the result of either other biological mechanisms (oxidative or inflammatory) being implicated or measurement error of the vascular variables.
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Cites
Inflammation and Alzheimer’s disease
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Mediterranean diet and risk for Alzheimer's disease
Scarmeas, N., Stern, Y., Tang, M., Mayeux, R., & Luchsinger, J. A. (2006) · Annals of Neurology · doi:10.1002/ana.20854 · Cited by 1,103
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“At the same time, there is strong evidence relating the MeDi to lower risk of vascular risk factors such as dyslipidemia,(5,6) hypertension,(3,5-7) abnormal glucose metabolism,(3,6) and coronary heart disease.(6,8-10) Thus, vascular variables are likely to be in the causal pathway between MeDi and AD and should be con…”
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Cited by
Epidemiology of Alzheimer disease
Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675
Self-citationEpidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261
Aerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007
Physical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916
Self-citationMediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793
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Metadata
- Authors
- Scarmeas, N., Stern, Y., Mayeux, R., & Luchsinger, J. A.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-12-01
- Volume
- 63
- Issue
- 12
- Pages
- 1709
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2114509850
- Cited by
- 434
- References
- 19
- FWCI
- 16.78
- Type
- journal article
- Language
- en
- Open access
- green
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