The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oxidative DNA Damage in the Human Trabecular Meshwork: Clinical Correlation in Patients With Primary Open-Angle Glaucoma
Abstract
OBJECTIVE: To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration. METHODS: DNA was extracted from human trabecular meshwork specimens collected from 17 glaucoma-affected patients using standard filtration surgery. Twenty-one specimens from healthy eyes collected for cornea transplants serve as controls. Oxidative DNA damage was evaluated by determining 8-hydroxy-2'-deoxyguanosine levels. All patients underwent a Humphrey 30-2 visual field examination and diurnal tonometry before surgery. RESULTS: The mean +/- SD DNA oxidative damage was 8.51 +/- 5.44 and 1.75 +/- 1.80 8-hydroxy-2'-deoxyguanosine molecules/10(5) normal nucleotides in patients with glaucoma and controls, respectively. A statistically significant correlation was found among human trabecular meshwork DNA oxidative damage, visual field damage, and intraocular pressure. No other statistically significant correlations were found. CONCLUSIONS: Oxidative stress may represent an important pathogenetic step in primary open-angle glaucoma because it could induce human trabecular meshwork degeneration, favoring an intraocular pressure increase, thus priming the glaucoma pathogenetic cascade.
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Cites
Reactive oxygen species: the unavoidable environmental insult?
Gracy, R. W., Talent, J. M., Kong, Y., & Conrad, C. C. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s1383-5742(99)00027-7 · Cited by 182 · cited 1×
“19 23 13 (11) 12 (6) 23 19 (23) 15 (19) 26”
Cited by
Changes in aqueous humor dynamics with age and glaucoma
Gabelt, B. T., & Kaufman, P. L. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.10.003 · Cited by 377
Mitochondrial Abnormalities in Patients with Primary Open-Angle Glaucoma
Abu-Amero, K. K., Morales, J., & Bosley, T. M. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1639 · Cited by 337
The Role of Inflammation in the Pathogenesis of Glaucoma
Vohra, R., Tsai, J. C., & Kolko, M. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.08.010 · Cited by 214
The Eye, Oxidative Damage and Polyunsaturated Fatty Acids
Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E. (2018) · Nutrients · doi:10.3390/nu10060668 · Cited by 150
Self-citationMohanty, K., Dada, R., & Dada, T. (2017) · Ophthalmic Genetics · doi:10.1080/13816810.2016.1261904 · Cited by 30
Metadata
- Authors
- Saccà, S. C.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2005-04-01
- Volume
- 123
- Issue
- 4
- Pages
- 458
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2088402556
- Cited by
- 377
- References
- 1
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saccà, S. C. (2005). Oxidative DNA Damage in the Human Trabecular Meshwork: Clinical Correlation in Patients With Primary Open-Angle Glaucoma. Archives of Ophthalmology. https://doi.org/10.1001/archopht.123.4.458
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