Ultrastructural Mitochondrial Abnormalities in Patients With Sporadic Amyotrophic Lateral Sclerosis
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Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS.
“Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS [281–285].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [283]
Cites
Mitochondrial fission in apoptosis, neurodegeneration and aging
Bossy‐Wetzel, E., Barsoum, M. J., Godzik, A., Schwarzenbacher, R., & Lipton, S. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.015 · Cited by 428 · see citing works
Higgins, C. M. J., Jung, C., & Xu, Z. (2003) · BMC Neuroscience · doi:10.1186/1471-2202-4-16 · Cited by 262 · see citing works
Cytochrome c Oxidase subunit I microdeletion in a patient with motor neuron disease
Comi, G. P., Bordoni, A., Salani, S., Franceschina, L., Sciacco, M., Prelle, A. C., Fortunato, F., Zeviani, M., Napoli, L., Bresolin, N., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410430119 · Cited by 247 · see citing works
Self-citationCrugnola, V., Lamperti, C., Lucchini, V., Ronchi, D., Peverelli, L., Prelle, A. C., Sciacco, M., Bordoni, A., Fassone, E., Fortunato, F., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.128 · Cited by 147 · see citing works
Mitochondrial Dynamics in Disease
Chan, D. C. (2007) · New England Journal of Medicine · doi:10.1056/nejmp078040 · Cited by 94 · see citing works
MITOCHONDRIOPATHY MIMICKING AMYOTROPHIC LATERAL SCLEROSIS
Finsterer, J. (2003) · The Neurologist · doi:10.1097/01.nrl.0000038589.58012.a8 · Cited by 20 · see citing works
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Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
Li, X., Dong, L., Li, A., Yi, J., Brotto, M., & Zhou, J. (2022) · Biomolecules · doi:10.3390/biom12020333 · Cited by 33 · see citing works
- Authors
- Napoli, L.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Napoli, Laura
- ORCID
- Napoli, Laura
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2011-12-01
- Volume
- 68
- Issue
- 12
- Pages
- 1612
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2089322876
- Cited by
- 21
- References
- 6
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- amyotrophic lateral sclerosis, sporadic ALS, mitochondrial abnormalities, mitochondrial ultrastructure, motor neuron disease
- MeSH terms
- Amyotrophic Lateral Sclerosis, Humans, Microscopy, Electron, Mitochondria
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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