The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Late-Onset Bleb Leaks After Glaucoma Filtering Surgery
Abstract
OBJECTIVE: To determine the incidence of focal, late-onset, conjunctival bleb leaks after glaucoma filtering surgery. DESIGN: Prospective, cross-sectional analysis. SETTING: Tertiary care outpatient referral center. PATIENTS: Consecutive patients who underwent glaucoma filtering surgery prior to June 1996 presenting for evaluation from September 2,1996, through November 15,1996. Five hundred twenty-five eyes of 525 consecutive patients were enrolled in the study. INTERVENTION: Bleb height (elevated or flat), area (diffuse or localized), and wall thickness (thin, thick, or encapsulated) were classified. Each bleb was tested for focal leakage using a moistened fluorescein strip, cobalt blue illumination, and slit-lamp biomicroscopy. Diffuse transconjunctival aqueous flow did not qualify as a focal leak. MAIN OUTCOME MEASURE: Seidel-positive aqueous leakage. RESULTS: Bleb leakage occurred in 14 eyes following trabeculectomy (mitomycin C treatment, 10 eyes; 5-fluorouracil treatment, 3 eyes; no antifibrosis agent, 1 eye) and in 1 eye following combined cataract and glaucoma surgery with adjunctive mitomycin C therapy. Bleb leakage occurred more frequently in eyes that received mitomycin C (10 [3.7%] of 273 eyes) than 5-fluorouracil (3 [1.4%] of 213 eyes) or no antifibrosis agent (1 [2.6%] of 39 eyes), using Kaplan-Meier estimates (P=.008, log-rank test). Conjunctival blebs were significantly thinner after trabeculectomy with mitomycin C than with 5-fluorouracil (P=.001). Bleb wall thickness was greater following combined cataract and glaucoma surgery than following trabeculectomy alone (P=.008). Age (P=.84), sex (P=.68), race (P=.77), duration of mitomycin C exposure (P=.62), number of antiglaucoma medications (P=.16), and total 5-fluorouracil dose (P=.85) were not associated with late-onset leaks. CONCLUSIONS: The risk of late-onset focal bleb leakage increases following trabeculectomy with mitomycin C therapy. Late leakage after combined cataract and glaucoma surgery is infrequent.
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Cites
Five-year Follow-up of the Fluorouracil Filtering Surgery Study
THE FLUOROURACIL FILTERING SURGERY STUDY GROUP (1996) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)70431-3 · Cited by 526
Intraoperative Mitomycin versus Postoperative 5-Fluorouracil in High-risk Glaucoma Filtering Surgery
Skuta, G. L., Beeson, C. C., Higginbotham, E. J., Lichter, P. R., Musch, D. C., Bergstrom, T. J., Klein, T. B., & Falck, F. Y. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31951-7 · Cited by 477
Fluorouracil Filtering Surgery Study One-Year Follow-up
FOURMAN, S., FRANKS, W., & HITCHINGS, R. (1990) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)70706-8 · Cited by 225
Mitomycin C versus 5-Fluorouracil in High-risk Glaucoma Filtering Surgery
Katz, G. J., Higginbotham, E. J., Lichter, P. R., Skuta, G. L., Musch, D. C., Bergstrom, T. J., & Johnson, A. T. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30875-5 · Cited by 223
Excretion of Fluorescein Into Breast Milk
Mattern, J., & Mayer, P. R. (1990) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)70694-4 · Cited by 20
Cited by
Primary Open-Angle Glaucoma Preferred Practice Pattern®
Gedde, S. J., Vinod, K., Wright, M. M., Muir, K. W., Lind, J. T., Chen, P. P., Li, T., & Mansberger, S. L. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2020.10.022 · Cited by 474
Rulli, E., Biagioli, E., Riva, I., Gambirasio, G., De Simone, I., Floriani, I., & Quaranta, L. (2013) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.5059 · Cited by 265
Li, Z., Van Bergen, T., Van de Veire, S., Van de Vel, I., Moreau, H., Dewerchin, M., Maudgal, P. C., Zeyen, T., Spileers, W., Moons, L., et al. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2662 · Cited by 223
Metadata
- Authors
- Greenfield, D. S.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1998-04-01
- Volume
- 116
- Issue
- 4
- Pages
- 443
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1970526607
- Cited by
- 258
- References
- 5
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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