The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Epstein-Barr Virus and Multiple Sclerosis: Evidence of Association From a Prospective Study With Long-term Follow-up
Abstract
OBJECTIVE: To determine whether serum titers of anti-Epstein-Barr virus (EBV) antibodies are elevated in blood specimens collected up to 30 years prior to onset of multiple sclerosis (MS). METHODS: Individuals with MS were identified among members of the Kaiser Permanente Northern California health plan who participated in the multiphasic examinations administered between 1965 and 1974. Stored serum samples were used to compare anti-EBV antibody titers in 42 individuals who developed MS with age-matched and sex-matched controls. RESULTS: The geometric mean titers of antibodies to the Epstein-Barr nuclear antigen (EBNA) complex and its component EBNA-1 were significantly higher in the MS cases when compared with matched controls. The relative risk of MS associated with a 4-fold increase in antibody titers was 2.1 (95% confidence interval, 1.1-3.8) for the EBNA complex and 1.8 (95% confidence interval, 1.1-2.9) for EBNA-1. Elevations of antibody titers to the EBNA complex and EBNA-1 among MS cases first occurred between 15 to 20 years before the onset of symptoms and persisted thereafter. CONCLUSION: The elevation of anti-EBV titers is probably an early event in the pathogenesis of MS and is unlikely to be the result of an aspecific immune dysregulation.
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Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
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Self-citationEpidemiologic evidence for multiple sclerosis as an infection
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No one is naive: the significance of heterologous T-cell immunity
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Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure
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Cited by
Bjornevik, K., Cortese, M., Healy, B. C., Kuhle, J., Mina, M. J., Leng, Y., Elledge, S. J., Niebuhr, D. W., Scher, A. I., Munger, K. L., et al. (2022) · Science · doi:10.1126/science.abj8222 · Cited by 2,049
Self-citationInfectious causes of multiple sclerosis
Giovannoni, G., Cutter, G. R., Lunemann, J., Martin, R., Münz, C., Sriram, S., Steiner, I., Hammerschlag, M. R., & Gaydos, C. A. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70577-4 · Cited by 295
Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
Bjornevik, K., Münz, C., Cohen, J. I., & Ascherio, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00775-5 · Cited by 246
Self-citationEpstein-Barr Virus and Multiple Sclerosis
Lünemann, J. D., & Münz, C. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0038-y · Cited by 36
Allanach, J. R., Fettig, N. M., Hardman, B. K., Rosen, A. R., Fan, V., Chung, C., Goldberg, E. J., Morse, Z. J., Shanina, I., Vorobeychik, G., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu5110 · Cited by 14
Metadata
- Authors
- DeLorenze, G. N., Munger, K. L., Lennette, E. T., Orentreich, N., Vogelman, J. H., & Ascherio, A.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-06-01
- Volume
- 63
- Issue
- 6
- Pages
- 839
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2145992817
- Cited by
- 257
- References
- 27
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Epstein-Barr Virus and Multiple Sclerosis: Evidence of Association From a Prospective Study With Long-term Follow-up. https://app.cochat.ai/papers/10.1001/archneur.63.6.noc50328
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- DeLorenze, G. N., Munger, K. L., Lennette, E. T., Orentreich, N., Vogelman, J. H., & Ascherio, A. (2006). Epstein-Barr Virus and Multiple Sclerosis: Evidence of Association From a Prospective Study With Long-term Follow-up. Archives of Neurology. https://doi.org/10.1001/archneur.63.6.noc50328
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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